Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection. [PDF]
, 2006 To restrict infection by Legionella pneumophila, mouse macrophages require Naip5, a member of the nucleotide-binding oligomerization domain leucine-rich repeat family of pattern recognition receptors, which detect cytoplasmic microbial products.
Byrne, Brenda G +6 more
core +2 more sources
TLR5 activation in respiratory epithelial cells orchestrate mucosal Th17 response through both indirect and direct pathways. [PDF]
Respir ResBackground Flagellin, a potent mucosal adjuvant administered via the intranasal route, has been widely recognized for its capacity to enhance immune responses against diverse pathogens.
Huang S +10 more
europepmc +2 more sources
Directed Evolution of FLS2 towards Novel Flagellin Peptide Recognition. [PDF]
PLoS ONE, 2016 Microbe-associated molecular patterns (MAMPs) are molecules, or domains within molecules, that are conserved across microbial taxa and can be recognized by a plant or animal immune system.
Laura Helft +2 more
doaj +1 more source
NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo. [PDF]
, 2016 NLRs (nucleotide-binding domain [NBD] leucine-rich repeat [LRR]-containing proteins) exhibit diverse functions in innate and adaptive immunity.
Al Moussawi, Khatoun +7 more
core +1 more source
Frontiers in Immunology, 2020 Bacteria-released components can modulate host innate immune response in the absence of direct host cell–bacteria interaction. In particular, bacteria-derived outer membrane vesicles (OMVs) were recently shown to activate host caspase-11-mediated non ...
Jungmin Yang +6 more
semanticscholar +1 more source
Flagellin induces β-defensin 2 in human colonic ex vivo infection with enterohemorrhagic Escherichia coli [PDF]
, 2016 Enterohemorrhagic E. coli (EHEC) is an important foodborne pathogen in the developed world and can cause life-threatening disease particularly in children.
Chan, Simon +6 more
core +1 more source
Innate immune detection of flagellin positively and negatively regulates salmonella infection. [PDF]
PLoS ONE, 2013 Salmonella enterica serovar Typhimurium is a flagellated bacterium and one of the leading causes of gastroenteritis in humans. Bacterial flagellin is required for motility and also a prime target of the innate immune system.
Marvin A Lai +5 more
doaj +1 more source
Pseudomonas aeruginosa pilin activates the inflammasome [PDF]
, 2011 IL-1 beta is produced from inactive pro-IL-1 beta by activation of caspase-1 brought about by a multi-subunit protein platform called the inflammasome. Many bacteria can trigger inflammasome activity through flagellin activation of the host protein NLRC4.
Agostini +54 more
core +1 more source
Enterotoxigenic Escherichia coli induce pro-inflammatory responses in porcine intestinal epithelial cells [PDF]
, 2010 F4+ enterotoxigenic Escherichia coli (ETEC) cause severe diarrhoea in both neonatal and weaning piglets, resulting in morbidity and mortality. F4 fimbriae are a key virulence factor involved in the attachment of F4+ ETEC to the intestinal epithelium ...
Cox, Eric +4 more
core +1 more source
A self-adjuvanted nanoparticle based vaccine against infectious bronchitis virus. [PDF]
PLoS ONE, 2018 Infectious bronchitis virus (IBV) affects poultry respiratory, renal and reproductive systems. Currently the efficacy of available live attenuated or killed vaccines against IBV has been challenged.
Jianping Li +7 more
doaj +1 more source