Genetically Diverse Filoviruses in Rousettus and Eonycteris spp. Bats, China, 2009 and 2015
Genetically divergent filoviruses detected in Rousettus and Eonycteris spp. bats in China exhibited 61%–99% nt identity with reported filoviruses, based on partial replicase sequences, and they demonstrated lung tropism.
Xing-Lou Yang +13 more
doaj +1 more source
Niemann-Pick C1 (NPC1)/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor [PDF]
We recently demonstrated that Niemann-Pick C1 (NPC1), a ubiquitous 13-pass cellular membrane protein involved in lysosomal cholesterol transport, is a critical entry receptor for filoviruses.
Chandran, Kartik +7 more
core +2 more sources
Increasing Occurrence of Marburg Virus Outbreaks in Africa: Risk Assessment for Public Health
Bat and Marburg virus (Filovirus). Left: A Rousettus aegyptiacus bat; Center: a distribution map of R. aegyptiacus; Right: EM of Marburg virus. (figure credits: Left Wikipedia Nilflughund Lithuanian Zoological Gardens, Center; Center: Wikipedia Nilflughund IUCN Red List of Threatened Species, right Wikipedia Marburg virus CDC Fred Murphy; J.
Harald Brüssow
wiley +1 more source
Ebola virus disease: past, present and future
Ebola virus disease is one of the most deadly ailments known to mankind due to its high mortality rate (up to 90%) accompanying with the disease. Ebola haemorrhagic fever (EHF) is an infectious disease of animal that can be transmitted to both human and ...
Harish Rajak +4 more
doaj +1 more source
Phosphatidylethanolamine: A key player in lung disease
Implication of PE in the aetiology of diverse diseases. The pivotal role of PE in driving lipid peroxidation during ferroptosis. Implications of PE metabolic dysregulation in pulmonary epithelial cells. Abstract Phosphatidylethanolamine (PE) is a pivotal glycerophospholipid that constitutes a significant portion of cellular membranes, playing a crucial
Linlin Zhang, Wanxin Duan, Liyang Li
wiley +1 more source
LLOVIU VIRUS - A NOVEL FILOVIRUS, ENDEMIC IN EUROPE
The data on a recently revealed novel filovirus (Lloviu virus, family Filoviridae, genera Cuevavirus) in Europe are viewed in this issue. The molecular-biological properties of genome fragments of Lloviu virus were isolated from perished bats ...
T. E. Sizikova +3 more
doaj +1 more source
The Antiviral Activity of Polyphenols
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard +5 more
wiley +1 more source
Exploring the Immunopathogenesis of Viral Hemorrhagic Fever in Mice with a Humanized Immune System
Viral hemorrhagic fever (VHF) as a disease entity was first codified in the 1930s by soviet scientists investigating patients suffering from hantavirus infection. The group of hemorrhagic fever viruses (HFVs) has since expanded to include members from at
Günther Schönrich, Martin J. Raftery
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Diverse hosts, diverse immune systems: Evolutionary variation in bat immunology
Bats are recognized to have distinct immune systems from other vertebrates that may allow them to host virulent pathogens without showing disease. However, these flying mammals are also incredibly diverse, such that bats should not be expected to be immunologically homogenous.
Daniel J. Becker +11 more
wiley +1 more source
PAirwise Sequence Comparison (PASC) and Its Application in the Classification of Filoviruses
PAirwise Sequence Comparison (PASC) is a tool that uses genome sequence similarity to help with virus classification. The PASC tool at NCBI uses two methods: local alignment based on BLAST and global alignment based on Needleman-Wunsch algorithm.
Tatiana Tatusova +2 more
doaj +1 more source

