Modulation of the NF-kappaB pathway by Bordetella pertussis filamentous hemagglutinin. [PDF]
PLoS ONE, 2008 Filamentous hemagglutinin (FHA) is a cell-associated and secreted adhesin produced by Bordetella pertussis with pro-apoptotic and pro-inflammatory activity in host cells.
Tzvia Abramson +2 more
doaj +6 more sources
Role of antibody to leukocytosis-promoting factor hemagglutinin and to filamentous hemagglutinin in immunity to pertussis [PDF]
Infection and Immunity, 1981 Gamma globulins were obtained from rabbits hyperimmunized with the filamentous hemagglutinin (FHA) or the leukocytosis-promoting factor hemagglutinin (LPF.HA) of Bordetella pertussis. Double immunodiffusion analyses showed the antibodies to be highly specific for the homologous antigen.
Y, Sato +4 more
openaire +4 more sources
New Insight into Filamentous Hemagglutinin Secretion Reveals a Role for Full-Length FhaB in
mBio, 2015 Bordetella filamentous hemagglutinin (FHA), a primary component of acellular pertussis vaccines, contributes to virulence, but how it functions mechanistically is unclear. FHA is first synthesized as an ~370-kDa preproprotein called FhaB. Removal of an N-
Jeffrey A. Melvin +3 more
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Modulation of the host interferon response and ISGylation pathway by B. pertussis filamentous hemagglutinin. [PDF]
PLoS ONE, 2011 Bordetella pertussis filamentous hemagglutinin (FHA) is a surface-associated and secreted protein that serves as a crucial adherence factor, and displays immunomodulatory activity in human peripheral blood mononuclear cells (PBMCs).
Christine Dieterich, David A Relman
doaj +2 more sources
Filamentous hemagglutinin of Bordetella pertussis: nucleotide sequence and crucial role in adherence. [PDF]
Proceedings of the National Academy of Sciences, 1989 Filamentous hemagglutinin is a surface-associated adherence protein of Bordetella pertussis, which is a component of some new acellular pertussis vaccines. The nucleotide sequence of an open reading frame that encompasses the filamentous hemagglutinin structural gene, fhaB, suggests that proteolytic processing is necessary to generate the mature 220 ...
D A, Relman +4 more
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Phage-Mediated Presentation of a Conserved HA2 Epitope From Influenza A Virus Elicits Significant IgY Antibody Responses in Broiler Chickens. [PDF]
Vet Med SciThe conserved region of HA2 peptide of Influenza A virus was expressed on the surface of Protein VIII from M13 phage. Immunization of broiler chickens by this hybrid phage showed high levels of antibody responses, highlighting its potential as a promising tool for universal vaccine development against Influenza A virus.
Lotfi Z, Golchin M, Shamshirgaran MA.
europepmc +2 more sources
Morphology-dependent entry kinetics and spread of influenza A virus [PDF]
The EMBO JournalInfluenza A viruses (IAV) display a broad variety of morphologies ranging from spherical to long filamentous virus particles. These diverse phenotypes are believed to allow the virus to overcome various immunological and pulmonary barriers during entry ...
Sarah Peterl +14 more
doaj +2 more sources
Both CD4+ and CD8+ Lymphocytes Participate in the IFN-γ Response to Filamentous Hemagglutinin from Bordetella pertussis in Infants, Children, and Adults [PDF]
Clinical and Developmental Immunology, 2012 Infant CD4+ T-cell responses to bacterial infections or vaccines have been extensively studied, whereas studies on CD8+ T-cell responses focused mainly on viral and intracellular parasite infections.
Violette Dirix +6 more
doaj +2 more sources
Filamentous Hemagglutinin of Bordetella pertussis [PDF]
Journal of Molecular Biology, 1994 A.M. Makhov +8 more
openaire +3 more sources
Use of the Chinchilla model to evaluate the vaccinogenic potential of the Moraxella catarrhalis filamentous hemagglutinin-like proteins MhaB1 and MhaB2. [PDF]
PLoS ONE, 2013 Moraxella catarrhalis causes significant health problems, including 15-20% of otitis media cases in children and ~10% of respiratory infections in adults with chronic obstructive pulmonary disease.
Teresa L Shaffer +4 more
doaj +2 more sources