Results 41 to 50 of about 13,264 (267)

DETECTION FIMH AND PAPG GENES OF ESCHERICHIA COLI AND KLEBSIELLA PNEUMONIA ISOLATED FROM GALLSTONE , URINE STONE AND GASTROINTESTINAL CANAL BY POLYMERASE CHAIN REACTION (PCR) . [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2013
During this work twenty six isolates of Escherichia coli were collected (12 from gallstones , 10 from urin stones and 4 from gastrointestinal canal) and 14 isolates of Klebsiella pneumonia (4 from gallstones , 6 from urine stones and 4 from ...
MUTHANA BADEEA FARHAN, ALI SALIH HUSSAIN, AYAD MOHAMED ALI   +2 more
doaj   +1 more source

Pathogenic Potential of Invasive Mucosa-Associated Klebsiella pneumoniae Isolates in Ulcerative Colitis: Characterization of Virulence Factors and Inflammatory Response. [PDF]

Immun Inflamm Dis
This study was conducted in 83 patients with ulcerative colitis (UC). Klebsiella pneumoniae isolates showed a higher prevalence of virulence genes (fimH, hcp, fyuA, irp1) compared to non‐UC controls. UC isolates exhibited increased adhesion (29% vs. 8%) and invasion (16% vs.
Olamafar E, Yadegar A, Shahrokh S, Ebrahimi MT, Houri H.   +4 more
europepmc   +2 more sources

Positively selected FimH residues enhance virulence during urinary tract infection by altering FimH conformation [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance The evolution of multidrug resistance in pathogenic bacteria, including uropathogenic Escherichia coli (UPEC), that cause most urinary tract infections is becoming a worldwide crisis. UPEC use a variety of virulence factors and adhesins, including the mannose-binding FimH adhesin, to colonize ...
Drew J, Schwartz, Vasilios, Kalas, Jerome S, Pinkner, Swaine L, Chen, Caitlin N, Spaulding, Karen W, Dodson, Scott J, Hultgren   +6 more
openaire   +2 more sources

Probing the receptor recognition site of the FimH adhesin by fimbriae-displayed FimH---FocH hybrids [PDF]

Microbiology, 1998
Type 1 fimbriae are surface organelles of Escherichia coli which mediate D-mannose-sensitive binding to different host surfaces. This binding is conferred by the minor fimbrial component FimH. The binding domain of the FimH adhesin has been studied by constructing hybrids of FimH and a homologous protein, FocH, originating from F1C fimbriae.
Thomas B, Knudsen, Per, Klemm
openaire   +2 more sources

Evaluation of accessible regions of Escherichia coli fimH mRNA through computational prediction and experimental investigation

Iranian Journal of Microbiology, 2021
Background and Objectives: This study aimed to investigate the accessible regions of the fimH mRNA using computational prediction and dot-blot hybridization to increase the effectiveness of antisense anti-virulence therapeutics against Uropathogenic ...
Elnaz Harifi Mood, Alireza Japoni-Nejad, Mohammadreza Asadi Karam, Mohammad Pooya, Saeid Bouzari, Nader Shahrokhi   +5 more
doaj   +1 more source

FimH‐mediated autoaggregation of Escherichia coli [PDF]

Molecular Microbiology, 2001
Autoaggregation is a phenomenon thought to contribute to colonization of mammalian hosts by pathogenic bacteria. Type 1 fimbriae are surface organelles of Escherichia coli that mediate d‐mannose‐sensitive binding to various host surfaces. This binding is conferred by the minor fimbrial component FimH.
Schembri, M. A., Christiansen, G., Klemm, P.   +2 more
openaire   +4 more sources

Structure-Based Design of a Highly Immunogenic, Conformationally Stabilized FimH Antigen for a Urinary Tract Infection Vaccine [PDF]

bioRxiv
Adhesion of E. coli to the urinary tract epithelium is a critical step in establishing urinary tract infections. FimH is an adhesin positioned on the fimbrial tip which binds to mannosylated proteins on the urinary tract epithelium via its lectin domain (
Natalie C. Silmon de Monerri, Ye Che, Joshua A. Lees, J. Jasti, Huixian Wu, Matthew C. Griffor, Srinivas Kodali, Julio C. Hawkins, Jacqueline Lypowy, Christopher Ponce, Kieran Curley, Alexandre Esadze, Juan G. Cárcamo, David Keeney, Arthur Illenberger, Yury V. Matsuka, Suman Shanker, Laurent Chorro, Alexey V. Gribenko, Seungil Han, Annaliesa S. Anderson, Robert G. K. Donald   +21 more
openalex   +2 more sources

D-Mannoside FimH Inhibitors as Non-Antibiotic Alternatives for Uropathogenic Escherichia coli

Antibiotics, 2021
FimH is a type I fimbria of uropathogenic Escherichia coli (UPEC), recognized for its ability to adhere and infect epithelial urinary tissue. Due to its role in the virulence of UPEC, several therapeutic strategies have focused on the study of FimH ...
Alfredo Montes-Robledo, Rosa Baldiris-Avila, Johan Fabian Galindo   +2 more
doaj   +1 more source

Escherichia coli K1 RS218 Interacts with Human Brain Microvascular Endothelial Cells via Type 1 Fimbria Bacteria in the Fimbriated State [PDF]

, 2005
Escherichia coli K1 is a major gram-negative organism causing neonatal meningitis. E. coli K1 binding to and invasion of human brain microvascular endothelial cells (HBMEC) are a prerequisite for E.
Cai, M., di Cello, F., Khan, Naveed Ahmed, Kim, K.J., Kim, K.S., Shin, S., Teng, C.H., Xie, Y.   +7 more
core   +2 more sources

Recent Data Characterizing the Prevalence and Resistance Patterns of FimH-producing Uropathogenic Escherichia coli Isolated from Patients with Urinary Tract Infections in North Lebanon

Archives of Clinical Infectious Diseases, 2023
Background: The adhesin gene (FimH) of uropathogenic Escherichia coli (UPEC) plays a critical role in mediating the first contact of UPEC bacterial strains with uroepithelial cells, leading to colonization and invasion of host cells.
Sara Moubayed, Joyce Ghazzawi, Rosi Mitri, Sara Khalife   +3 more
semanticscholar   +1 more source