Results 111 to 120 of about 11,014 (267)

Possible leap ahead in filovirus therapeutics [PDF]

Cell Research, 2014
In a recent study published in Nature, Warren et al. describe the generation of a novel synthetic adenosine analogue, BCX4430, a synthetic drug-like small molecule that provides protection from Ebola and Marburg virus infection in animal models.
Darryl, Falzarano, Heinz, Feldmann
openaire   +2 more sources

Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections

Nature Communications, 2023
Marburg and Ebola filoviruses are two of the deadliest infectious agents and several outbreaks have occurred in the last decades. Although several receptors and co-receptors have been reported for Ebola virus, key host factors remain to be elucidated. In
Vanessa Monteil, Hyesoo Kwon, Lijo John, Cristiano Salata, Gustav Jonsson, Sabine U. Vorrink, Sofia Appelberg, Sonia Youhanna, Matheus Dyczynski, Alexandra Leopoldi, Nicole Leeb, Jennifer Volz, Astrid Hagelkruys, Max J. Kellner, Stéphanie Devignot, Georg Michlits, Michelle Foong-Sobis, Friedemann Weber, Volker M. Lauschke, Moritz Horn, Heinz Feldmann, Ulrich Elling, Josef M. Penninger, Ali Mirazimi   +23 more
doaj   +1 more source

Design and characterization of protective pan-ebolavirus and pan-filovirus bispecific antibodies

PLoS Pathogens
Monoclonal antibodies (mAbs) are an important class of antiviral therapeutics. MAbs are highly selective, well tolerated, and have long in vivo half-life as well as the capacity to induce immune-mediated virus clearance.
A. Wirchnianski, E. Nyakatura, A. Herbert, A. Kuehne, Shawn A. Abbasi, Catalina Florez, Nadia Storm, Lindsay G. A. McKay, Leandrew Dailey, Erin A. Kuang, Dafna M. Abelson, Anna Z. Wec, Srinjoy Chakraborti, Frederick W. Holtsberg, S. Shulenin, Z. Bornholdt, M. Aman, A. Honko, Anthony Griffiths, J. Dye, K. Chandran, Jonathan R. Lai   +21 more
semanticscholar   +1 more source

Climate Change‐Driven Heatwaves Pose Lethal Risks to Newborn Forest Bats

Ecology and Evolution, Volume 15, Issue 5, May 2025.
This is the first recorded case of forest bat mortality in temperate regions caused by heatwaves. The study suggests that forest fragmentation exposes bats to lethal thermal peaks, highlighting a previously overlooked impact of climate change on these mammals and potential interactions with forest fragmentation.
Danilo Russo, Anne Mäenurm, Luca Cistrone, Adriano Martinoli, Greta Foiani, Valentina Giongo, Stefania Leopardi   +6 more
wiley   +1 more source

Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies

mBio, 2016
The filovirus surface glycoprotein (GP) mediates viral entry into host cells. Following viral internalization into endosomes, GP is cleaved by host cysteine proteases to expose a receptor-binding site (RBS) that is otherwise hidden from immune ...
Zachary A. Bornholdt, Esther Ndungo, Marnie L. Fusco, Shridhar Bale, Andrew I. Flyak, James E. Crowe, Kartik Chandran, Erica Ollmann Saphire   +7 more
doaj   +1 more source

Process Intensification for Recombinant Marburg Virus Glycoprotein Production Using Drosophila S2 Cells

Engineering in Life Sciences, Volume 25, Issue 5, May 2025.
ABSTRACT Marburg marburgvirus (MARV) is a highly virulent human pathogen with limited therapeutic options. Recombinant MARV glycoprotein (GP) produced in Drosophila Schneider 2 (S2) cells has been extensively investigated as potential vaccine antigen with promising efficacy demonstrated in nonhuman primate models.
Sven Göbel, Ludwig Mayerlen, Isabelle Yazel Eiser, Lisa Fichtmueller, David Clements, Udo Reichl, Yvonne Genzel, AxelT. Lehrer   +7 more
wiley   +1 more source

Silver Nanoparticle‐Mediated Antiviral Efficacy against Enveloped Viruses: A Comprehensive Review

Global Challenges, Volume 9, Issue 5, May 2025.
Silver nanoparticles (AgNPs) exhibit broad‐spectrum antiviral activity by targeting key viral structures and processes. They disrupt viral envelopes, compromising integrity, and bind to nucleocapsids, impairing viral replication. AgNPs also inhibit glycoprotein interactions, preventing viral attachment and entry into host cells.
Ekaterine Mosidze, Gianluigi Franci, Federica Dell'Annunziata, Nicoletta Capuano, Marica Colella, Flora Salzano, Massimiliano Galdiero, Aliosha Bakuridze, Veronica Folliero   +8 more
wiley   +1 more source

Outbreak of Marburg hemorrhagic fever among miners in Kamwenge and Ibanda Districts, Uganda, 2007 [PDF]

, 2011
Marburg hemorrhagic fever was detected among 4 miners in Ibanda District, Uganda, from June through September, 2007. Infection was likely acquired through exposure to bats or bat secretions in a mine in Kamwenge District, Uganda, and possibly human-to ...
Atek Kagirita, Bausch, Bausch, Ben Jeffs, Brian Amman, Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, Craig Manning, Edgar Kansiime, Eileen C. Farnon, Emmanuel Byaruhanga, F. Katunguka, Florimond Tschioko, Godfrey S. Bwire, Jennifer Adjemian, Jentes, Jonathan Towner, Jordan W. Tappero, Joseph F. Wamala, Julius J. Lutwama, Pierre E. Rollin, Pierre Formenty, Robert Downing, Sam Ahimbisibwe, Stuart T. Nichol, Swanepoel, Taylor, Timen, Towner, Towner, Wahl-Jensen, World Health Organization   +31 more
core   +2 more sources

Application and comparison of lyophilisation protocols to enhance stable long-term storage of filovirus pseudotypes for use in antibody neutralisation tests [PDF]

, 2022
Martin Mayora Neto, Edward Wright, Nigel Temperton, Peter C. Soema, Rimko ten Have, Ivo Ploemen, Simon D. Scott   +6 more
openalex   +1 more source

Marburg Virus Disease: A Narrative Review

Health Science Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background and Aims Given the recent deadly outbreaks of the Marburg virus (MARV), in early 2023 in Tanzania and Equatorial Guinea, and the most recent one in Rwanda in 2024, there has been renewed attention across Africa on the threat posed by the re‐emergence of MARV as a growing concern for public health.
Arash Letafati, Somayeh Sadat Hosseini Fakhr, Ali Qaraee Najafabadi, Negin Karami, Hassan Karami   +4 more
wiley   +1 more source