Modulation of the host interferon response and ISGylation pathway by B. pertussis filamentous hemagglutinin. [PDF]
PLoS ONE, 2011 Bordetella pertussis filamentous hemagglutinin (FHA) is a surface-associated and secreted protein that serves as a crucial adherence factor, and displays immunomodulatory activity in human peripheral blood mononuclear cells (PBMCs).
Christine Dieterich, David A Relman
doaj +5 more sources
Bordetella filamentous hemagglutinin and fimbriae: critical adhesins with unrealized vaccine potential. [PDF]
Pathogens and Disease, 2015 Pertussis, or whooping cough, is a highly contagious respiratory disease that is caused by the Gram-negative bacterium Bordetella pertussis, which is transmitted exclusively from human to human. While vaccination against B. pertussis has been successful, replacement of the whole cell vaccine with an acellular component vaccine has correlated with ...
Peggy Cotter, Erich V Scheller
exaly +5 more sources
New Insight into Filamentous Hemagglutinin Secretion Reveals a Role for Full-Length FhaB in
mBio, 2015 Bordetella filamentous hemagglutinin (FHA), a primary component of acellular pertussis vaccines, contributes to virulence, but how it functions mechanistically is unclear. FHA is first synthesized as an ~370-kDa preproprotein called FhaB. Removal of an N-
Jeffrey A. Melvin +3 more
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Both CD4+ and CD8+ Lymphocytes Participate in the IFN-γ Response to Filamentous Hemagglutinin from Bordetella pertussis in Infants, Children, and Adults [PDF]
Clinical and Developmental Immunology, 2012 Infant CD4+ T-cell responses to bacterial infections or vaccines have been extensively studied, whereas studies on CD8+ T-cell responses focused mainly on viral and intracellular parasite infections.
Violette Dirix +6 more
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Use of the Chinchilla model to evaluate the vaccinogenic potential of the Moraxella catarrhalis filamentous hemagglutinin-like proteins MhaB1 and MhaB2. [PDF]
PLoS ONE, 2013 Moraxella catarrhalis causes significant health problems, including 15-20% of otitis media cases in children and ~10% of respiratory infections in adults with chronic obstructive pulmonary disease.
Teresa L Shaffer +4 more
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Bordetella pertussis and Bordetella bronchiseptica filamentous hemagglutinins are processed at different sites [PDF]
FEBS Open Bio, 2018 Filamentous hemagglutinin (FHA) mediates adherence and plays an important role in lower respiratory tract infections by pathogenic Bordetellae. The mature FHA proteins of B. pertussis (Bp‐FHA) and the B.
David Jurnecka +3 more
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Filamentous Hemagglutinin of Bordetella pertussis Does Not Interact with the β2 Integrin CD11b/CD18. [PDF]
Int J Mol Sci, 2022 The pertussis agent Bordetella pertussis produces a number of virulence factors, of which the filamentous hemagglutinin (FhaB) plays a role in B. pertussis adhesion to epithelial and phagocytic cells. Moreover, FhaB was recently found to play a crucial role in nasal cavity infection and B. pertussis transmission to new hosts.
Golshani M +7 more
europepmc +4 more sources
Screening and Genomic Characterization of Filamentous Hemagglutinin-Deficient Bordetella pertussis. [PDF]
Infect Immun, 2018 ABSTRACT Despite high vaccine coverage, pertussis cases in the United States have increased over the last decade. Growing evidence suggests that disease resurgence results, in part, from genetic divergence of circulating strain populations away from vaccine references. The United States employs acellular vaccines exclusively, and
Weigand MR +16 more
europepmc +4 more sources
<i>Bordetella</i> Filamentous Hemagglutinin, a Model for the Two-Partner Secretion Pathway. [PDF]
Microbiol Spectr, 2019 ABSTRACTBacteria use a variety of mechanisms to translocate proteins from the cytoplasm, where they are synthesized, to the cell surface or extracellular environment or directly into other cells, where they perform their ultimate functions. Type V secretion systems (T5SS) use β-barrel transporter domains to export passenger domains across the outer ...
Nash ZM, Cotter PA.
europepmc +4 more sources
Fha Deficient Bordetella pertussis Isolates in Iran with 50 Years Whole Cell Pertussis Vaccination
Iranian Journal of Public Health, 2021 Background: Bordetella pertussis, a highly contagious respiratory. Notably, the resurgence of pertussis has recently been associated with the lacking production of vaccine virulence factors.
Samaneh Saedi +5 more
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