Identification and regulation of expression of a gene encoding a filamentous hemagglutinin-related protein in
BMC Microbiology, 2007 Background Bordetella holmesii is a human pathogen closely related to B. pertussis, the etiological agent of whooping cough. It is able to cause disease in immunocompromised patients, but also whooping cough-like symptoms in otherwise healthy individuals.
Gross Roy +3 more
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<i>Bordetella</i> Filamentous Hemagglutinin, a Model for the Two-Partner Secretion Pathway. [PDF]
Microbiol Spectr, 2019 ABSTRACTBacteria use a variety of mechanisms to translocate proteins from the cytoplasm, where they are synthesized, to the cell surface or extracellular environment or directly into other cells, where they perform their ultimate functions. Type V secretion systems (T5SS) use β-barrel transporter domains to export passenger domains across the outer ...
Nash ZM, Cotter PA.
europepmc +4 more sources
Interaction of theBordetella pertussisfilamentous hemagglutinin with heparin [PDF]
FEMS Microbiology Letters, 1991 Heparin, a glycosaminoglycan synthesized in connective tissue-mast cells, appeared to inhibit the hemagglutination of rabbit erythrocytes induced by the filamentous hemagglutinin (FHA), a major adhesin of Bordetella pertussis. This inhibition suggested an interaction of heparin with the FHA region responsible for the hemagglutination activity.
F D, Menozzi, C, Gantiez, C, Locht
openaire +3 more sources
Fha Deficient Bordetella pertussis Isolates in Iran with 50 Years Whole Cell Pertussis Vaccination
Iranian Journal of Public Health, 2021 Background: Bordetella pertussis, a highly contagious respiratory. Notably, the resurgence of pertussis has recently been associated with the lacking production of vaccine virulence factors.
Samaneh Saedi +5 more
doaj +1 more source
Vaccines, 2021 Pertussis is an acute respiratory tract infection caused by Bordetella pertussis. Even though its current vaccine coverage is relatively broad, they still have some shortcomings such as short protection time and might be incapable of blocking the spread ...
Han Xu +10 more
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Role of antibody to leukocytosis-promoting factor hemagglutinin and to filamentous hemagglutinin in immunity to pertussis [PDF]
Infection and Immunity, 1981 Gamma globulins were obtained from rabbits hyperimmunized with the filamentous hemagglutinin (FHA) or the leukocytosis-promoting factor hemagglutinin (LPF.HA) of Bordetella pertussis. Double immunodiffusion analyses showed the antibodies to be highly specific for the homologous antigen.
Y, Sato +4 more
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Antigenic Analysis of Bordetella pertussis Filamentous Hemagglutinin with Phage Display Libraries and Rabbit Anti-Filamentous Hemagglutinin Polyclonal Antibodies [PDF]
Infection and Immunity, 1998 ABSTRACT Although substantial advancements have been made in the development of efficacious acellular vaccines against Bordetella pertussis , continued progress requires better understanding of the antigenic makeup of B.
D R, Wilson, A, Siebers, B B, Finlay
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Surface-associated filamentous hemagglutinin induces autoagglutination of Bordetella pertussis [PDF]
Infection and Immunity, 1994 Filamentous hemagglutinin (FHA) is a major adhesin produced by Bordetella pertussis, the etiologic agent of whooping cough. FHA has been shown to be surface associated but is also secreted by virulent bacteria. Microscopic observations of lungs of mice infected with B. pertussis showed that the bacteria grow as clusters within the alveolar lumen.
F D, Menozzi +4 more
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Haemophilus ducreyi Secretes a Filamentous Hemagglutinin-Like Protein [PDF]
Journal of Bacteriology, 1998 ABSTRACT We have identified two extremely large open reading frames (ORFs) in Haemophilus ducreyi 35000, lspA1 and lspA2 , each of which encodes a predicted protein product whose N-terminal half is approximately 43% similar to the N-terminal half of
C K, Ward +4 more
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Journal of Microbiology, Immunology and Infection, 2018 Background/Purpose: Although assessing the immunogenicity and protective efficacy of acellular pertussis (aP) vaccines via murine model studies faces limitations, preliminary assessments have been achieved by evaluating respiratory challenge and humoral ...
Dong Ho Huh +7 more
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