Results 81 to 90 of about 5,736 (170)

No differences in therapeutic efficacy while sparing healthy tissue for orthotopic glioblastoma patient-derived xenografts in context of proton FLASH

Clinical and Translational Radiation Oncology
Ultra-high dose rate (FLASH-RT) and conventional proton beam radiotherapy to intracranial glioblastoma PDX were compared for tumor control and normal tissue toxicity via DNA and RNA damage response markers.
Taylor L. Schanel, Manoj Kumar, Lauren C. Nassour-Caswell, Sreelakshmi Cherakara, Rhea Pandit, Andee M. Beierle, Joshua C. Anderson, Patrica H. Hicks, Rex Cardan, Anita B. Hjelmeland, Christopher D. Willey   +10 more
doaj   +1 more source

First-in-human e-Flash radiotherapy using a modified conventional C-arm linear accelerator

Clinical and Translational Radiation Oncology
Highlights • First treatment of a patient by e-Flash radiotherapy with a modified conventional C-arm linear accelerator.• Detailed technical description including hardware, treatment planning, quality assurance, and dosimetry summary.• Overview of ...
J. von der Grün, R. Dal Bello, S. Psoroulas, J. Krayenbuehl, Debra Fesslmeier, E. Ramelyte, J. Mangana, W. Smith, M. Vilalta, Lena Tirpak, Ricky A. Sharma, Matthias Guckenberger, S. Tanadini-Lang, P. Balermpas   +13 more
semanticscholar   +1 more source

Toward online dose reconstruction in phantom using deep learning-based X-ray-induced acoustic imaging for X-ray FLASH radiotherapy

Nuclear Engineering and Technology
FLASH radiotherapy (FLASH-RT) is an emerging radiation therapy technique that delivers ultra-high radiation doses within an extremely short time frame, ensuring effective tumor control while significantly reducing damage to normal tissues.
Xulin Hu, Junling Wang, Dai Wu, Liuyuan Zhou, Yi Zhang, Jianwen Huo   +5 more
doaj   +1 more source

One‐year follow‐up after fractionated ultra‐high‐dose‐rate FLASH radiotherapy in patient with extramammary Paget disease of the scrotum

Precision Radiation Oncology
Objective Ultrahigh‐dose‐rate radiotherapy (FLASH‐RT) has been shown to reduce radiation‐induced normal tissue injury in preclinical studies. Here, we describe the first patient worldwide to receive fractionated FLASH‐RT.
Hui Luo, Chengliang Yang, Ronghu Mao, Leijie Ma, Hongchang Lei, Peng Chen, Yanping Zhang, Meng Xu, Chao Wang, Yiwu Wang, Mingxia Wu, Chanjun Sun, Han Liu, Hui Liu, Hong Ge   +14 more
doaj   +1 more source

FLASH radiotherapy effects: From physicochemical foundations to preclinical models -- a review

Journal of Radiation Research and Applied Sciences
The ultimate goal pursued in the field of oncology therapy is to maximize the control of lesions while reducing normal tissue damage. FLASH radiotherapy (FLASH-RT) is a new radiotherapy technology mainly characterized by ultra-high dose rate irradiation (
YuLong He, Ting Ren
doaj   +1 more source

FLASH radiotherapy: bridging revolutionary mechanisms and clinical frontiers in cancer treatment – a narrative review

The Ewha Medical Journal
FLASH radiotherapy (FLASH-RT) is an innovative approach that delivers ultra-high dose rates exceeding 40 Gy in less than a second, aiming to widen the therapeutic window by minimizing damage to normal tissue while ...
Jae Sik Kim, Hak Jae Kim
doaj   +1 more source

Radiation safety of ultra‐high dose rate electron accelerators for FLASH radiotherapy

Medical Physics (Lancaster)
An ultra‐high dose rate (UHDR) electron accelerator for FLASH radiotherapy (RT) produces very intense bremsstrahlung by the interaction of the electron beam with objects both inside and outside of the accelerator.
Lars Hjorth Præstegaard
semanticscholar   +1 more source

A feasibility study of preclinical ocular x-ray FLASH radiotherapy

International Journal of Radiation Oncology, Biology, Physics
Introduction: Ultra-high dose-rate radiotherapy (FLASH-RT) has not previously been studied for the treatment of ocular targets. This work describes the feasibility of ocular FLASH irradiation of a single mouse eye utilizing kV x-ray sources with rotating
D. Miles, Daniel M. Sforza, M. Cano, Cornelia Peterson, Kathleen L. Gabrielson, John W. Wong, J. Handa, M. Rezaee   +7 more
semanticscholar   +1 more source

Leveraging the Immune Response from LIFE Biomaterial and Photon-Flash in Pre-Clinical Pancreatic Cancer Treatment

Pharmaceutics
Pre-clinical animal studies evaluating the ‘flash effect’ caused by ultra-high dose rate (≥40 Gy/s) favorably spares normal tissue from radiation-caused toxicity while maintaining anti-tumor effects like conventional (CONV) radiation.
Michele Moreau, Katelyn Kelly, Serena Mao, Debarghya China, Girmachew Wasihun, Aditya Pandya, MohammadAli Tajik-Mansoury, Daniel Sforza, Devin Miles, Amol K. Narang, Mohammad Rezaee, Wilfred Ngwa, Kai Ding   +12 more
doaj   +1 more source

FLASH radiotherapy at a crossroads: a bibliometric perspective on progress and challenges

Discover Oncology
Background Flash radiotherapy (FLASH-RT), an emerging modality utilizing ultra-high dose-rate (UHDR) irradiation (typically > 40 Gy/s), has demonstrated a unique capacity to preserve normal tissue integrity while maintaining tumor control efficacy ...
Peng Wang, Yugeng Gao, Can Chen, Xiaoxin Zhao, Yuying Zhang, Taorui Liu, Haoran Jiang, Zhe Wang, Xiang Zhao, Jianjun Li   +9 more
doaj   +1 more source