Results 41 to 50 of about 1,699,088 (281)

Evaluation of the Optimum Dietary Arachidonic Acid Level and Its Essentiality for Black Seabream (Acanthopagrus schlegelii): Based on Growth and Lipid Metabolism

Aquaculture Nutrition
The aim of this study was to investigate how dietary arachidonic acid (ARA) level affects growth performance and lipid metabolism in juvenile black seabream (Acanthopagrus schlegelii).
Yangguang Bao, Yuedong Shen, Wenli Zhao, Bingqian Yang, Xiaoyi Zhao, Shunshun Tao, Peng Sun, Óscar Monroig, Qicun Zhou, Min Jin   +9 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Vitamin D3 alleviates the damage caused by high-fat and maintains lipid metabolism homeostasis in hepatopancreas by promoting fatty acid β-oxidation of Portunus trituberculatus

Aquaculture Reports
The purpose of present study was to evaluate the effects of vitamin D3 supplementation in high-fat diet on growth performance, calcium and phosphorus in tissue, immunity and lipid metabolism, and to explore whether adding vitamin D3 to high-fat diet can ...
Haiqing Cao, Qijun Luo, Shichao Xie, Yuhui Cui, Wenhao Zhan, Yao Deng, Hongyu Peng, Zheng Tang, Yingqiu Tian, Min Jin, Peng Sun, Dongfa Zhu, Qicun Zhou   +12 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

A Phytobiotic Supersupplement From Murraya koenigii Improves Growth, Physiological Health, Skin Colour and Pattern in a Wild Ornamental Fish (Oreichthys crenuchoides) Under Captivity

Aquaculture Nutrition
Ornamental fish sector is one of the fastest growing industries in the world with an estimated market value of 18–20 billion USD. Despite its global economic significance, it suffers from several issues notably, high-cost carotenoids, inadequate seed ...
Nallaperumal Siva, Gouranga Biswas, Paramita Banerjee Sawant, Sujata Sahoo, Dilip Kumar Singh, Sweta Pradhan, Prem Kumar   +6 more
doaj   +1 more source

Vitamin D3 alleviates high-fat induced hepatopancreas lipid accumulation and inflammation by activating AMPKkα/PINK1/Parkin-mediated mitophagy in Litopenaeus vannamei

Aquaculture Reports, 2022
A high-fat diet (HFD) model was built to elucidate the regulatory mechanisms of vitamin D on lipid metabolism in shrimp. An 8-week feeding trial was aimed to determine whether dietary vitamin D3 would ameliorate the adverse effects of HFD feeding in ...
Tianmeng Dai, Jingjing Lu, Xinyue Tao, Xin Zhang, Ming Li, Min Jin, Peng Sun, Weijin Liu, Lefei Jiao, Qicun Zhou   +9 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Mycoprotein in enhancing growth and immunity of fish

Discover Food
Mycoprotein, a protein source derived from fungi, is being researched more and more in aquaculture for its ability to promote fish health, especially immunity, growth, and resistance to disease.
Nisha Chuphal, Mohd Ashraf Malik, Yash Khalasi, Patekar Prakash, T. Bhuvaneshwaran, Potluri Sai Kishore, Kedar Nath Mohanta   +6 more
doaj   +1 more source

Metabolic and nutritional effects of vitamin A on growth, lipid metabolism, antioxidant capacity and hepatopancreas health of juvenile mud crab (Scylla paramamosain)

Aquaculture Reports
An 8-week feeding trial was conducted to determine the effects of different vitamin A (VA) level on growth performance, lipid metabolism, antioxidant capacity and hepatopancreas health of juvenile mud crab (Scylla paramamosain).
Zheng Tang, Shichao Xie, Yao Deng, Wenhao Zhan, Hongyu Peng, Yinqiu Tian, Haiqing Cao, Min Jin, Binjie Zhou, Yushan Zou, Juntao Gu, Peng Sun, Qicun Zhou   +12 more
doaj   +1 more source