Approaches to demonstrating the effectiveness of filovirus vaccines: Lessons from Ebola and COVID-19
Frontiers in Immunology, 2023 Zaire ebolavirus (EBOV), Sudan ebolavirus (SUDV) and Marburg virus (MARV), are members of the Filoviridae family that can cause severe disease and death in humans and animals.
Marion F. Gruber +2 more
doaj +1 more source
Outbreak of Marburg hemorrhagic fever among miners in Kamwenge and Ibanda Districts, Uganda, 2007 [PDF]
, 2011 Marburg hemorrhagic fever was detected among 4 miners in Ibanda District, Uganda, from June through September, 2007. Infection was likely acquired through exposure to bats or bat secretions in a mine in Kamwenge District, Uganda, and possibly human-to ...
Atek Kagirita +31 more
core +2 more sources
High prevalence of IgG antibodies to Ebola virus in the Efé pygmy population in the Watsa region, Democratic Republic of the Congo [PDF]
, 2016 Background Factors related to the natural transmission of Ebola virus (EBOV) to humans are still not well defined. Results of previous sero-prevalence studies suggest that circulation of EBOV in human population is common in sub- Saharan Africa.
Afounde, Afongenda +8 more
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Potential Vaccines and Post-Exposure Treatments for Filovirus Infections
Viruses, 2012 Viruses of the family Filoviridae represent significant health risks as emerging infectious diseases as well as potentially engineered biothreats. While many research efforts have been published offering possibilities toward the mitigation of filoviral ...
Gene G. Olinger +6 more
doaj +1 more source
Current perspectives on the phylogeny of Filoviridae
Infection, Genetics and Evolution, 2011 (Uploaded by Plazi for the Bat Literature Project) Sporadic fatal outbreaks of disease in humans and non-human primates caused by Ebola or Marburg viruses have driven research into the characterization of these viruses with the hopes of identifying host tropisms and potential reservoirs.
Barrette, Roger W. +3 more
openaire +2 more sources
Cell Reports, 2023 Summary: Ebola virus (EBOV) and Bundibugyo virus (BDBV) belong to the family Filoviridae and cause a severe disease in humans. We previously isolated a large panel of monoclonal antibodies from B cells of human survivors from the 2007 Uganda BDBV ...
Rodrigo I. Santos +8 more
doaj +1 more source
Die IRE1-abhängige ER-Stress-Antwort wird durch antagonistische Effekte der Marburg Virus Proteine GP und VP30 ausbalanciert [PDF]
, 2019 Das Marburg Virus (MARV) gehört, wie das Ebola Virus (EBOV), zur Familie der Filoviridae. Im Menschen führt eine Infektion mit dem MARV häufig zu schweren Fiebererkrankungen mit einer Letalitätsrate von bis zu 90%.
Rohde, Cornelius
core +1 more source
Ebola virus: A global public health menace: A narrative review
Journal of Family Medicine and Primary Care, 2019 Ebola virus disease (EVD), a fatal viral hemorrhagic illness, is due to infection with the Ebola virus of the Filoviridae family. The disease has evolved as a global public health menace due to a large immigrant population.
Shamimul Hasan +3 more
doaj +1 more source
Lyophilisation of influenza, rabies and Marburg lentiviral pseudotype viruses for the development and distribution of a neutralisation-assay based diagnostic kit [PDF]
, 2014 Pseudotype viruses (PVs) are chimeric, replication-deficient virions that mimic wild-type virus entry mechanisms and can be safely employed in neutralisation assays, bypassing the need for high biosafety requirements and performing comparably to ...
Assar +44 more
core +3 more sources
ProTides for Antiviral Activity Beyond Liver Cells
Chemistry – A European Journal, EarlyView.A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel +5 more
wiley +1 more source