Results 71 to 80 of about 5,736 (170)

FLASH Radiotherapy: Expectations, Challenges, and Current Knowledge

International Journal of Molecular Sciences
Major strides have been made in the development of FLASH radiotherapy (FLASH RT) in the last ten years, but there are still many obstacles to overcome for transfer to the clinic to become a reality.
Andrea Borghini, L. Labate, S. Piccinini, Costanza Maria Vittoria Panaino, M. Andreassi, L. Gizzi   +5 more
semanticscholar   +1 more source

Towards Clinical Translation: Establishing Optimal Dose and Dose-Rate Parameters for the FLASH Skin-Sparing Effect

Dose-Response
Purpose FLASH radiotherapy (FLASH-RT) has been reported to spare skin from acute radiation toxicity. However, systematic quantification is needed to determine the dose and dose-rate thresholds necessary for optimal radioprotection in FLASH radiotherapy ...
Yufeng Shen, Jie Zhou, Jinyi Lang, Lintao Li, Yongjie Li, Chenxi Yang, Shuo Wang, Xiaohua Chen, Siyu Xie, Wei Tang, Shun Lu   +10 more
doaj   +1 more source

Infrared microspectroscopy to elucidate the underlying biomolecular mechanisms of FLASH radiotherapy.

Radiotherapy and Oncology
BACKGROUND FLASH-radiotherapy (FLASH-RT) is an emerging modality that uses ultra-high dose rates of radiation to enable curative doses to the tumor while preserving normal tissue.
I. Martínez-Rovira, Pierre Montay-Gruel, B. Petit, Ron J. Leavitt, R. González-Vegas, Pascal Froidevaux, M. Juchaux, Y. Prezado, I. Yousef, M. Vozenin   +9 more
semanticscholar   +1 more source

The FLASH effect—an evaluation of preclinical studies of ultra-high dose rate radiotherapy

Frontiers in Oncology
FLASH radiotherapy (FLASH-RT) is a novel radiotherapy approach based on the use of ultra-high dose radiation to treat malignant cells. Although tumours can be reduced or eradicated using radiotherapy, toxicities induced by radiation can compromise ...
Josie May McGarrigle, Kenneth Richard Long, Kenneth Richard Long, Yolanda Prezado, Yolanda Prezado   +4 more
doaj   +1 more source

FLASH radiotherapy spares lymphocytes in tumor-draining lymph nodes and increases infiltration of immune cells in tumors

bioRxiv
Radiotherapy (RT) delivered at conventional dose rates (CONV) can both stimulate antitumor immune responses and inhibit these immune responses by depleting circulating lymphocytes.
F. Saenz, B. Velasquez, T. Waldrop, E. Aguilar, Kathryn R. Cox, Abagail M. Delahoussaye, Caddie Laberiano-Fernandez, L. C. Clemente, L. Connell, Nefetiti Mims, D. Neill, Edwin R. Parra, K. Clise-Dwyer, E. Schüler, Michael T. Spiotto   +14 more
semanticscholar   +1 more source

Time-dependent alterations in brain metabolites and gut microbiota following whole-brain FLASH versus conventional radiotherapy in mice

Brain Research Bulletin
Purpose: This study compared the time-dependent changes in brain metabolites and gut microbiota at early and late post-irradiation stages in mice receiving conventional radiotherapy (CONV-RT) or ultra-high dose-rate FLASH radiotherapy (FLASH-RT). Methods:
Renke He, Yuhan Liu, Wenxuan Li, Shengqiang Xie, Jiayu Liu, Gang Cheng, Jianning Zhang   +6 more
doaj   +1 more source

Comprehensive dosimetric characterization of novel silicon carbide detectors with UHDR electron beams for FLASH radiotherapy

Medical Physics (Lancaster)
Background: The extremely fast delivery of doses with ultra high dose rate (UHDR) beams necessitates the investigation of novel approaches for real‐time dosimetry and beam monitoring.
G. Milluzzo, M. De Napoli, F. Di Martino, A. Amato, D. Del Sarto, M. D'Oca, M. Marrale, L. Masturzo, E. Medina, C. Okpuwe, J. Pensavalle, A. Vignati, M. Camarda, Francesco Romano   +13 more
semanticscholar   +1 more source

State-of-the-art silicon carbide diode dosimeters for ultra-high dose-per-pulse radiation at FLASH radiotherapy

Physics in Medicine and Biology
Objective. The successful implementation of FLASH radiotherapy in clinical settings, with typical dose rates >40 Gy s−1, requires accurate real-time dosimetry. Approach.
C. Fleta, G. Pellegrini, P. Godignon, Faustino Gómez Rodríguez, J. Paz‐Martín, R. Kranzer, A. Schüller   +6 more
semanticscholar   +1 more source

Investigating the Oxygen Dependence of FLASH-RT using Electron Paramagnetic Resonance Imaging

Radiotherapy and Oncology
Purpose: The FLASH effect occurs when radiation given at ultra-high dose rates spares healthy tissue while achieving isoeffective tumor control relative to conventional (CONV) dose rate irradiation. Limited data has implicated oxygen in the FLASH effect.
T. Waldrop, Grace Murley, Brett Velasquez, E. Konradsson, D. Neill, L. Connell, Alan Lopez Hernandez, Abagail M. Delahoussaye, F. Schuler, Jorge de la Cerda, Ziyi Li, Mark D. Pagel, E. Schüler   +12 more
semanticscholar   +1 more source

Dosimetric characterization of an encapsulated waterproof silicon carbide detector with UHDR electron and proton beams for FLASH radiotherapy

Physics in Medicine and Biology
Silicon carbide (SiC) detectors have been widely demonstrated to be suitable alternative detectors for dosimetry in FLASH radiotherapy, showing radiation hardness and dose-rate independence at the FLASH radiotherapy instantaneous dose rates (IDRs ...
G. Milluzzo, D. Zitelli, Andrea Cavalieri, M. Celentano, F. Di Martino, L. Masturzo, C. Okpuwe, J. Pensavalle, S. Lorentini, E. Scifoni, F. Tommasino, Annalisa Trianni, G. Trovato, E. Verroi, A. Quaranta, M. Camarda, Francesco Romano   +16 more
semanticscholar   +1 more source