Results 41 to 50 of about 14,327 (227)

Proposed biosynthetic pathway of firefly luciferin in the lantern of adult firefly.

open access: yes, 2013
Proposed biosynthetic pathway of firefly luciferin in the lantern of adult firefly.
Naoki Yoshida (504407)   +4 more
core   +1 more source

The transcriptome of the Bermuda fireworm Odontosyllis enopla (Annelida: Syllidae): A unique luciferase gene family and putative epitoky-related genes. [PDF]

open access: yesPLoS ONE, 2018
The Bermuda fireworm Odontosyllis enopla exhibits an extremely tight circalunar circadian behavior that results in an impressive bioluminescent mating swarm, thought to be due to a conventional luciferase-mediated oxidation of a light-emitting luciferin.
Mercer R Brugler   +3 more
doaj   +1 more source

Continuous Delivery of D-Luciferin by Implanted Micro-osmotic Pumps Enables True Real-Time Bioluminescence Imaging of Luciferase Activity in Vivo

open access: yesMolecular Imaging, 2007
Bioluminescence imaging (BLI) of luciferase reporters in small animal models offers an attractive approach to monitor regulation of gene expression, signal transduction, and protein-protein interactions, as well as following tumor progression, cell ...
Shimon Gross   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Mass spectrum of D-firefly luciferin by ESI-TOF-MS analysis.

open access: yes, 2013
A. The structure of D-firefly luciferin and the predicted mass fragment ions. The parent ion of D-luciferin at m/z 281 (M+H)+ (a), and its fragment ions at m/z 235 (b) and 177 (c). B. ESI-TOF-MS analysis of synthetic D-firefly luciferin.
Naoki Yoshida (504407)   +4 more
core   +1 more source

CBT‐Cys click reaction for optical bioimaging in vivo

open access: yesView, 2023
Derived from the D‐luciferin regeneration pathway in firefly body, the click condensation reaction between 2‐cyanobenzothiazole (CBT) and D‐cysteine (Cys) (CBT‐Cys click reaction) possesses unique advantages, including superior biocompatibility, high ...
Xinyi Hu   +5 more
doaj   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

open access: yesAdvanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang   +11 more
wiley   +1 more source

An allylated firefly luciferin analogue with luciferase specific response in living cells

open access: yes, 2018
An allylated firefly luciferin was successfully synthesized and its bioluminescence properties were evaluated.
Shigeru Nishiyama   +9 more
core   +1 more source

A Virus‐Inducible E3–RLCK–MADS Module Coordinates Suppression of Plant Immunity and Fertility in Rice

open access: yesAdvanced Science, EarlyView.
ABSTRACT Viruses often hijack host developmental programs to promote infection, but the mechanistic links between reproductive regulation and antiviral immunity remain incompletely understood. Here, we identify a virus‐triggered hierarchical degradation cascade that links antiviral immunity and fertility regulation in rice. We show that the rice grassy
Yuansheng Wu   +13 more
wiley   +1 more source

Time Course of Bioluminescent Signal in Orthotopic and Heterotopic Brain Tumors in Nude Mice

open access: yesBioTechniques, 2003
In vivo bioluminescence imaging is becoming increasingly popular. Quantification of bioluminescent signals requires knowledge of the variability and reproducibility of this technique.
J.S. Burgos   +6 more
doaj   +1 more source

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