Results 61 to 70 of about 5,736 (170)

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, Volume 13, Issue 55, 5 October 2026.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

Randomized phase II selection trial of FLASH and conventional radiotherapy for patients with localized cutaneous squamous cell carcinoma or basal cell carcinoma: A study protocol

Clinical and Translational Radiation Oncology
Background: Cutaneous basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most prevalent skin cancers in western countries. Surgery is the standard of care for these cancers and conventional external radiotherapy (CONV-RT) with ...
Rémy Kinj, Olivier Gaide, Wendy Jeanneret-Sozzi, Urania Dafni, Stéphanie Viguet-Carrin, Enea Sagittario, Magdalini Kypriotou, Julie Chenal, Frederic Duclos, Marine Hebeisen, Teresa Falco, Reiner Geyer, Patrik Gonçalves Jorge, Raphaël Moeckli, Jean Bourhis   +14 more
doaj   +1 more source

MICA Allelic Variation Modulates Secretion and Protein Flexibility, Impacting on NKG2D‐Mediated Immune Responses and Antibody Detection

European Journal of Immunology, Volume 56, Issue 10, October 2026.
Differential secretion mechanisms and predicted structural flexibility are described as additional effects of MICA polymorphism in the immune response. Structural features might explain impaired antibody recognition of certain MICA alleles, supporting that MICA genotyping should be considered in biomarker studies and NKG2D‐based therapeutic development.
Silvia López‐Borrego, Karen Toledo‐Stuardo, Douglas J. Matthies, Marta González‐Matesanz, María Carmen Molina, Mar Valés‐Gómez   +5 more
wiley   +1 more source

METTL3 Alleviates Liver Abscess by Enhancing Macrophage Efferocytosis via m6A Methylation of Nrf2 mRNA

Immunity, Inflammation and Disease, Volume 14, Issue 10, October 2026.
ABSTRACT Background Persistent inflammation and impaired macrophage efferocytosis contribute to liver injury during bacterial liver abscesses (BLA). This study was conducted to investigate whether METTL3 alleviates BLA by promoting macrophage efferocytosis through m6A methylation of Nrf2 mRNA. Materials and Methods METTL3 was overexpressed in the liver
Genwang Wang, Ding Luo, Yu Pang, Chanjuan Gao, Dong Jin, Qi Wang   +5 more
wiley   +1 more source

Machine stability and dosimetry for ultra‐high dose rate FLASH radiotherapy human clinical protocol

Journal of Applied Clinical Medical Physics
Background The FLASH effect, induced by ultra‐high dose rate (UHDR) irradiations, offers the potential to spare normal tissue while effectively treating tumors.
Patrik Gonçalves Jorge, Reiner Geyer, R. Kinj, Luis Schiappacasse, W. Jeanneret-Sozzi, J. Bourhis, F. Herrera, F. Bochud, C. Bailat, R. Moeckli   +9 more
semanticscholar   +1 more source

Interleukin‐35 Ameliorates Obesity‐Associated Impairment of Endothelium‐Dependent Vasodilation via the STAT3‐MAPK/ERK‐eNOS Signaling Axis

Immunity, Inflammation and Disease, Volume 14, Issue 10, October 2026.
ABSTRACT Background Obesity impairs endothelial nitric oxide synthase (eNOS)‐nitric oxide (NO) signaling, triggering chronic inflammation, endothelial dysfunction and defective vasodilation, which drives cardiometabolic diseases. Existing metabolic therapies provide only indirect vascular protection and fail to resolve residual inflammatory‐mediated ...
Kai Li, Jie Feng, Ren Gong, Yunman Liu, Yanqing Wu   +4 more
wiley   +1 more source

Key Considerations for Treatment Planning System Development in Electron and Proton FLASH Radiotherapy

Quantum Beam Science
The global cancer burden continues to increase worldwide. Among the various treatment options, radiotherapy (RT), which employs high-energy ionizing radiation to destroy cancer cells, is one of the primary modalities for cancer.
Chang Cheng, Gaolong Zhang, Nan Li, Xinyu Hu, Zhen Huang, Xiaoyu Xu, Shouping Xu, Weiwei Qu   +7 more
doaj   +1 more source

Mechanisms of the FLASH effect: current insights and advances

Frontiers in Cell and Developmental Biology
Radiotherapy is a fundamental tool in cancer treatment, utilized in over 60% of cancer patients during their treatment course. While conventional radiotherapy is effective, it has limitations, including prolonged treatment durations, which extend patient
Giulia Rosini, Esther Ciarrocchi, Esther Ciarrocchi, Esther Ciarrocchi, Beatrice D’Orsi, Beatrice D’Orsi, Beatrice D’Orsi   +6 more
doaj   +1 more source

Preferential Tumor Vascular Damage is the Common Anti-Tumor Mechanism of High-Dose Hypo-Fractionated Radiotherapy: SABR, SFRT, FLASH-RT.

International Journal of Radiation Oncology, Biology, Physics, 2023
C. Song, S. Terezakis, W. Park, S. Paek, Mi-Sook Kim, L. Cho, R. Griffin   +6 more
semanticscholar   +1 more source

FLASH radiotherapy using high-energy X-rays: validation of the Flash effect triggered by a compact device.

International Journal of Radiation Oncology, Biology, Physics
PURPOSE This study investigated whether the Flash effect could be triggered using a compact single high-energy X-ray source (CHEXs) FLASH radiotherapy (FLASH-RT) with or without two 30-second pauses during irradiation in mice. METHODS The integral dose
B. Lin, Huan Du, Yi-Wei Yang, Xiaofei Hao, Feng Gao, Yuwen Liang, Wenqiang Tang, Haonan Xu, Mingming Tang, Yao Liao, Decai Wang, Bo Lin, Yihan Zhu, Ting-Ting Wang, Run-Qiu Gu, Xin Mao, Yi-Xiao He, Yu Zhang, Jie Li, Zheng Zhou, Jianxin Wang, Dai Wu, Xiao-Bo Du   +22 more
semanticscholar   +1 more source