Results 221 to 230 of about 1,699,088 (281)

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai   +12 more
wiley   +1 more source

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

open access: yesAdvanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang   +16 more
wiley   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

open access: yesAdvanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao   +20 more
wiley   +1 more source

Eating for performance: an evaluation of food consumption patterns and adherence to dietary guidelines in elite wheelchair basketball players. [PDF]

open access: yesPeerJ
Norte A   +11 more
europepmc   +1 more source

Evaluation of Biorefinery Products From <i>Microchloropsis gaditana</i>, <i>Isochrysis galbana</i>, and <i>Arthrospira platensis</i> in Juvenile Gilthead Seabream (<i>Sparus aurata</i>): Effect on Growth, Nutrient Utilization, Chemical Composition, Metabolism, and Intestinal Functionality. [PDF]

open access: yesAquac Nutr
Flores-Moreno S   +12 more
europepmc   +1 more source

Prebiotics and probiotics in animal nutrition: implications for food safety, sustainability, and circular production systems. [PDF]

open access: yesBraz J Microbiol
Dos Anjos Almeida JV   +4 more
europepmc   +1 more source

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