Results 51 to 60 of about 36,346 (215)

Discovery and validation of a urinary extracellular vesicle protein signature for the diagnosis of renal allograft fibrosis

Interdisciplinary Medicine, EarlyView.
Discovery and validation of a urinary extracellular vesicle protein signature for the diagnosis of renal allograft fibrosis. Abstract Interstitial fibrosis is the best indicator of irreversible or ongoing renal injury after kidney transplantation and faces considerable diagnostic challenges.
Wenxuan Zhao, Yang Xu, Yuewen Wang, Shihao Jin, Wenhui Wang, Zeming Yu, Yanwen Zhang, Yuxin Zhang, Deling Kong, Bing Wang, Zhenzhou Wu, Jie Zhao, Yuebing Wang   +12 more
wiley   +1 more source

Protective effect of Korean Red Ginseng against FK506-induced damage in LLC-PK1 cells

Journal of Ginseng Research, 2017
Background: Compound FK506 is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and inflammatory response mediated by FK506 limit its usefulness.
Dahae Lee, Ki Sung Kang, Jae Sik Yu, Jung-Yoon Woo, Gwi Seo Hwang, Dae-Woon Eom, Seung-Hoon Baek, Hye Lim Lee, Ki Hyun Kim, Noriko Yamabe   +9 more
doaj   +1 more source

Protective effect of FK506 combined with hypothermic mechanical perfusion on donor liver of rats [PDF]

Jichu yixue yu linchuang, 2021
Objective To investigate the protective effects of FK506 combined with low temperature mechanical perfusion on the reduction of ischemia reperfusion injury of rat liver transplants. Methods SD rats were divided into HTK group and FK506 + HTK group.
JIANG Li, LI Jian-hui, YU Hao, LI Hao-yu, XIE Hai-yang, ZHOU Lin, ZHENG Shu-sen
doaj  

Cutaneous Squamous Cell Carcinoma Amongst Solid Organ Transplant Recipients: A Systematic Review of Molecular Alterations

JEADV Clinical Practice, EarlyView.
ABSTRACT Background As solid organ transplantation becomes more prevalent, more patients are living on long‐term immunosuppression, greatly increasing the risk of cutaneous squamous cell carcinoma (cSCC). Although significant improvements have been achieved in the treatment of cSCC, further studies are needed to identify the specific protein expression
William Murray, Robin Caird, Michael O'Connor, Ciara Drumm, Emma O'Hora, Franklin Crossen, Aoife Lally, Aurelie Fabre, Roisin Dolan   +8 more
wiley   +1 more source

Solution structure of FK506 binding domain (FKBD) of Plasmodium falciparum FK506 binding protein 35 (PfFKBP35) [PDF]

Proteins: Structure, Function, and Bioinformatics, 2007
Plasmodium falciparum is the most lethal pathogen among four species of Plasmodium that infect human beings.1 The immunosuppressive drug FK506 shows an antimalarial effect,2 suggesting that the parasite may contain a potential FK506 binding protein (FKBP) as the molecular target of the drug.
Kang, Cong Bao, Ye, Hong, Yoon, Hye Rim, Yoon, Ho Sup   +3 more
openaire   +3 more sources

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

The role of acquired host immunity in periodontal diseases

Periodontology 2000, EarlyView.
Abstract The aim of this narrative review is to relate the contribution of European researchers to the complex topic of the host immune system in periodontal disease, focusing on acquired immunity. Other chapters in this volume will address the genetics and autoantibody responses and other forms of immunity to periodontal disease.
Denis F. Kinane, David F. Lappin, Shauna Culshaw   +2 more
wiley   +1 more source

Humoral and cellular immunopathology of hepatic and cardiac hamster-into-rat xenograft rejection: Marked stimulation of IgM^++bright/IgD^+dull splenic B cells [PDF]

, 1993
Normal Lewis rat serum contains antibodies (IgM > IgG) that bind to hamster leukocytes and endothelial cells. Transplantation of either the heart or liver from hamster rat results in release of hamster hematolymphoid cells from the graft, which lodge in ...
Celli, S, Demetris, AJ, Fung, JJ, Langer, A, Murase, N, Starzl, TE, Valdivia, LA, Woo, J   +7 more
core  

"Suboptimal" kidney donors: The experience with tacrolimus-based immunosuppression [PDF]

, 1996
Female, pediatric, and older donors have been associated with inferior graft survival after renal transplantation. We analyzed these three subgroups in 397 patients receiving tacrolimus-based immunosuppression. There were no differences in recipient age,
Alexander, Brenner, Brenner, Darras, Demetris, Gjertson, Gruessner, Hong, Laskow, McCauley, Neugarten, Nghiem, Opelz, Ploeg, Randhawa, Shapiro, Shapiro, Shapiro, Shapiro, Smith, Starzl, Starzl, Thorogood, Vivas   +23 more
core   +1 more source

Effects of FK506-binding Protein 12 and FK506 on Autophosphorylation of Epidermal Growth Factor Receptor [PDF]

Journal of Biological Chemistry, 1998
FK506-binding proteins and cyclophilins are intracellular proteins that express peptidylproline cis-trans-isomerase (PPIase) activity. The effects of FK506-binding protein 12 (FKBP12) and the cyclophilins 18 and 23 on autophosphorylation of the epidermal growth factor (EGF) receptor prepared from plasma membranes of the human epidermoid cell line A431 ...
M, Lopez-Ilasaca, C, Schiene, G, Küllertz, T, Tradler, G, Fischer, R, Wetzker   +5 more
openaire   +2 more sources