Results 41 to 50 of about 58,715 (277)

Flagellin Encoded in Gene-Based Vector Vaccines Is a Route-Dependent Immune Adjuvant. [PDF]

PLoS ONE, 2016
Flagellin has been tested as a protein-based vaccine adjuvant, with the majority of studies focused on antibody responses. Here, we evaluated the adjuvant activity of flagellin for both cellular and humoral immune responses in BALB/c mice in the setting ...
Hamada F Rady, Guixiang Dai, Weitao Huang, Judd E Shellito, Alistair J Ramsay   +4 more
doaj   +1 more source

NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo. [PDF]

, 2016
NLRs (nucleotide-binding domain [NBD] leucine-rich repeat [LRR]-containing proteins) exhibit diverse functions in innate and adaptive immunity.
Al Moussawi, Khatoun, Kang, Chulho, Kang, James J, Kazmierczak, Barbara I, Nichols, Randilea D, Rauch, Isabella, Tenthorey, Jeannette L, Vance, Russell E   +7 more
core   +1 more source

A Salmonella virulence factor activates the NOD1/NOD2 signaling pathway. [PDF]

, 2011
The invasion-associated type III secretion system (T3SS-1) of Salmonella enterica serotype Typhimurium (S. Typhimurium) activates the transcription factor NF-κB in tissue culture cells and induces inflammatory responses in animal models through unknown ...
Bäumler, Andreas J, Keestra, A Marijke, Kim, Anita, Klein-Douwel, Daisy, Tsolis, Renée M, Winter, Maria G, Winter, Sebastian E, Xavier, Mariana N   +7 more
core   +2 more sources

Identification and characterisation of enteroaggregative Escherichia coli subtypes associated with human disease [PDF]

, 2020
Enteroaggregative E. coli (EAEC) are a major cause of diarrhoea worldwide. Due to their heterogeneity and carriage in healthy individuals, identification of diagnostic virulence markers for pathogenic strains has been difficult.
Brett, Bernard, Bundy, Leah, Chattaway, Marie A., Crossman, Lisa C., Ellis, Samuel J., Hölken, Johanna M., Kay, Gemma L., McGrath, Conor J., Schüller, Stephanie, Wain, John   +9 more
core   +1 more source

Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity [PDF]

, 2009
Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates.
AG Barbour, AG Barbour, AG Barbour, AG Barbour, AS Coleman, C Neeleman, C Siegel, C Skerka, CA Brissette, Christiane Brenner, CS Brooks, D Raoult, David M. Ojcius, DJ Grab, E Rossmann, E Rossmann, GD Wieland, H Fuchs, J Bunikis, JA Gebbia, JC Scott, JC Setubal, JL Coleman, JV McDowell, K Hartmann, KM Hovis, KM Hovis, KO Sundnes, L Houhamdi, Markus M. Simon, MD Kramer, Melanie Schott, MK Pangburn, NM Ras, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Stewart, Peter F. Zipfel, Peter Kraiczy, PF Zipfel, PF Zipfel, PM Southern, RD Horstmann, Reinhard Wallich, S Hammerschmidt, S Kuhn, S Kuhn, S Poltermann, S Ram, Sally J. Cutler, SH Rooijakkers, SJ Cutler, Sonja Grosskinsky, T Meri, T Meri, WR Zuckert   +59 more
core   +12 more sources

Pseudomonas evades immune recognition of flagellin in both mammals and plants.

PLoS Pathogens, 2011
The building blocks of bacterial flagella, flagellin monomers, are potent stimulators of host innate immune systems. Recognition of flagellin monomers occurs by flagellin-specific pattern-recognition receptors, such as Toll-like receptor 5 (TLR5) in ...
Bart W Bardoel, Sjoerd van der Ent, Michiel J C Pel, Jan Tommassen, Corné M J Pieterse, Kok P M van Kessel, Jos A G van Strijp   +6 more
doaj   +1 more source

Rapid Preparation of Unsheathed Bacterial Flagella

Bio-Protocol, 2015
The flagellum is required for bacterial swimming and swarming motility. In the biphasic Salmonella enterica serovar Typhimurium (S. Typhimurium), the flagellar filament is build up by two distinct monomeric subunits, flagellin FliC and FljB.
Soazig Le Guyon, Mikael Rhen, Ute Römling   +2 more
doaj   +1 more source

Enterotoxigenic Escherichia coli induce pro-inflammatory responses in porcine intestinal epithelial cells [PDF]

, 2010
F4+ enterotoxigenic Escherichia coli (ETEC) cause severe diarrhoea in both neonatal and weaning piglets, resulting in morbidity and mortality. F4 fimbriae are a key virulence factor involved in the attachment of F4+ ETEC to the intestinal epithelium ...
Cox, Eric, Devriendt, Bert, Goddeeris, Bruno, Stuyven, Edith, Verdonck, Frank   +4 more
core   +1 more source

Pseudomonas aeruginosa pilin activates the inflammasome [PDF]

, 2011
IL-1 beta is produced from inactive pro-IL-1 beta by activation of caspase-1 brought about by a multi-subunit protein platform called the inflammasome. Many bacteria can trigger inflammasome activity through flagellin activation of the host protein NLRC4.
Agostini, Andersen-Nissen, Arora, Auron, Bergsbaken, Bird, Bitter, Case, Choi, Cornelis, Craig, Dinarello, Evans, Franchi, Franchi, Franchi, Hahn, Hazes, Hsu, Johnson, Kanneganti, Kus, Lightfield, Lindestam Arlehamn, Liu, Marathe, Mariathasan, Mariathasan, Martinon, Martinon, Mattick, Miao, Miao, Miao, Murray, Muruve, Neyt, O'Neill, Perkins, Pier, Proft, Sato, Sato, Sawa, Schroeder, Semmler, Smedley, Sutterwala, Sutterwala, Thornberry, Ting, Vallis, von Götz, Ye, Yu   +54 more
core   +1 more source

NLRC4 Inflammasome-Driven Immunogenicity of a Recombinant MVA Mucosal Vaccine Encoding Flagellin

Frontiers in Immunology, 2018
Bacterial flagellin enhances innate and adaptive immune responses and is considered a promising adjuvant for the development of vaccines against infectious diseases and cancer.
Stephanie L. Sanos, Ronny Kassub, Marco Testori, Marlene Geiger, Juliane Pätzold, Raphael Giessel, Johanna Knallinger, Barbara Bathke, Fabienne Gräbnitz, Kay Brinkmann, Paul Chaplin, Mark Suter, Hubertus Hochrein, Henning Lauterbach   +13 more
doaj   +1 more source