Results 131 to 140 of about 5,390 (165)
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1993
Abstract The viral family known as the Filoviridae is unique among animal virus families: we understand virtually nothing about the natural history and maintenance strategies of any member of the family, yet Marburg and Ebola viruses are highly pathogenic for man and are capable of epidemic transmission (Table 15.1). Surely they are a
C J Peters +8 more
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Abstract The viral family known as the Filoviridae is unique among animal virus families: we understand virtually nothing about the natural history and maintenance strategies of any member of the family, yet Marburg and Ebola viruses are highly pathogenic for man and are capable of epidemic transmission (Table 15.1). Surely they are a
C J Peters +8 more
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Emerging and reemerging of filoviruses
1996Filoviruses are causative agents of a hemorrhagic fever in man with mortalities ranging from 22 to 88%. They are enveloped, nonsegmented negative-stranded RNA viruses and are separated into two types, Marburg and Ebola, which can be serologically, biochemically and genetically distinguished. In general, there is little genetic variability among viruses
H, Feldmann, W, Slenczka, H D, Klenk
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Reverse Genetics of Filoviruses
2017Reverse genetics systems are used for the generation of recombinant viruses. For filoviruses, this technology has been available for more than 15 years and has been used to investigate questions regarding the molecular biology, pathogenicity, and host adaptation determinants of these viruses.
Thomas, Hoenen +4 more
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2015
This chapter focuses on the viral hemorrhagic fever (VHF) viruses from two taxa, the families Arenaviridae and Filoviridae. The family Arenaviridae comprises 29 named viruses, which have unique morphologic and physiochemical characteristics. Antigenic relationships are established mainly on the basis of broadly reactive antibody binding assays ...
Pierre E. Rollin +3 more
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This chapter focuses on the viral hemorrhagic fever (VHF) viruses from two taxa, the families Arenaviridae and Filoviridae. The family Arenaviridae comprises 29 named viruses, which have unique morphologic and physiochemical characteristics. Antigenic relationships are established mainly on the basis of broadly reactive antibody binding assays ...
Pierre E. Rollin +3 more
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Rapid detection protocol for filoviruses
Journal of Clinical Virology, 2004The incidence of filovirus disease outbreaks has been increasing in recent years. Although there have been advances in the developments of diagnostics, field tests are rare. Apart from family members of infected patients, health care workers are at high risk of being infected during the initial phase of an outbreak.
Weidmann, Manfred +2 more
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Molecular biology and evolution of filoviruses
1993The family Filoviridae contains extremely pathogenic human viruses causing a fulminating, febrile hemorrhagic disease. Filoviruses are enveloped, filamentous particles with a nonsegmented negative-strand RNA genome showing the gene arrangement 3'-NP-VP35-VP40-GP-VP30-VP24-L-5'.
H, Feldmann, H D, Klenk, A, Sanchez
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Vaccine research efforts for filoviruses
International Journal for Parasitology, 2003Ebola and Marburg viruses belong to the family Filoviridae, and cause acute, frequently fatal, haemorrhagic fever in humans and non-human primates. No vaccines are available for human use. This review describes the status of research efforts to develop vaccines for these viruses and to identify the immune mechanisms of protection.
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Minigenome Systems for Filoviruses
2017Filoviruses are among the most pathogenic viruses known to man, and work with live viruses is restricted to maximum containment laboratories. In order to study individual aspects of the virus life cycle outside of maximum containment laboratories, life cycle modeling systems have been established, which use reporter-encoding miniature versions of the ...
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Fighting filoviruses with antibody therapy
Science, 2017Emerging Infections Ravn and Marburg viruses cause hemorrhagic fever with high morbidity rates in humans. Mire et al. tested the ability of previously identified human monoclonal antibodies to protect guinea pigs from lethal infection. One candidate antibody was administered 5 days after otherwise lethal Marburg or Ravn infection in nonhuman primates ...
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Inside the Cell: Assembly of Filoviruses
2017This chapter reviews our current knowledge about the spatiotemporal assembly of filoviral particles. We will follow particles from nucleocapsid entry into the cytoplasm until the nucleocapsids are enveloped at the plasma membrane. We will also highlight the currently open scientific questions surrounding filovirus assembly.
Larissa, Kolesnikova +3 more
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