Escherichia coli adhesion protein FimH exacerbates colitis via CD11b+CD103- dendritic cell activation [PDF]
Frontiers in Immunology, 2023 IntroductionImmune stimulators are used to improve vaccine efficiency; however, they are accompanied by various side effects. In previous studies, we reported that the Escherichia coli adhesion protein, FimH, induces immune activity; however, we did not ...
Wei Zhang +5 more
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Expression of E. coli FimH Enhances Trafficking of an Orally Delivered Lactobacillus acidophilus Vaccine to Immune Inductive Sites via Antigen-Presenting Cells [PDF]
Vaccines, 2023 The development of lactic acid bacteria as mucosal vaccine vectors requires the identification of robust mucosal adjuvants to increase vaccine effectiveness. The E.
Allison C. Vilander +3 more
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Computational and Structural Biotechnology Journal, 2022 The binding of the type 1 fimbrial adhesin FimH to mannosylated receptors is allosterically regulated to enhance the fitness of uropathogenic Escherichia coli (UPEC) during urinary tract infection (UTI).
Jilong Qin +5 more
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Structure-based design of an immunogenic, conformationally stabilized FimH antigen for a urinary tract infection vaccine. [PDF]
PLoS PathogensAdhesion of E. coli to the urinary tract epithelium is a critical step in establishing urinary tract infections. FimH is an adhesin positioned on the fimbrial tip which binds to mannosylated proteins on the urinary tract epithelium via its lectin domain (
Natalie C Silmon de Monerri +22 more
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Blockage of bacterial FimH prevents mucosal inflammation associated with Crohn’s disease [PDF]
Microbiome, 2021 Background An Escherichia coli (E. coli) pathotype with invasive properties, first reported by Darfeuille-Michaud and termed adherent-invasive E. coli (AIEC), was shown to be prevalent in up to half the individuals with Crohn’s Disease (CD), suggesting ...
Grégoire Chevalier +17 more
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En route to photoaffinity labeling of the bacterial lectin FimH [PDF]
Beilstein Journal of Organic Chemistry, 2010 Mannose-specific adhesion of Escherichia coli bacteria to cell surfaces, the cause of various infections, is mediated by a fimbrial lectin, called FimH.
Thisbe K. Lindhorst +3 more
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FimH adhesin of type 1 fimbriae is a potent inducer of innate antimicrobial responses which requires TLR4 and type 1 interferon signalling. [PDF]
PLoS Pathogens, 2008 Components of bacteria have been shown to induce innate antiviral immunity via Toll-like receptors (TLRs). We have recently shown that FimH, the adhesin portion of type 1 fimbria, can induce the innate immune system via TLR4.
Ali A Ashkar +4 more
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70274 TL1 team approach to investigating the adhesin gene fimH in adherent invasive E. coli induced inflammation and colorectal cancer development [PDF]
Journal of Clinical and Translational Science, 2021 IMPACT: We are developing the 3D perfusion system for use with patient-derived bacteria to further characterize the mechanism behind bacterial-induced inflammation and cancer. OBJECTIVES/GOALS: We previously reported the adherent invasive E.
Rachel C Newsome +8 more
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The Novel Type 1 Fimbriae FimH Receptor Calreticulin Plays a Role in Salmonella Host Specificity [PDF]
Frontiers in Cellular and Infection Microbiology, 2017 It was suggested that minor differences in the structure of FimH are most likely associated with differences in its adhesion specificities and may determine the tropism of various Salmonella serovars to different species and tissues.
Krzysztof Grzymajlo +7 more
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Journal of Microbiology, Immunology and Infection, 2022 Background: FimH adhesin is proposed to enhance Escherichia coli kidney infection by acting with PapGII adhesin, but genetic epidemiology study and animal study have not been widely conducted to confirm this hypothesis.
Chin-Chung Tseng +5 more
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