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Flagellin as a vaccine adjuvant
Expert Review of Vaccines, 2018 Bacterial flagellin, as a pathogen-associated molecular pattern (PAMP), can activate both innate and adaptive immunity. Its unique structural characteristics endow an effective and flexible adjuvant activity, which allow the design of different types of vaccine strategies to prevent various diseases.
Yuzhen Fang +5 more
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FliS/flagellin/FliW heterotrimer couples type III secretion and flagellin homeostasis [PDF]
Scientific Reports, 2018 AbstractFlagellin is amongst the most abundant proteins in flagellated bacterial species and constitutes the major building block of the flagellar filament. The proteins FliW and FliS serve in the post-transcriptional control of flagellin and guide the protein to the flagellar type III secretion system (fT3SS), respectively.
Florian Altegoer +6 more
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Domain structure of flagellin [PDF]
FEBS Letters, 1984 The chemotaxis of bacteria such as Salmonella and Escherichia coli involves smooth swimming punctuated by periods of tumbling. In smooth swimming the flagellar filaments are left‐handed, in tumbling they are right‐handed with a different wavelength. The filaments are constructed from a globular protein, flagellin, by a process of self‐assembly.
O. V. Fedorov, Alla S. Kostyukova
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Compartmentalized Antimicrobial Defenses in Response to Flagellin [PDF]
Trends in Microbiology, 2018 Motility is often a pathogenicity determinant of bacteria targeting mucosal tissues. Flagella constitute the machinery that propels bacteria into appropriate niches. Besides motility, the structural component, flagellin, which forms the flagella, targets Toll-like receptor 5 (TLR5) to activate innate immunity.
Vijayan, Aneesh +3 more
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Regeneration and defense: unveiling the molecular interplay in plants. [PDF]
New PhytolSummary In both plants and animals, tissue or organ regeneration typically follows wounding, which also activates defense responses against pathogenic microbes and herbivores. Both intrinsic and environmental cues guide the molecular decisions between regeneration and defense.
Xu D, Yang L.
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Journal of Bacteriology, 1977 Flagellins from 17 Caulobacter strains were partially purified. Their molecular weights and immunological properties indicated that a two-component flagellin system is common among Caulobacters.
C, Lagenaur, N, Agabian
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Isolation and characterization of Campylobacter flagellins [PDF]
Journal of Bacteriology, 1987 Sequential acid pH dissociation, differential ultracentrifugation, and neutral pH reassociation were used to partially purify serotypically distinct flagella from three strains of Campylobacter jejuni and the two antigenic phases of flagella of Campylobacter coli VC167. Each C. jejuni flagellin and C.
Logan, S., Harris, L., Trust, T.
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Classification of Bacillus subtilis flagellins [PDF]
Journal of Bacteriology, 1977 Purified flagellins derived from 16 strains of Bacillus subtilis were classified into at least five distinct groups on the basis of their reaction with antiflagellar filament antibody and antiflagellin antibody. This classification was in good accord with that derived independently on the basis of amino acid analyses of the flagellins.
Alexander N. Glazer +4 more
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Journal of Biological Chemistry, 1988 Purified flagellar filaments of Halobacterium halobium contain three different protein species based on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. These proteins were designated as flagellins Fla I, Fla II, and Fla III and were characterized as sulfated glycoproteins with N-glycosidically linked oligosaccharides of the type GlcA-(1----4)
Gerl, L., Sumper, Manfred
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Cloning, Expression, and Purification of Pseudomonas aeruginosa Flagellin, and Characterization of the Elicited Anti-Flagellin Antibody [PDF]
Iranian Red Crescent Medical Journal, 2016 Pseudomonas aeruginosa is an important opportunistic human pathogen that causes serious infections in immunocompromised hosts. The single polar flagellum is an important factor in both virulence and colonization.As flagellin is the major component of the flagellar filament, the main aims of the present study are to identify, clone, express, and purify ...
Mehdi Mahdavi +5 more
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