Results 1 to 10 of about 58,715 (277)

Flagellin co-expression potentiates mRNA vaccine-induced cytotoxic T lymphocyte responses but not anti-tumor immunity [PDF]

Scientific Reports
Personalized neoantigen mRNA vaccine showed high potency to treat advanced melanoma and pancreatic cancer in recent clinical trials. Strategies to further increase its therapeutic efficacy are highly demanded.
Yibo Li, Xinliang Kang, Yuna Song, Labone Akter, Elise VanLuinen, Jayachandra Reddy Nakkala, Xinyuan Chen   +6 more
doaj   +2 more sources

Flagellin induces β-defensin 2 in human colonic ex vivo infection with enterohemorrhagic Escherichia coli [PDF]

, 2016
Enterohemorrhagic E. coli (EHEC) is an important foodborne pathogen in the developed world and can cause life-threatening disease particularly in children.
Chan, Simon, Cook, Vivienne, Ellis, Samuel, Gelson, William, Lewis, Steven, Prior, Alison, Schuller, Stephanie   +6 more
core   +3 more sources

Innate immune detection of flagellin positively and negatively regulates salmonella infection. [PDF]

PLoS ONE, 2013
Salmonella enterica serovar Typhimurium is a flagellated bacterium and one of the leading causes of gastroenteritis in humans. Bacterial flagellin is required for motility and also a prime target of the innate immune system.
Marvin A Lai, Ellen K Quarles, Américo H López-Yglesias, Xiaodan Zhao, Adeline M Hajjar, Kelly D Smith   +5 more
doaj   +3 more sources

Harnessing flagellin of Ligilactobacillus agilis as a surface display scaffold for an HIV-1 epitope [PDF]

Applied and Environmental Microbiology
Lactic acid bacteria (LAB) are promising mucosal vaccine vectors due to their safety, immunostimulatory properties, and the availability of genetic tools for certain strains.
Shunya Suzuki, Gregg A. Dean, Akinobu Kajikawa   +2 more
doaj   +2 more sources

Stenotrophomonas maltophilia provokes NEU1-mediated release of a flagellin-binding decoy receptor that protects against lethal infection

iScience
Summary: Stenotrophomonas maltophilia (Sm), a multidrug-resistant pathogen often isolated from immunocompromised individuals, presents its flagellin to multimeric tandem repeats within the ectodomain of mucin-1 (MUC1-ED), expressed on airway epithelia ...
Erik P. Lillehoj, Yafan Yu, Avelino C. Verceles, Akihiro Imamura, Hideharu Ishida, Kurt H. Piepenbrink, Simeon E. Goldblum   +6 more
doaj   +2 more sources

An immune receptor complex evolved in soybean to perceive a polymorphic bacterial flagellin

Nature Communications, 2020
Ralstonia solanacearum evades plant immunity by producing an atypical flagellin protein, thus causing bacterial wilt disease. Here, Wei et al. show that soybean has evolved a divergent flagellin receptor that recognises R.
José S Rufián, Cécile Segonzac, Rafael Jorge León Morcillo   +2 more
exaly   +2 more sources

Aeromonas hydrophila flagella glycosylation: involvement of a lipid carrier.

PLoS ONE, 2014
Polar flagellin proteins from Aeromonas hydrophila strain AH-3 (serotype O34) were found to be O-glycosylated with a heterogeneous glycan. Mutants unable to produce WecP or Gne enzymes showed altered motility, and the study of their polar flagellin ...
Susana Merino, Kelly M Fulton, Susan M Twine, Markus Wilhelms, Raquel Molero, Juan M Tomás   +5 more
doaj   +4 more sources

Flagellin recognition triggers zinc mobilization in Arabidopsis thaliana as a response to Salmonella Typhimurium invasion. [PDF]

Sci Rep
Mandava TA, Michetti E, Astolfi ML, Camoni L, Battistoni A, Visconti S, Ammendola S.   +6 more
europepmc   +3 more sources

Transgenic expression of the dicotyledonous pattern recognition receptor EFR in rice leads to ligand-dependent activation of defense responses [PDF]

, 2015
Plant plasma membrane localized pattern recognition receptors (PRRs) detect extracellular pathogen-associated molecules. PRRs such as Arabidopsis EFR and rice XA21 are taxonomically restricted and are absent from most plant genomes.
A Afroz, A Daudi, A Heese, A Keller, AP Macho, AP Macho, Arsalan Daudi, B Schulze, B Schwessinger, B Schwessinger, Benjamin Schwessinger, BM Lee, BMJ Mendes, C Segonzac, C Zipfel, C-J Park, C-J Park, Christopher Daum, Christopher J. Petzold, CJ Park, CJ Park, CJ Park, CR Clarke, Cyril Zipfel, D Chinchilla, D Chinchilla, D Chinchilla, D Kim, D Lu, Deling Ruan, DJ McCarthy, E Fradin, F Lu, G Felix, G Kunze, G Qian, H Haweker, H Hirai, H Ochiai, H Schoonbeek, H Wickham, H Zhang, J Li, J Li, J Monaghan, J Zhang, JD Jones, JF González, JN Tripathi, Joshua L. Heazlewood, K Kishimoto, L Trdá, LA Boyd, M Albert, M Boudsocq, M Boudsocq, M Lopez-Gomez, M Roux, Mansi Chovatia, MD Robinson, MS Chern, N Holton, Nicolas Holton, Nicolas Thomas, O Bahar, Ofir Bahar, P Schulze-Lefert, Pamela C. Ronald, Patrick E. Canlas, PC Ronald, R Cai, R De Jonge, R Lozano-Durán, R Sharma, R Takai, Rita Kuo, S Lacombe, S Tan, S Wang, S Zuo, SH Spoel, SL Salzberg, ST Chisholm, SW Lee, T Boller, T Furukawa, T Maekawa, T Nakagawa, T Xiang, V Nekrasov, Vasanth R. Singan, Vladimir Nekrasov, W Liu, Wenbo Ma, WY Song, WY Song, X Chen, X Chen, X Chen, X Chen, Y Ao, Y Hiei, Y Jiang, Y Kadota, Y Katsuragi, Y Kawahara, Y Kawano, Y Peng, Y Saijo, Y Saijo, Y Xiang, YS Seo, YS Wang   +112 more
core   +23 more sources

Vascular Adhesion Protein 1 Mediates Gut Microbial Flagellin-Induced Inflammation, Leukocyte Infiltration, and Hepatic Steatosis

Sci, 2021
Toll-like receptor 5 ligand, flagellin, and vascular adhesion protein 1 (VAP-1) are involved in non-alcoholic fatty liver disease. This study aimed to determine whether VAP-1 mediates flagellin-induced hepatic fat accumulation.
Raine Toivonen, Sanja Vanhatalo, Maija Hollmén, Eveliina Munukka, Anniina Keskitalo, Sami Pietilä, Laura Elo, Pentti Huovinen, Sirpa Jalkanen, Satu Pekkala   +9 more
doaj   +1 more source