Results 21 to 30 of about 13,264 (267)

Mutation of Tyr137 of the universal Escherichia coli fimbrial adhesin FimH relaxes the tyrosine gate prior to mannose binding [PDF]

IUCrJ, 2017
The most prevalent diseases manifested by Escherichia coli are acute and recurrent bladder infections and chronic inflammatory bowel diseases such as Crohn's disease. E.
Said Rabbani, Eva-Maria Krammer, Goedele Roos, Adam Zalewski, Roland Preston, Sameh Eid, Pascal Zihlmann, Martine Prévost, Marc F. Lensink, Andrew Thompson, Beat Ernst, Julie Bouckaert   +11 more
doaj   +7 more sources

Orthogonal photoswitching of heterobivalent azobenzene glycoclusters: the effect of glycoligand orientation in bacterial adhesion [PDF]

Beilstein Journal of Organic Chemistry
Carbohydrate recognition is fundamental to a plethora of cellular processes and hence the elucidation of the structural determinants of the recognition process is a prerequisite for understanding and manipulating carbohydrate–protein interactions, such ...
Leon M. Friedrich, Thisbe K. Lindhorst
doaj   +2 more sources

Diazirine-functionalized mannosides for photoaffinity labeling: trouble with FimH [PDF]

Beilstein Journal of Organic Chemistry, 2018
Photoaffinity labeling is frequently employed for the investigation of ligand–receptor interactions in solution. We have employed an interdisciplinary methodology to achieve facile photolabeling of the lectin FimH, which is a bacterial protein, crucial ...
Femke Beiroth, Tomas Koudelka, Thorsten Overath, Stefan D. Knight, Andreas Tholey, Thisbe K. Lindhorst   +5 more
doaj   +4 more sources

Bacterial Lectin FimH and Its Aggregation Hot-Spots: An Alternative Strategy against Uropathogenic Escherichia coli

Pharmaceutics, 2023
Type I fimbriae are the main adhesive organelles of uropathogenic Escherichia coli (UPEC), consisting of four different subunits. Their component with the most important role in establishing bacterial infections is the FimH adhesin located at the ...
Georgia I. Nasi, Konstantina I. Georgakopoulou, Marilena K. Theodoropoulou, Nikos C. Papandreou, Evangelia D. Chrysina, Paraskevi L. Tsiolaki, Vassiliki A. Iconomidou   +6 more
doaj   +2 more sources

FimH-mannose noncovalent bonds survive minutes to hours under force.

Biophysical Journal
The adhesin FimH is expressed by commensal Escherichia coli and is implicated in urinary tract infections, where it mediates adhesion to mannosylated glycoproteins on urinary and intestinal epithelial cells in the presence of a high-shear fluid environment.
Laura A. Carlucci, Keith C. Johnson, W. Thomas   +2 more
semanticscholar   +3 more sources

Uropathogenic Escherichia coli niche occupancy determines the effects of mucosal vaccine against FimH [PDF]

Cell Reports
Summary: In people with urinary tract infections (UTIs), uropathogenic Escherichia coli (UPEC) often colonizes the gut, forming a reservoir and contributing to recurrent UTIs.
Jesús M. Santiago-Borges, Anne L. Rosen, Ariel Hernandez-Leyva, Christopher P. Tomera, Michael A. Lint, Alexandra E. Paharik, Vincent Vanyo, Jerome S. Pinkner, Karen W. Dodson, Swaine L. Chen, Chyi S. Hsieh, Scott J. Hultgren, Andrew L. Kau   +12 more
doaj   +2 more sources

Escherichia coli adhesion portion FimH functions as an adjuvant for cancer immunotherapy [PDF]

Nature Communications, 2020
Induction of antigen-specific immune activation by the maturation of dendritic cells (DCs) is a strategy used for cancer immunotherapy. In this study, we find that FimH, which is an Escherichia coli adhesion portion, induces toll-like receptor 4 ...
Wei Zhang, Li Xu, Hae‐Bin Park, Juyoung Hwang, Minseok Kwak, Peter Chang-Whan Lee, Guang Liang, Xiaoyan Zhang, Jianqing Xu, Jun‐O Jin   +9 more
openalex   +2 more sources

Determination of Effective Prophylactic Responses of Truncated Flagellin Protein as a Vaccine Candidate Against Uropathogenic <i>Escherichia coli</i>. [PDF]

Int J Microbiol
Uropathogenic Escherichia coli (UPEC) is a major cause of more than 80% of urinary tract infections (UTIs), a global health problem, and the second most common infectious disease. UTIs are responsible for approximately 40% of all nosocomial infections and 50% of all bacteremia.
Dehvari A, Bameri Z, Asadi Karam MR, Kord E, Oloomi M, Shahraki Zahedani S, Habibi M, Hashemzahi Z.   +7 more
europepmc   +2 more sources

Differential Expression of fimH, ihf, upaB, and upaH Genes in Biofilms‐ and Suspension‐Grown Bacteria From Samples of Different Uropathogenic Strains of Escherichia coli [PDF]

International Journal of Microbiology
Uropathogenic Escherichia coli (UPEC) strains are the main bacteria that cause urinary tract infections (UTIs). UPEC are a significant public health hazard due to their high proliferation, antibiotic resistance, and infection recurrence.
Esmeralda Rodríguez‐Miranda, María de Lourdes Reyes‐Escogido, Viridiana Olmedo-Ramírez, Octavio Jiménez-Garza, Sergio López-Briones, Marco Antonio Hernández-Luna   +5 more
openalex   +2 more sources

A Monitoring Method to Evaluate the Accumulation of Antimicrobial-Resistance Genes in Gram-Negative Bacteria Distributed in Environmental Water. [PDF]

Environ Microbiol Rep
There is less monitoring for antimicrobial‐resistance bacteria (AMRB) spread in the environment, probably due to costs. This study proposes a cost‐effective monitoring method based on isolating AMRB strains. This method enables us to understand the nature of environmental AMRB strains and assess their risk to humans and animals.
Yagi N, Miyazato S, Anh NQ, Huong BTM, Hirai I.   +4 more
europepmc   +2 more sources