Results 81 to 90 of about 36,346 (215)

FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake

Molecular Medicine, 2020
Background Therapeutic lymphangiogenesis in an orthotopic lung transplant model has been shown to improve acute allograft rejection that is mediated at least in part through hyaluronan drainage.
Shikshya Shrestha, Woohyun Cho, Benjamin Stump, Jewel Imani, Anthony M. Lamattina, Pierce H. Louis, James Pazzanese, Ivan O. Rosas, Gary Visner, Mark A. Perrella, Souheil El-Chemaly   +10 more
doaj   +1 more source

Pregnancy after liver transplantation under tacrolimus [PDF]

, 1997
Background. The maternal and fetal risk of pregnancy after organ transplantation under tacrolimus has not been reported. This was prospectively studied in 27 pregnancies by 21 female liver recipients who were treated with tacrolimus before and throughout
Armenti, Ashok Jain, Bourget, Bourget, Bumgardner, Davison, Fung, Grenier, Guignard, Hamill, J. Carlton Gartner, Jackie Lever, Jain, John J. Fung, Klintmalm, Laifer, Lubchenco, McCauley, Metha, Penn, Radomski, Radomski, Raman Venkataramanan, Satlin, Scantlebury, Shaheen, Starzl, Starzl, The, The European, Thomas E. Starzl, Todo, Venkataramanan, Vijay Warty, Vijayan Balan, Warty, Winkler   +36 more
core   +1 more source

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, Volume 13, Issue 18, 27 March 2026.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

Therapeutic Effects of FK506 on IgA Nephropathy Rat

Kidney & Blood Pressure Research, 2017
Background/Aims: FK506 is an immunosuppressive drug and a calcineurin inhibitor that has been widely used in kidney disease in recent years. FK506 shows a wide range of biological and pharmaceutical effects; however, the mechanism of its anti ...
Linting Wei, Yan Du, Lining Jia, Xiaotao Ma, Zhao Chen, Jiamei Lu, Lifang Tian, Zhaoyang Duan, Fengming Dong, Zhian Lv, Ganglian Yao, Rongguo Fu, Li Wang   +12 more
doaj   +1 more source

Cyclophilin-A is bound to through its peptidylprolyl isomerase domain to the cytoplasmic dynein motor protein complex [PDF]

, 2004
Although cyclophilin A (CyP-A) is a relatively abundant small immunophilin present in the cytoplasm of all mammalian cells, its general function(s) in the absence of the immunosuppressant drug cyclosporin A is not known.
Galigniana, Mario Daniel, Gallay, Philippe A., Morishima, Yoshihiro, Pratt, William B.   +3 more
core   +2 more sources

Integrating tacrolimus into eutectic oil-based microemulsion for atopic dermatitis: simultaneously enhancing percutaneous delivery and treatment efficacy with relieving side effects

International Journal of Nanomedicine, 2019
Yixuan Wang, Sisi Cao, Kaiyue Yu, Fengdie Yang, Xiuming Yu, Yuanhao Zhai, Chuanbin Wu, Yuehong XuDepartment of Pharmaceutics, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People’s Republic of ChinaBackground: Topical
Wang Y, Cao S, Yu K, Yang F, Yu X, Zhai Y, Wu C, Xu Y   +7 more
doaj  

Effect of High‐Fat Diet on Pharmacokinetics and Incidence of Adverse Reactions of Tacrolimus in Healthy Chinese Participants

Clinical Pharmacology in Drug Development, Volume 15, Issue 3, March 2026.
Abstract The effects of food on the pharmacokinetics (PKs) and safety of 1 mg Tacrolimus sustained‐release Tacrolimus capsules in healthy Chinese subjects were investigated from one bioequivalence trial. The bioequivalence trial was designed as single‐center, openlabel, randomized, single‐dose, two‐sequence, four‐period crossover under both fasted and ...
Xiufang Zhu, Lingxue Shi, Lan Yang, Nana Zhang, Yujie Wu, Peihua Yin, Jianxin Wang, Chunhua Zhou   +7 more
wiley   +1 more source

Recent advances in hepatic transplantation at the University of Pittsburgh. [PDF]

, 1993
FK506 undoubtedly improved the survival advantage of hepatic allotransplantation. Hepatic-intestinal and multivisceral transplantation has also become a feasible therapy for patients with combined intestinal and liver failure.
Abu-Elmagd, K, Bronsther, O, Dodson, F, Doyle, H, Furukawa, H, Irish, W, Jain, A, Marino, IR, Ramos, H, Selby, R   +9 more
core  

Crystal Structure of the FK506 Binding Domain of Plasmodium falciparum FKBP35 in Complex with FK506

Biochemistry, 2008
The emergence of multi-drug-resistant strains of Plasmodium parasites has prompted the search for alternative therapeutic strategies for combating malaria. One possible strategy is to exploit existing drugs as lead compounds. FK506 is currently used in the clinic for preventing transplant rejection.
Ye, H, Alag, R, Hu, G, Preiser, PR, Bozdech, Z, Ho, SY, Lescar, J, Kotaka, M   +7 more
openaire   +5 more sources

Cyclic ADP-Ribose Requires FK506-Binding Protein to Regulate Intracellular Ca2+ Dynamics and Catecholamine Release in Acetylcholine-Stimulated Bovine Adrenal Chromaffin Cells

Journal of Pharmacological Sciences, 2006
.: The present study was undertaken to elucidate whether cyclic ADP-ribose (cADPR) mediates the amplification of Ca2+ signaling and catecholamine release via the involvement of FK506-binding proteins (FKBPs)/ryanodine receptor (RyR) in bovine adrenal ...
Morita Katsuya, Kitayama Tomoya, Kitayama Shigeo, Dohi Toshihiro   +3 more
doaj   +1 more source