Results 101 to 110 of about 36,346 (215)

Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents

Nature Communications, 2019
Calcineurin is important for fungal virulence and a potential antifungal target, but compounds targeting calcineurin, such as FK506, are immunosuppressive. Here we report the crystal structures of calcineurin catalytic (CnA) and regulatory (CnB) subunits
Praveen R. Juvvadi, David Fox, Benjamin G. Bobay, Michael J. Hoy, Sophie M. C. Gobeil, Ronald A. Venters, Zanetta Chang, Jackie J. Lin, Anna Floyd Averette, D. Christopher Cole, Blake C. Barrington, Joshua D. Wheaton, Maria Ciofani, Michael Trzoss, Xiaoming Li, Soo Chan Lee, Ying-Lien Chen, Mitchell Mutz, Leonard D. Spicer, Maria A. Schumacher, Joseph Heitman, William J. Steinbach   +21 more
doaj   +1 more source

Tacrolimus (FK506) reduces ischemia-induced hippocampal damage in rats: a 7- and 30-day study

Brazilian Journal of Medical and Biological Research, 2003
The neuroprotective effect of the immunosuppressant agent FK506 was evaluated in rats after brain ischemia induced for 15 min in the 4-vessel occlusion model.
F. Giordani, A. Benetolli, L.A. Favero-Filho, K.C.M. Lima, L. Cestari Junior, H. Milani   +5 more
doaj   +1 more source

FK506 and protein kinase C [PDF]

Nature, 1991
M, Tropschug, R, Hofmann
openaire   +2 more sources

Effects of in vivo treatment with FK506 on natural killer cells in rats [PDF]

, 1991
Fung, JJ, Hiserodt, JC, Luchs, BA, Markus, PM, Starzl, TE, Van Den Brink, MRM   +5 more
core   +1 more source

Endogenous stem cell mobilization and localized immunosuppression synergistically ameliorate DSS-induced Colitis in mice

Stem Cell Research & Therapy
Background Stem cell therapy is a promising alternative for inflammatory diseases and tissue injury treatment. Exogenous delivery of mesenchymal stem cells is associated with instant blood-mediated inflammatory reactions, mechanical stress during ...
Shobha Regmi, Shiva Pathak, Dinesh Chaudhary, Jong Oh Kim, Joo-Won Nam, Hyung-Sik Kim, Hu-Lin Jiang, Dongryeol Ryu, Jong-Hyuk Sung, Simmyung Yook, Jee-Heon Jeong   +10 more
doaj   +1 more source

Combination of hydrotropic nicotinamide with nanoparticles for enhancing tacrolimus percutaneous delivery

International Journal of Nanomedicine, 2016
Wenhui Pan, Mengyao Qin, Guoguang Zhang, Yueming Long, Wenyi Ruan, Jingtong Pan, Zushuai Wu, Tao Wan, Chuanbin Wu, Yuehong Xu Department of Pharmaceutics, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, People’s Republic of ...
Pan W, Qin M, Zhang G, Long Y, Ruan W, Pan J, Wu Z, Wan T, Wu C, Xu Y   +9 more
doaj  

Immunosuppressant treatment reduces cocaine-induced behavioral sensitization in mice. [PDF]

Front Pharmacol
de Oliveira GL, Machado da Silva MC, Gomes GF, Ribeiro RDS, Cussat GR, Fernandes RA, Souza JLN, Fernandes HB, de Miranda AS, Santos VR, Bueno LL, Vieira LB, Moreira FA, de Oliveira ACP.   +13 more
europepmc   +1 more source

Posttransplant diabetes in pediatric recipients on Tacrolimus [PDF]

, 1999
Carlos Vivas, Carroll, Demetrius Ellis, Filler, Furth, John J. Fung, Mark L. Jordan, Miller, Moxey-Mimms, Ochiai, Pirsch, Richard L. Simmons, Ron Shapiro, Scantlebury, Shapiro, Shapiro, Shapiro, Susan Lombardozzi-Lane, Thomas E. Starzl, Uchida, Velma Scantlebury   +20 more
core   +1 more source

FK506 Binding Protein [PDF]

, 2020
openaire   +1 more source

Retraction Note: Neuroprotective effects of the Immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity. [PDF]

J Neuroinflammation
Fields JA, Overk C, Adame A, Florio J, Mante M, Pineda A, Desplats P, Rockenstein E, Achim C, Masliah E.   +9 more
europepmc   +1 more source