Sci, 2021 Toll-like receptor 5 ligand, flagellin, and vascular adhesion protein 1 (VAP-1) are involved in non-alcoholic fatty liver disease. This study aimed to determine whether VAP-1 mediates flagellin-induced hepatic fat accumulation.
Raine Toivonen +9 more
doaj +1 more source
Luminal-applied flagellin is internalized by polarized intestinal epithelial cells and elicits immune responses via the TLR5 dependent mechanism. [PDF]
PLoS ONE, 2011 Bacteria release flagellin that elicits innate responses via Toll-like receptor 5 (TLR5). Here, we investigated the fate of apically administrated full length flagellin from virulent and avirulent bacteria, along with truncated recombinant flagellin ...
Tonyia Eaves-Pyles +6 more
doaj +1 more source
Intraluminal Flagellin Differentially Contributes to Gut Dysbiosis and Systemic Inflammation following Burn Injury. [PDF]
PLoS ONE, 2016 Burn injury is associated with a loss of gut barrier function, resulting in systemic dissemination of gut-derived bacteria and their products. The bacterial protein and TLR5 agonist, flagellin, induces non-specific innate immune responses.
Logan Grimes +7 more
doaj +1 more source
A rapid change in virulence gene expression during the transition from the intestinal lumen into tissue promotes systemic dissemination of Salmonella. [PDF]
, 2010 Bacterial pathogens causing systemic disease commonly evolve from organisms associated with localized infections but differ from their close relatives in their ability to overcome mucosal barriers by mechanisms that remain incompletely understood.
Andrews-Polymenis, Helene L. +7 more
core +17 more sources
Subtilase SBT5.2 inactivates flagellin immunogenicity in the plant apoplast. [PDF]
Nat CommunMost angiosperm plants recognise the 22-residue flagellin (flg22) epitope in bacterial flagellin via homologs of cell surface receptor FLS2 (flagellin sensitive-2) and mount pattern-triggered immune responses.
Buscaill P +9 more
europepmc +2 more sources
mTORC1 Regulates Flagellin-Induced Inflammatory Response in Macrophages. [PDF]
PLoS ONE, 2015 Bacterial flagellin triggers inflammatory responses. Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) regulate the production of pro- and anti-inflammatory cytokines that are induced by extrinsic antigens, but the function of ...
Wenlei Bao +8 more
doaj +1 more source
Involvement of Flagellin in Kin Recognition between Bacillus velezensis Strains
mSystems, 2022 Kin discrimination in nature is an effective way for bacteria to stabilize population cooperation and maintain progeny benefits. However, so far, the research on kin discrimination for Bacillus still has concentrated on “attack and defense” between cells
Yan Liu +8 more
doaj +1 more source
Salmonella Flagellin Activates NAIP/NLRC4 and Canonical NLRP3 Inflammasomes in Human Macrophages
Journal of Immunology, 2020 Key Points Salmonella infection leads to NAIP/NLRC4 and NLRP3 inflammasome activation. Flagellin activates the NAIP/NLRC4 and NLRP3 inflammasome in human macrophages.
A. M. Gram +6 more
semanticscholar +1 more source
Molecular Medicine Reports, 2020 Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD), which is a chronic, relapsing condition associated with the disorder of gut microbial communities.
Xing Wu +9 more
semanticscholar +1 more source
Bonded straight and helical flagellar filaments form ultra-low-density glasses [PDF]
, 2022 We study how the three-dimensional shape of rigid filaments determines the microscopic dynamics and macroscopic rheology of entangled semi-dilute Brownian suspensions. To control the filament shape we use bacterial flagella, which are micron-long helices assembled from flagellin monomers. We compare the dynamics of straight rods, helical filaments, and
arxiv +1 more source