Results 41 to 50 of about 21,179 (270)
Molecular Imaging, 2007 Bioluminescence imaging (BLI) of luciferase reporters in small animal models offers an attractive approach to monitor regulation of gene expression, signal transduction, and protein-protein interactions, as well as following tumor progression, cell ...
Shimon Gross +4 more
doaj +1 more source
CBT‐Cys click reaction for optical bioimaging in vivo
View, 2023 Derived from the D‐luciferin regeneration pathway in firefly body, the click condensation reaction between 2‐cyanobenzothiazole (CBT) and D‐cysteine (Cys) (CBT‐Cys click reaction) possesses unique advantages, including superior biocompatibility, high ...
Xinyi Hu +5 more
doaj +1 more source
Red-Shifted Firefly Luciferase Optimized for Candida albicans In vivo Bioluminescence Imaging. [PDF]
, 2017 Candida albicans is a major fungal pathogen causing life-threatening diseases in immuno-compromised patients. The efficacy of current drugs to combat C. albicans infections is limited, as these infections have a 40-60% mortality rate.
Coste, A.T., Dorsaz, S., Sanglard, D.
core +2 more sources
CORE: Cholesterol Altered Lipid Nanoparticles for Splenic Expression of mRNA Payloads
Advanced Healthcare Materials, EarlyView.In this paper researchers introduce CORE LNPs, a new class of lipid nanoparticles engineered to redirect mRNA expression away from the liver and into the spleen, a key immune organ. By combining chemical design with computational tools, they created cholesterol analogs that enable precise spleen‐targeted expression, providing greater applications for ...
Eshan A. Narasipura +4 more
wiley +1 more source
Screening of the Pathogen Box for inhibitors with dual efficacy against Giardia lamblia and Cryptosporidium parvum. [PDF]
PLoS Neglected Tropical Diseases, 2018 There is need for a more efficient cell-based assay amenable to high-throughput drug screening against Giardia lamblia. Here, we report the development of a screening method utilizing G.
Kelly M Hennessey +10 more
doaj +1 more source
Method of detecting and counting bacteria in body fluids [PDF]
, 1973 A novel method is reported for determining bacterial levels in urine samples, which method depends on the quantitative determination of bacterial adenosine triphosphate (ATP) in the presence of non-bacterial ATP.
Chappelle, E. W., Picciolo, G. L.
core +1 more source
A Screenable In Vivo Assay for Mitochondrial Modulators Using Transgenic Bioluminescent Caenorhabditis elegans [PDF]
, 2015 Acknowledgements The authors would like to thank David Gray from the Dundee Drug discovery unit for kindly donating firefly luciferase inhibitory compounds DDD00001434, DDD0001477, DDD00000635 and DDD00023047; Tibor Harkani (Medical University of Vienna)
Glover, L Anne +2 more
core +1 more source
Advanced Materials, EarlyView.A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade +19 more
wiley +1 more source
Time Course of Bioluminescent Signal in Orthotopic and Heterotopic Brain Tumors in Nude Mice
BioTechniques, 2003 In vivo bioluminescence imaging is becoming increasingly popular. Quantification of bioluminescent signals requires knowledge of the variability and reproducibility of this technique.
J.S. Burgos +6 more
doaj +1 more source
A Computational Modeling of ADLumin Chemiluminescence: Oxygenation and Dioxetanone Formation. [PDF]
J Comput ChemChemiluminescent ADLumin molecules were studied using DFT to investigate their mechanisms of oxygenation and dioxetanone formation. Different oxygenation sites were explored for initiating competing reaction pathways that converge to the same 1,2‐dioxetanone intermediate.
Wickizer C +5 more
europepmc +2 more sources