Predictive modeling of influenza strain drugs using temperature-based topological indices and regression analysis via multi-criteria decision making techniques. [PDF]
Sci RepHayat H +3 more
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Development and application of <i>in-vivo</i> dose and time-resolved measurements for clinical application of ultra-high dose rate radiotherapy. [PDF]
Phys Imaging Radiat OncolDal Bello R +10 more
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Structural Tuning of Inefficient <i>C</i> <sub>1</sub>‑Symmetric Iodoarene for Efficient Enantioselective Oxidative Organocatalysis. [PDF]
ACS OmegaPavankumar K +4 more
europepmc +1 more source
Radiation shielding and safety implications following linac conversion to an electron FLASH‐RT unit
Medical Physics, 2021 AbstractPurposeDue to their finite range, electrons are typically ignored when calculating shielding requirements in megavoltage energy linear accelerator vaults. However, the assumption that 16 MeV electrons need not be considered does not hold when operated at FLASH‐RT dose rates (~200× clinical dose rate), where dose rate from bremsstrahlung photons
Poirier, Yannick +7 more
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Electron flash-RT program in clinical setting for human translation.
Journal of Clinical Oncology, 2022e13596 Background: A FLASH-RT program was established at Dartmouth-Hitchcock Medical Center in minimally-modified clinical setting by joint efforts of biomedical engineering, radiation oncology, radiation biology and medical physics teams. Various projects on dosimetry, chemical sensing, molecular profiling, software/hardware development, and ...
Rongxiao Zhang +7 more
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Beam Diagnostics for FLASH RT in the Varian ProBeam System
2022FLASH RT is a novel ultra-high dose rate radiation therapy technique with the potential of sparing radiation induced damages to healthy tissue while keeping tumor control unchanged. Recent studies indicate that this so-called FLASH effect occurs when applying high doses of several Grays in a fraction of a second only, and thus significantly faster than
Schedler, Manuel +2 more
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Testing Proton FLASH RT in Bone Mets
Cancer Discovery, 2022Abstract Findings from FAST-01, a first-in-human trial of proton FLASH radiotherapy, indicate that this approach is safe and seems as effective as conventional radiation in relieving pain from bone metastases in the arms and legs, with no additional or unexpected toxicity.
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News FLASH-RT: To Treat GBM and Spare Cognition, Fraction Size and Total Dose Matter
Clinical Cancer Research, 2021Abstract Data indicate that ultrahigh dose rate (>106 Gy/second) FLASH radiotherapy (FLASH-RT) delivery of radiation reduces normal tissue damage without compromising tumor response. Orthotopic glioblastoma mouse studies now demonstrate that radiation fraction size, total dose, and number of fractions are critical parameters for ...
Christina C, Huang, Marc S, Mendonca
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