Results 11 to 20 of about 13,264 (267)

FimH and Anti-Adhesive Therapeutics: A Disarming Strategy Against Uropathogens [PDF]

Antibiotics, 2020
Chaperone-usher fimbrial adhesins are powerful weapons against the uropathogens that allow the establishment of urinary tract infections (UTIs). As the antibiotic therapeutic strategy has become less effective in the treatment of uropathogen-related UTIs,
Meysam Sarshar, Payam Behzadi, Cecilia Ambrosi, Carlo Zagaglia, Anna Teresa Palamara, Daniela Scribano   +5 more
doaj   +4 more sources

Monoclonal antibodies targeting the FimH adhesin protect against uropathogenic <i>E. coli</i> UTI. [PDF]

Sci Adv
As antimicrobial resistance increases, urinary tract infections (UTIs) are expected to pose an increased burden in morbidity and expense on the health care system, increasing the need for alternative antibiotic-sparing treatments. Most UTIs are caused by
Lopatto EDB, Santiago-Borges JM, Sanick DA, Malladi SK, Azimzadeh PN, Timm MW, Fox IF, Schmitz AJ, Turner JS, Sayed Ahmed SM, Ortinau L, Gualberto NC, Pinkner JS, Dodson KW, Ellebedy AH, Kau AL, Hultgren SJ.   +16 more
europepmc   +3 more sources

Escherichia coli adhesion portion FimH polarizes M2 macrophages to M1 macrophages in tumor microenvironment via toll-like receptor 4

Frontiers in Immunology, 2023
BackgroundMacrophages are key effector cells of innate immunity and play a critical role in the immune balance of disease pathogenesis, especially in the tumor microenvironment.
Wei Zhang, Li Xu, Xiaoyan Zhang, Jianqing Xu, Jun-O Jin, Jun-O Jin   +5 more
doaj   +2 more sources

FimH and Type 1 Pili Mediated Tumor Cell Cytotoxicity by Uropathogenic Escherichia coli In Vitro

Pathogens, 2023
Uropathogenic Escherichia coli express hairlike proteinaceous surface projections, known as chaperone–usher pathway (CUP) pili. Type 1 pili are CUP pili with well-established pathogenic properties. The FimH adhesin subunit of type 1 pili plays a key role
Shelly Roselyn Van Eyssen, Anastasia Samarkina, Ovgu Isbilen, Merve Suzan Zeden, Ender Volkan   +4 more
doaj   +2 more sources

Cranberry-Derived Phenolic Compounds Contribute to the Inhibition of FimH-Mediated <i>Escherichia coli</i> Hemagglutination. [PDF]

Antibiotics (Basel)
Background/Objectives: FimH adhesin, located at the tips of type 1 pili in Escherichia coli (E. coli), plays a crucial role in bacterial adhesion to the surface urothelial cells—a key step in the pathogenesis of urinary tract infections (UTIs). Given the
Ribić R, Petrović Peroković V, Meštrović T, Neuberg M, Bradić N.   +4 more
europepmc   +4 more sources

Insightful Improvement in the Design of Potent Uropathogenic E. coli FimH Antagonists

Pharmaceutics, 2023
Selective antiadhesion antagonists of Uropathogenic Escherichia coli (UPEC) type-1 Fimbrial adhesin (FimH) are attractive alternatives for antibiotic therapies and prophylaxes against acute or recurrent urinary tract infections (UTIs) caused by UPECs.
Leila Mousavifar, Meysam Sarshar, Clarisse Bridot, Daniela Scribano, Cecilia Ambrosi, Anna Teresa Palamara, Gérard Vergoten, Benoît Roubinet, Ludovic Landemarre, Julie Bouckaert, René Roy   +10 more
doaj   +2 more sources

Conformational ensembles in Klebsiella pneumoniae FimH impact uropathogenesis

Proceedings of the National Academy of Sciences
Significance Klebsiella pneumoniae is recognized by the CDC as a pathogen of urgent concern, due to the increase of multidrug-resistant strains. K. pneumoniae use type 1 pili tipped with the two-domain FimH adhesin to cause urinary tract infections (UTIs)
Edward D. B. Lopatto, J. Pinkner, Denise A Sanick, Robert F Potter, Lily X Liu, Jesús Bazán Villicaña, Kevin O. Tamadonfar, Yijun Ye, Maxwell I Zimmerman, Nathaniel C Gualberto, K. Dodson, J. Janetka, D. Hunstad, Scott J. Hultgren   +13 more
semanticscholar   +4 more sources

d-Mannose Treatment neither Affects Uropathogenic Escherichia coli Properties nor Induces Stable FimH Modifications

Molecules, 2020
Urinary tract infections (UTIs) are mainly caused by uropathogenic Escherichia coli (UPEC). Acute and recurrent UTIs are commonly treated with antibiotics, the efficacy of which is limited by the emergence of antibiotic resistant strains.
Daniela Scribano, Meysam Sarshar, Carla Prezioso, Marco Lucarelli, Antonio Angeloni, Carlo Zagaglia, Anna Teresa Palamara, Cecilia Ambrosi   +7 more
doaj   +2 more sources

Allelic functional variation of FimH among Salmonella enterica subspecies

Animal Diseases, 2023
Salmonella enterica has a wide diversity, with numerous serovars belonging to six different subspecies with dynamic animal-host tropism. The FimH protein is the adhesin mediating binding to various cells, and slight amino acid discrepancy significantly ...
Xiamei Kang, Jiaqi Chen, Xiao Zhou, Abdelaziz Ed-dra, Min Yue   +4 more
semanticscholar   +3 more sources

Binding site plasticity regulation of the FimH catch-bond mechanism

Biophysical Journal, 2022
The bacterial fimbrial adhesin FimH is a remarkable and well-studied catch-bond protein found at the tip of E. coli type 1 pili, which allows pathogenic strains involved in urinary tract infections to bind high-mannose glycans exposed on human epithelia.
Olivier Languin-Cattoën, Fabio Sterpone, Guillaume Stirnemann   +2 more
semanticscholar   +4 more sources