Results 31 to 40 of about 36,346 (215)

Immunosuppressive effect of PLGA-FK506-NPs in treatment of acute cardiac rejection via topical subcutaneous injection

Drug Delivery, 2021
FK506, a first-line immunosuppressant, is routinely administered orally and intravenously to inhibit activation and proliferation of T cells after heart transplantation (HT).
Cheng Deng, Qiaofeng Jin, Ya Wu, Huiling Li, Luyang Yi, Yihan Chen, Tang Gao, Wenyuan Wang, Jing Wang, Qing Lv, Yali Yang, Jia Xu, Wenpei Fu, Li Zhang, Mingxing Xie   +14 more
doaj   +1 more source

Role of FK506-sensitive signals in asthmatic lung inflammation

Frontiers in Immunology, 2022
Asthma is airway inflammatory diseases caused by the activation of group 2 innate lymphoid cells (ILC2s) and type 2 helper T (TH2) cells. Cysteine proteases allergen cause tissue damage to airway epithelial cells and activate ILC2-mediated type 2 airway ...
Chihiro Tomiaki, Kosuke Miyauchi, Sewon Ki, Yoshie Suzuki, Narumi Suzuki, Hiroshi Morimoto, Yohei Mukoyama, Masato Kubo, Masato Kubo   +8 more
doaj   +1 more source

FK506 Attenuated Pilocarpine-Induced Epilepsy by Reducing Inflammation in Rats

Frontiers in Neurology, 2019
Background: The status epilepticus (SE) is accompanied by a local inflammatory response and many oxygen free radicals. FK506 is an effective immunosuppressive agent with neuroprotective and neurotrophic effects, however, whether it can inhibit the ...
Aihua Wang, Aihua Wang, Zhihua Si, Zhihua Si, Xiaolin Li, Xiaolin Li, Lu Lu, Lu Lu, Yongli Pan, Yongli Pan, Jinzhi Liu, Jinzhi Liu   +11 more
doaj   +1 more source

Weaning of immunosuppression in long - Term liver transplant recipients [PDF]

, 1995
Seventy-two long-surviving liver transplant recipients were evaluated prospectively, including a baseline allograft biopsy for weaning off of immunosuppression.
Abu-Elmagd, K, Demetris, AJ, Ebert, F, Flynn, B, Fung, JJ, McMichael, J, Ramos, H, Reinsmoen, N, Reyes, J, Starzl, TE, Tzakis, A, Zeevi, A   +11 more
core   +1 more source

FK506 Nephrotoxicity

Renal Failure, 1999
Tacolimus (FK506) is a potent immunosuppressive agent with significant nephrotoxic properties. FK506 is complexed with an intracellular binding protein FKBP-12. Both the immunosuppressive and nephrotoxic effects may be linked to the inhibitory effect of this complex on calcineurin.
openaire   +2 more sources

Tacrolimus (FK506) prevents early stages of ethanol induced hepatic fibrosis by targeting LARP6 dependent mechanism of collagen synthesis.

PLoS ONE, 2013
Tacrolimus (FK506) is a widely used immunosuppressive drug. Its effects on hepatic fibrosis have been controversial and attributed to immunosuppression.
Zarko Manojlovic, John Blackmon, Branko Stefanovic   +2 more
doaj   +1 more source

Frequency-modulated nuclear localization bursts coordinate gene regulation [PDF]

, 2008
In yeast, the transcription factor Crz1 is dephosphorylated and translocates into the nucleus in response to extracellular calcium. Here we show, using time-lapse microscopy, that Crz1 exhibits short bursts of nuclear localization (typically lasting 2 ...
Cai, Long, Dalal, Chiraj K., Elowitz, Michael B.   +2 more
core   +2 more sources

Effect of Kaempferol on Tacrolimus-Induced Nephrotoxicity and Calcineurin B1 Expression Level in Animal Model

Journal of Experimental Pharmacology, 2020
Ahmed Shaker Ali,1,2 Abdullah Saddah Almalki,1,3 Basma Tarek Alharthy1 1Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt;
Ali AS, Almalki AS, Alharthy BT
doaj  

Treatment With Calcineurin Inhibitor FK506 Attenuates Noise-Induced Hearing Loss

Frontiers in Cell and Developmental Biology, 2021
Attenuation of noise-induced hair cell loss and noise-induced hearing loss (NIHL) by treatment with FK506 (tacrolimus), a calcineurin (CaN/PP2B) inhibitor used clinically as an immunosuppressant, has been previously reported, but the downstream ...
Zu-Hong He, Song Pan, Hong-Wei Zheng, Qiao-Jun Fang, Kayla Hill, Su-Hua Sha   +5 more
doaj   +1 more source

Tacrolimus in pediatric renal transplantation [PDF]

, 1996
Tacrolimus was used as the primary immunosuppressive agent in 69 pediatric renal transplantations between December 17, 1989, and June 30, 1995. Children undergoing concomitant or prior liver and/or intestinal transplantation were excluded from analysis ...
Ellis, D, Fung, JJ, Gilboa, N, Gritsch, HA, Hakala, TR, Irish, W, Jordan, ML, Lombardozzi-Lane, S, Scantlebury, VP, Shapiro, R, Simmons, RL, Starzl, TE, Vivas, C   +12 more
core   +1 more source