Results 31 to 40 of about 13,264 (267)

Colistin and Biofilm-Related Genes of Positive Escherichia coli O157:H7 in Cattle (Bos taurus) Carcasses Antibiotic Resistance Profiles, Biofilm and Molecular Characterisation of Isolates. [PDF]

Vet Med Sci
Antimicrobial resistance in various infectious agents poses a public health threat. Therefore, this study aimed to determine the antibiotic resistance profiles, biofilm formation abilities and molecular characterisation of colistin‐resistant Escherichia coli O157:H7 from cattle carcasses.
Barel M, Koskeroglu K, Koca FD, Hizlisoy H, Disli HB, Dishan A, Satıcıoglu BI, Hizlisoy S.   +7 more
europepmc   +2 more sources

Cloning of fimH and fliC and expression of the fusion protein FimH/FliC from Uropathogenic Escherichia coli (UPEC) isolated in Iran

Iranian Journal of Microbiology, 2012
Background and Objectives: Urinary tract infection (UTI) is one of the most common infections in the world. The majority of UTIs are caused by Uropathogenic Escherichia coli (UPEC) strains.
Karam Mr Asadi, M Oloomi, M Habibi, S Bouzari   +3 more
doaj   +2 more sources

FimH family of type 1 fimbrial adhesins: functional heterogeneity due to minor sequence variations among fimH genes [PDF]

Journal of Bacteriology, 1994
We recently reported that the type 1-fimbriated Escherichia coli strains CSH-50 and HB101(pPKL4), both K-12 derivatives, have different patterns of adhesion to yeast mannan, human plasma fibronectin, and fibronectin derivatives, suggesting functional heterogeneity of type 1 fimbriae.
Evgeni V. Sokurenko, Harry S. Courtney, Dennis E. Ohman, Per Klemm, David L. Hasty   +4 more
openalex   +4 more sources

FimH as a scaffold for regulated molecular recognition [PDF]

Journal of Biological Engineering, 2021
AbstractBackgroundRecognition proteins are critical in many biotechnology applications and would be even more useful if their binding could be regulated. The current gold standard for recognition molecules, antibodies, lacks convenient regulation.
Shivani Gupta Ludwig, Casey L. Kiyohara, Laura A. Carlucci, Dagmara Kisiela, Evgeni V. Sokurenko, Wendy Evelyn Thomas   +5 more
openaire   +3 more sources

Safety and immunogenicity of an adjuvanted Escherichia coli adhesin vaccine in healthy women with and without histories of recurrent urinary tract infections: results from a first-in-human phase 1 study

Human Vaccines & Immunotherapeutics, 2021
Antibiotic resistance among gram-negative bacteria continues to rise globally at an alarming rate. New vaccines that prevent bacterial infections and reduce antibiotic use could provide a potential solution to these problems.
Gary R. Eldridge, Heidi Hughey, Lois Rosenberger, Steven M. Martin, Andrew Marc Shapiro, Elizabeth D’Antonio, Kent G. Krejci, Neal Shore, James Peterson, Andrea S. Lukes, Courtney M. Starks   +10 more
doaj   +1 more source

Detection of fimH virulence gene in uropathogenic Escherichia coli Using PCR [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2020
Urinary tract infections (UTIs) are one of main health problems caused by many microorganisms, including uropathogenic Escherichia coli (UPEC). The virulence factors are important in colonization of UPEC, extra-intestinal survival, and creation of ...
Rawan Amer Fadhil
doaj   +1 more source

Linker insertion analysis of the FimH adhesin of type 1 fimbriae in an Escherichia coli fimH-null background [PDF]

FEMS Microbiology Letters, 1996
The gene encoding the Escherichia coli FimH adhesin of type 1 fimbriae has been subjected to linker insertion mutagenesis. Amino acid changes were introduced at a number of positions spanning the entire sequence in order to probe the structure-function relationship of the FimH protein. The effect of these mutations on the ability of bacteria to express
Mark A. Schembri
  +6 more sources

Optimization and qualification of an assay that demonstrates that a FimH vaccine induces functional antibody responses in women with histories of urinary tract infections

Human Vaccines & Immunotherapeutics, 2021
Recurrent urinary tract infections (rUTI) are a serious disease associated with morbidities and mortality. Resistance to the standard of care antibiotics is now widespread because of the continued use of antibiotics among people who suffer from rUTI.
Courtney M. Starks, Michelle M. Miller, Peter M. Broglie, Joshua Cubbison, Steven M. Martin, Gary R. Eldridge   +5 more
doaj   +1 more source

A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis.

PLoS Pathogens, 2021
Type 1 pili have long been considered the major virulence factor enabling colonization of the urinary bladder by uropathogenic Escherichia coli (UPEC). The molecular pathogenesis of pyelonephritis is less well characterized, due to previous limitations ...
Lisa K McLellan, Michael R McAllaster, Arthur S Kim, Ľubomíra Tóthová, Patrick D Olson, Jerome S Pinkner, Allyssa L Daugherty, Teri N Hreha, James W Janetka, Daved H Fremont, Scott J Hultgren, Herbert W Virgin, David A Hunstad   +12 more
doaj   +1 more source

A cynomolgus monkey E. coli urinary tract infection model confirms efficacy of new FimH vaccine candidates

Infection and Immunity
The increase in urinary tract infections (UTI) caused by antibiotic-resistant Escherichia coli requires the development of new therapeutic agents and prophylactic vaccines.
Laurent Chorro, Tara Ciolino, Caresse Lynn Torres, Arthur Illenberger, JohnPaul Aglione, Paula Corts, Jacqueline Lypowy, Christopher Ponce, Annalena La Porte, Deborah A. Burt, Gretchen L. Volberg, Lila Ramaiah, Kathryn E. McGovern, Jian–Fang Hu, Annaliesa S. Anderson, Natalie C. Silmon de Monerri, Isis Kanevsky, Robert G. K. Donald   +17 more
openalex   +2 more sources