Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice [PDF]
, 2012 Catheter-associated urinary tract infections (CAUTIs) constitute the majority of nosocomial urinary tract infections (UTIs) and pose significant clinical challenges.
Caparon, Michael G +8 more
core +2 more sources
Adaptations of Escherichia coli strains to oxidative stress are reflected in properties of their structural proteomes. [PDF]
, 2020 BACKGROUND:The reconstruction of metabolic networks and the three-dimensional coverage of protein structures have reached the genome-scale in the widely studied Escherichia coli K-12 MG1655 strain.
Catoiu, Edward +6 more
core +2 more sources
What contributes to an effective mannose recognition domain? [PDF]
, 2017 In general, carbohydrate-lectin interactions are characterized by high specificity but also low affinity. The main reason for the low affinities are desolvation costs, due to the numerous hydroxy groups present on the ligand, together with the typically ...
Eriş, Deniz +4 more
core +3 more sources
Monoclonal antibodies targeting the FimH adhesin protect against uropathogenic E. coli UTI
bioRxivAs antimicrobial resistance increases, urinary tract infections (UTIs) are expected to pose an increased burden in morbidity and expense on the healthcare system, increasing the need for alternative antibiotic-sparing treatments.
Edward D. B. Lopatto +16 more
semanticscholar +1 more source
bioRxiv, 2021 Bacterial interactions with surfaces rely on the coordinated expression and interplay of surface exposed adhesion factors. However, how bacteria dynamically modulate their vast repertoire of adhesins to achieve surface colonization is not yet well ...
Mari W. Yoshida +4 more
semanticscholar +1 more source
Molecular typing of uropathogenic isolated from Korean children with urinary tract infection [PDF]
Korean Journal of Pediatrics, 2015 PurposeWe investigated the molecular types of uropathogenic Escherichia coli (UPEC) by using conventional phylogrouping, multilocus sequence typing (MLST), and fimH genotyping.MethodsSamples of patients younger than 18 years of age were collected from ...
Ki Wook Yun +3 more
doaj +1 more source
Advanced Materials Interfaces, Volume 12, Issue 23, December 8, 2025.Given the growing interest in antibiotic‐free implant strategies and the need for biocompatible solutions to combat peri‐implantitis and implant failure, this review gives a timely and comprehensive overview of Ti‐Cu alloys as next‐generation biomaterials.
Brandon Fields +8 more
wiley +1 more source
Genotype detection of fimH gene of Acinetobacter baumannii isolated from different clinical cases
مجلة مركز بحوث التقنيات الاحيائية, 2019 Background: Forty isolates were obtained of Acinetobacter baumannii from (200) samples, the samples were collected from different cases including: - wounds, burns, Stool, Urinary tract infection urine. Aim of study: The aim of study is to isolate and
Rana M. Abdullah, Rasha Z. Ahmed
doaj +1 more source
Escherichia coli biofilms have an organized and complex extracellular matrix structure [PDF]
, 2013 Bacterial biofilms are ubiquitous in nature, and their resilience is derived in part from a complex extracellular matrix that can be tailored to meet environmental demands.
Chapman, Matthew R +9 more
core +2 more sources
FimH-based display of functional eukaryotic proteins on bacteria surfaces [PDF]
Scientific Reports, 2019 AbstractThe demand for recombinant proteins for analytic and therapeutic purposes is increasing; however, most currently used bacterial production systems accumulate the recombinant proteins in the intracellular space, which requires denaturating procedures for harvesting and functional testing. We here present a novel FimH-based expression system that
Markus Chmielewski +5 more
openaire +3 more sources