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Mutational and topological analysis of Fks1
Echinocandins represent a new antifungal group with potent activity against most Candida and Aspergillus species. These lipopeptides inhibit synthesis of [beta]-1,3-glucan, a major cell wall polysaccharide. Rare acquired resistance is associated with mutations in two "hotspot" regions of Fks1 or Fks2, the probable [beta]-1,3-glucan syntheses. IntrinsicMichael E. Johnson, Thomas D. Edlind
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Mycopathologia
Candida parapsilosis complex has recently received special attention due to naturally occurring FKS1 polymorphism associated with high minimal inhibitory concentrations for echinocandin and the increase of clonal outbreaks of strains resistant to commonly used antifungals such as fluconazole. Despite the previous fact, little is known about the genetic
Hazim O. Khalifa +2 more
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Candida parapsilosis complex has recently received special attention due to naturally occurring FKS1 polymorphism associated with high minimal inhibitory concentrations for echinocandin and the increase of clonal outbreaks of strains resistant to commonly used antifungals such as fluconazole. Despite the previous fact, little is known about the genetic
Hazim O. Khalifa +2 more
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Planta, 2001
A novel plant gene CFL1 was cloned from cotton (Gossypium hirsutum L.) fibers by expressed sequence tag (EST) database searching and 5'-RACE (rapid amplification of cDNA ends). This gene shows sequence homology with FKS1 which has been identified as the putative catalytic subunit of the yeast beta-1,3-glucan synthase.
X, Cui +5 more
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A novel plant gene CFL1 was cloned from cotton (Gossypium hirsutum L.) fibers by expressed sequence tag (EST) database searching and 5'-RACE (rapid amplification of cDNA ends). This gene shows sequence homology with FKS1 which has been identified as the putative catalytic subunit of the yeast beta-1,3-glucan synthase.
X, Cui +5 more
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The new microbiologica, 2014
We describe a case of bloodstream infection caused by a Candida krusei strain that developed echinocandin resistance during caspofungin therapy. Three mutations were found in the HS1 region of the fks1 gene, two of them have never been reported either in C. krusei nor in C. albicans.
A.C.M. Prigitano +5 more
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We describe a case of bloodstream infection caused by a Candida krusei strain that developed echinocandin resistance during caspofungin therapy. Three mutations were found in the HS1 region of the fks1 gene, two of them have never been reported either in C. krusei nor in C. albicans.
A.C.M. Prigitano +5 more
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Susceptibilidade de Candida albicans à Caspofungina e mutações de FKS1
2012A incidência e a prevalência de infecções fúngicas invasivas com comprometimento de vida são um grave problema de saúde humana e, não obstante dos tratamentos antifúngicos agressivos bem estabelecidos ou com novos fármacos, estas infecções são uma causa importante de morbilidade e mortalidade, especialmente em indivíduos imunocomprometidos.
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2023
Linqi Wang, Pengjie Hu
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Linqi Wang, Pengjie Hu
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