Results 101 to 110 of about 13,276,511 (306)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Ovsynch synchronization and fixed-time insemination in goats

Theriogenology, 2008
This study assessed the efficacy of an Ovsynch protocol (vs. the classical cronolone containing vaginal sponge+eCG treatment) to generate fixed-time insemination in goats during the breeding season. Each regimen was applied to 24 Boer goat does. Onset and duration of estrus were determined with an aproned male and follicular development was monitored ...
Hoitz, W., Sohnrey, Birgit, Gerland, M., Driancourt, M.-A.   +3 more
openaire   +3 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Cache-aware response time analysis for real-time tasks with fixed preemption points

, 2020
In real-time systems that employ preemptive scheduling and cache architecture, it is essential to account as precisely as possible for cache-related preemption delays in the schedulability analysis, as an imprecise estimation may falsely deem the system ...
Markovic, Filip,, Radu Dobrin, Carlson, Jan,, Filip Markovic, Jan Carlson, Dobrin, Radu,   +5 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Fixed-term employees in Australia: incidence and characteristics [PDF]

This paper presents an analysis of fixed-term employment in Australia or 3.3 per cent of employed persons in 2000. It finds that fixed-term employees are largely concentrated in Education (30 per cent of fixed- term employees in August 1998), Health and ...
Lou Will, Matthew Waite
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The isolation of nucleic acids from fixed, paraffin-embedded tissues-which methods are useful when?

, 2007
Museums and pathology collections around the world represent an archive of genetic material to study populations and diseases. For preservation purposes, a large portion of these collections has been fixed in formalin-containing solutions, a treatment ...
Haselkorn, Tamara, Michael Bunce, Gilbert, M.T.P., Worobey, Michael, Worobey Michael, Marck Eric Van, Lucas, S.B., Eric Van Marck, Haselkorn Tamara, Worobey, M., Sanchez, J., Lucas Sebastian B., Haselkorn, T., Van Marck, E., Sanchez, Juan J, Sebastian B Lucas, Lucas, Sebastian B., Sanchez Juan J., Juan J Sanchez, Laurence D Jewell, M Thomas P Gilbert, Sanchez, Juan J., Jewell, Laurence D., Tamara Haselkorn, Gilbert M. Thomas P., Gilbert, M. Thomas P., Jewell, L., Lucas, Sebastian B, Jewell, Laurence D, Van Marck, Eric, Jewell Laurence D., Gilbert, M Thomas P, Bunce, M., Michael Worobey, Bunce Michael, Bunce, Michael   +35 more
core   +1 more source