Results 51 to 60 of about 4,558 (162)
Viral hemorrhagic fevers - a recurrent public health threat
Viral hemorrhagic fevers (VHFs) caused by viruses are severe infectious diseases that lead to serious disturbances of the body’s homeostasis, in most cases accompanied by symptoms of hemorrhagic diathesis.
Marcin Weiner, Karolina Tarasiuk
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Background and Aims Remdesivir (RDV), an inhibitor of coronavirus replication including SARS‐CoV‐2, has been approved for the treatment of COVID‐19. Nevertheless, its use during pregnancy lacks specific efficacy and safety data due to the exclusion of pregnant patients from clinical trials.
Diego F. Wyszynski +7 more
wiley +1 more source
PAirwise Sequence Comparison (PASC) and Its Application in the Classification of Filoviruses
PAirwise Sequence Comparison (PASC) is a tool that uses genome sequence similarity to help with virus classification. The PASC tool at NCBI uses two methods: local alignment based on BLAST and global alignment based on Needleman-Wunsch algorithm.
Tatiana Tatusova +2 more
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DrugBank database is mined to hunt prospective Ebola virus (EBOV) VP35 inhibitors utilizing docking calculations, molecular dynamics, molecular mechanics/generalized Born surface area binding energy calculations, and density functional theory computations.
Alaa H. M. Abdelrahman +5 more
wiley +1 more source
The Silent Risk of Sudan Virus: A Review Addressing Global Health Vulnerabilities
ABSTRACT Background and Aim Sudan Virus Disease (SVD) is a deadly hemorrhagic fever caused by the Sudan virus, first discovered in Sudan in 1976. This disease has been linked to several outbreaks in sub‐Saharan Africa, particularly in Uganda. The high fatality rate of SVD, ranging from 41% to 70%, emphasizes the critical need for effective preventive ...
Syed Masudur Rahman Dewan +1 more
wiley +1 more source
LLOVIU VIRUS - A NOVEL FILOVIRUS, ENDEMIC IN EUROPE
The data on a recently revealed novel filovirus (Lloviu virus, family Filoviridae, genera Cuevavirus) in Europe are viewed in this issue. The molecular-biological properties of genome fragments of Lloviu virus were isolated from perished bats ...
T. E. Sizikova +3 more
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Increasing Occurrence of Marburg Virus Outbreaks in Africa: Risk Assessment for Public Health
Bat and Marburg virus (Filovirus). Left: A Rousettus aegyptiacus bat; Center: a distribution map of R. aegyptiacus; Right: EM of Marburg virus. (figure credits: Left Wikipedia Nilflughund Lithuanian Zoological Gardens, Center; Center: Wikipedia Nilflughund IUCN Red List of Threatened Species, right Wikipedia Marburg virus CDC Fred Murphy; J.
Harald Brüssow
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Exploring the Immunopathogenesis of Viral Hemorrhagic Fever in Mice with a Humanized Immune System
Viral hemorrhagic fever (VHF) as a disease entity was first codified in the 1930s by soviet scientists investigating patients suffering from hantavirus infection. The group of hemorrhagic fever viruses (HFVs) has since expanded to include members from at
Günther Schönrich, Martin J. Raftery
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Remdesivir (GS-5734) Impedes Enterovirus Replication Through Viral RNA Synthesis Inhibition
Human enteroviruses are responsible for diverse diseases, from mild respiratory symptoms to fatal neurological complications. Currently, no registered antivirals have been approved for clinical therapy.
Wei Ye +16 more
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Phosphatidylethanolamine: A key player in lung disease
Implication of PE in the aetiology of diverse diseases. The pivotal role of PE in driving lipid peroxidation during ferroptosis. Implications of PE metabolic dysregulation in pulmonary epithelial cells. Abstract Phosphatidylethanolamine (PE) is a pivotal glycerophospholipid that constitutes a significant portion of cellular membranes, playing a crucial
Linlin Zhang, Wanxin Duan, Liyang Li
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