Results 51 to 60 of about 13,264 (267)

rbrothers: R Package for Bayesian Multiple Change-Point Recombination Detection. [PDF]

, 2013
Phylogenetic recombination detection is a fundamental task in bioinformatics and evolutionary biology. Most of the computational tools developed to attack this important problem are not integrated into the growing suite of R packages for statistical ...
Chattopadhyay, Sujay, Irvahn, Jan, Minin, Vladimir N, Sokurenko, Evgeni V   +3 more
core   +3 more sources

Allosteric Coupling in the Bacterial Adhesive Protein FimH [PDF]

Journal of Biological Chemistry, 2013
The protein FimH is expressed by the majority of commensal and uropathogenic strains of Escherichia coli on the tips of type 1 fimbriae and mediates adhesion via a catch bond to its ligand mannose. Crystal structures of FimH show an allosteric conformational change, but it remains unclear whether all of the observed structural differences are part of ...
Victoria B, Rodriguez, Brian A, Kidd, Gianluca, Interlandi, Veronika, Tchesnokova, Evgeni V, Sokurenko, Wendy E, Thomas   +5 more
openaire   +2 more sources

Beyond FimH: Diversity and Relevance of Carbohydrate-Binding Fimbrial Proteins in Escherichia coli. [PDF]

Chembiochem
This review discusses fimbrial lectins found in Escherichia coli (E. coli) other than FimH, which could be targeted to treat E. coli pathogenicity as an alternative to antibiotic treatment. Escherichia coli (E. coli) is responsible for multiple diseases in humans and animals.
Dulawa OR, Coyle SM, Walsh F, Velasco-Torrijos T.   +3 more
europepmc   +2 more sources

Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions [PDF]

, 2017
Positive selection in the two-domain type 1 pilus adhesin FimH enhances Escherichia coli fitness in urinary tract infection (UTI). We report a comprehensive atomic-level view of FimH in two-state conformational ensembles in solution, composed of one low ...
Dodson, Karen W, Gross, Michael L, Hannan, Thomas J, Hibbing, Michael E, Holehouse, Alex S, Hultgren, Scott J, Janetka, James, Kalas, Vasilios, Pappu, Rohit V, Pinkner, Jerome S, Tolia, Niraj H, Zhang, Hao   +11 more
core   +3 more sources

Nanobody mediated inhibition of attachment of F18 fimbriae expressing Escherichia coli [PDF]

, 2014
Post-weaning diarrhea and edema disease caused by F18 fimbriated E. coli are important diseases in newly weaned piglets and lead to severe production losses in farming industry.
Coddens, Annelies, Cox, Eric, De Greve, Henri, De Kerpel, Maia, Moonens, Kristof, Pardon, Els, Remaut, Han   +6 more
core   +4 more sources

The structure of the PapD-PapGII pilin complex reveals an open and flexible P5 pocket [PDF]

, 2012
P pili are hairlike polymeric structures that mediate binding of uropathogenic Escherichia coli to the surface of the kidney via the PapG adhesin at their tips.
Baga M, Bann JG, Barnhart MM, Dodson KW, Dodson KW, Doublie S, Gong M, Griebling TL, Henderson NS, Hess B, Holmgren A, Hooton TM, Hultgren SJ, Hung DL, Hung DL, Hung DL, Jacob-Dubuisson F, Jones CH, Justice SS, Kabsch W, Knight SD, Kuehn MJ, Kuehn MJ, Leslie A, Martinez JJ, Munera D, Nishiyama M, Painter J, Pellecchia M, Phan G, Remaut H, Remaut H, Roberts JA, Roberts JA, Rose RJ, Sauer FG, Sauer FG, Sauer FG, Saulino ET, Saulino ET, Sheldrick GM, Slonim LN, Striker R, Stromberg N, Verger D, Verger D, Volkan E, Wright KJ, Zavialov AV   +48 more
core   +2 more sources

Rate limiting step of the allosteric activation of the bacterial adhesin FimH investigated by molecular dynamics simulations

Proteins: Structure, Function, and Bioinformatics, 2023
The bacterial adhesin FimH is a model for the study of protein allostery because its structure has been resolved in multiple configurations, including the active and the inactive state.
G. Interlandi
semanticscholar   +1 more source

Catch-bond mechanism of the bacterial adhesin FimH [PDF]

Nature Communications, 2016
AbstractLigand–receptor interactions that are reinforced by mechanical stress, so-called catch-bonds, play a major role in cell–cell adhesion. They critically contribute to widespread urinary tract infections by pathogenic Escherichia coli strains. These pathogens attach to host epithelia via the adhesin FimH, a two-domain protein at the tip of type I ...
Sauer, Maximilian M., Jakob, Roman P., Eras, Jonathan, Baday, Sefer, Eris, Deniz, Navarra, Giulio, Bernèche, Simon, Ernst, Beat, Maier, Timm, Glockshuber, Rudi   +9 more
openaire   +6 more sources

Highly conserved type 1 pili promote enterotoxigenic E. coli pathogen-host interactions [PDF]

, 2017
Enterotoxigenic Escherichia coli (ETEC), defined by their elaboration of heat-labile (LT) and/or heat-stable (ST) enterotoxins, are a common cause of diarrheal illness in developing countries.
Begum, Yasmin Ara, Ciorba, Matthew A, Fleckenstein, James M, Hultgren, Scott J, Kuhlman, F. Matthew, Qadri, Firdausi, Rashu, Rasheduzzaman, Sheikh, Alaullah   +7 more
core   +3 more sources

Molecular Detection of Type 1 Fimbriae-Encoding Gene (fimH) in Uropathogenic Escherichia coli Strains Isolated from Outpatients with Urinary Tract Infection [PDF]

Journal of Advanced Biomedical Sciences, 2016
Background & Objective: Urinary Tract Infection (UTI) is one of the most common infections in all age groups. The majority of these infections are caused by Uropathogenic Escherichia coli (UPEC) strains. Colonization, attachment to uroepithelium, and the
Nemat Shams, Amin Jaydari
doaj   +2 more sources