Results 31 to 40 of about 5,812 (161)
Acellular Pertussis Vaccine Components: Today and Tomorrow
Vaccines, 2020 Pertussis is a highly communicable acute respiratory infection caused by Bordetella pertussis. Immunity is not lifelong after natural infection or vaccination. Pertussis outbreaks occur cyclically worldwide and effective vaccination strategies are needed
Kalyan K. Dewan +3 more
doaj +1 more source
Characterization of the Filamentous Hemagglutinin-Like Protein FhaS in Bordetella bronchiseptica [PDF]
Infection and Immunity, 2005 ABSTRACT Filamentous hemagglutinin (FHA) is a large (>200 kDa), rod-shaped protein expressed by bordetellae that is both surface-associated and secreted. FHA mediates bacterial adherence to epithelial cells and macrophages in vitro and is absolutely required for tracheal colonization in vivo. The recently sequenced
Steven M, Julio, Peggy A, Cotter
openaire +2 more sources
Mutant of Bordetella pertussis which lacks ability to produce filamentous hemagglutinin [PDF]
Infection and Immunity, 1982 Mutant cultures that lacked the ability to produce filamentous hemagglutinin were obtained by UV irradiation of Bordetella pertussis strain 18-323. Various biological activities of these mutants were compared with those of the parent culture. It was found that the leukocytosis-promoting, histamine-sensitizing, and mouse-protecting activities of the ...
M, Watanabe, Y, Nakase
openaire +2 more sources
BMC Immunology, 2021 Background The necessity of the tetanus-reduced dose diphtheria-acellular pertussis (Tdap) vaccine in adolescence and adults has been emphasized since the resurgence of small-scale pertussis in Korea and worldwide due to the waning effect of the vaccine ...
Kyu Ri Kang +3 more
doaj +1 more source
Cloning of the filamentous hemagglutinin of Bordetella pertussis and its expression in Escherichia coli [PDF]
Infection and Immunity, 1987 Bordetella pertussis UT25 DNA was cloned into the kanamycin resistance gene of cosmid pCP13 to construct a genomic library in Escherichia coli LE392. One clone containing plasmid pDB441 expressed the filamentous hemagglutinin (FHA) as identified by protein immunoblots with the use of rabbit anti-B.
D R, Brown, C D, Parker
openaire +2 more sources
Computational and Structural Biotechnology Journal, 2022 The BvgAS two-component system regulates virulence gene expression in Bordetella pertussis. Although precise three-dimensional structural information is not available for the response regulator BvgA, its sequence conservation with E.
David Kim +12 more
doaj +1 more source
Identification of immunodominant epitopes in the filamentous hemagglutinin ofBordetella pertussis [PDF]
FEMS Immunology & Medical Microbiology, 1999 The filamentous hemagglutinin (FHA) of Bordetella pertussis is a principal adhesin, which plays a key role in the colonization of the upper respiratory tract. FHA is also a protective antigen, which has been incorporated in the new generation of acellular vaccines against whooping cough. The protein is synthesized as a large 367-kDa precursor, which is
openaire +3 more sources
Identification of a carbohydrate recognition domain in filamentous hemagglutinin from Bordetella pertussis [PDF]
Infection and Immunity, 1993 The adherence of Bordetella pertussis to ciliated cells and macrophages is critical to colonization and infection of the respiratory tract. Adherence to both types of cells involves the recognition of eukaryotic carbohydrates by the bacterial adhesin filamentous hemagglutinin (Fha).
S M, Prasad +4 more
openaire +2 more sources
Influenza A virus surface proteins are organized to help penetrate host mucus
eLife, 2019 Influenza A virus (IAV) enters cells by binding to sialic acid on the cell surface. To accomplish this while avoiding immobilization by sialic acid in host mucus, viruses rely on a balance between the receptor-binding protein hemagglutinin (HA) and the ...
Michael D Vahey, Daniel A Fletcher
doaj +1 more source
Proinflammatory and Proapoptotic Activities Associated withBordetella pertussisFilamentous Hemagglutinin [PDF]
Infection and Immunity, 2001 ABSTRACTFilamentous hemagglutinin (FHA) is a dominant cell surface-associatedBordetella pertussisadhesin. Recognition that this protein is secreted in significant amounts and that bacterial adhesins may have other actvities, prompted an assessment of FHA effects on human macrophages.
T, Abramson, H, Kedem, D A, Relman
openaire +2 more sources