FLASH Radiotherapy Versus Conventional Cancer Therapy: Promises, Paradoxes and Problems
A novel means of applying radiotherapy in cancer treatment is the application of a radiation dose at a very high intensity for a very short time in FLASH radiotherapy (FLASH-RT).
Stephen C. Bondy
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FLASH radiotherapy (FLASH-RT), characterized by ultra-high dose rates (>40 Gy/s), has demonstrated remarkable normal tissue-sparing effects in preclinical models while maintaining tumor control.
Yixue Wen +5 more
semanticscholar +1 more source
Potential effect of FLASH radiotherapy on testicular damage: a review of current evidence
Radiotherapy is a major source of ionizing radiation that adversely affects the male reproductive system. FLASH radiotherapy (FLASH-RT), a novel technique delivering ultra-high dose rate (UHDR) radiation, has shown promise in reducing normal tissue ...
Xiaoyu Zhi +10 more
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Alanine dosimetry based on Electron Paramagnetic Resonance (EPR) spectroscopy has been a reliable reference and transfer dosimetry method in high-dose applications, valued for its high precision, accuracy and long-term stability.
Babedi Sebinanyane +4 more
semanticscholar +1 more source
Development of in situ dosimetry for FLASH proton radiotherapy via organic scintillating fibers. [PDF]
Olson C +4 more
europepmc +1 more source
Global clinical landscape and multidisciplinary translational frontiers of FLASH radiotherapy: a systematic review and visualized bibliometric mapping based on WoSCC and PubMed (2014-2025). [PDF]
Di Y, Liu C, Wang Y, Cai B, Meng L.
europepmc +1 more source
Harnessing the sparing effect of FLASH-RT: From phenomenon observation, radiophysical determinants to molecular mechanisms and synergistic strategies. [PDF]
Dou Z +9 more
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Antitumor Activity of Combined Topoisomerase Inhibition and FLASH Radiotherapy in Head and Neck Carcinoma Biomodels. [PDF]
Sarogni P +17 more
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Novel Bragg peak FLASH radiotherapy: treatment of base-of-skull tumors within existing clinical guidelines. [PDF]
Pennock M +12 more
europepmc +1 more source
Precise delineation of radiation targets for thoracic tumors in the immunotherapy era: From immune mechanisms to clinical practice. [PDF]
Chen X, Yi M, Deng Y, Shen Q.
europepmc +1 more source

