Results 41 to 50 of about 5,736 (170)

Influence factor and mechanism of FLASH effect

Frontiers in Oncology
FLASH radiotherapy (FLASH-RT) represents an innovative treatment modality utilizing ultra-high dose-rate irradiation (>40 Gy/s). The FLASH effect, induced by FLASH-RT, is characterized by the selective radioprotective effect of normal tissue while ...
Tingyu Feng, Tingyu Feng, Tianyang He, Wentao Ye, Lisha Xiang   +4 more
doaj   +1 more source

An insight into hypothesized biological mechanisms contributing to the Flash effect

Frontiers in Physics, 2023
In recent years, FLASH radiotherapy (FLASH RT) has gained attention in preclinical studies as a potential advancement in cancer treatment. The great advantage of FLASH RT is the ultra-fast, high doses delivery that have a similar or greater effect on ...
Francesca Del Debbio, Maria Sofia Bertilacchi, Alessandra Gonnelli, Alessandra Gonnelli, Eleonora Da Pozzo, Eleonora Da Pozzo, Eleonora Da Pozzo, Valentina Tozzini, Valentina Tozzini, Claudia Martini, Claudia Martini, Claudia Martini, Simone Capaccioli, Simone Capaccioli, Simone Capaccioli, Barbara Costa, Barbara Costa   +16 more
doaj   +1 more source

A20 Inhibits IFN‐γ Signaling in Hepatocellular Carcinoma Cells by Binding to STAT1, Compromising Anti‐Tumor Immunity

Cancer Science, EarlyView.
A20 suppresses IFN‐γ signaling in HCC cells by binding to STAT1 through its ZnF7 domain, thereby reducing CXCL9, CXCL10, and HLA‐ABC expression, ultimately impairing CD8+ T‐cell‐mediated anti‐tumor immunity. ABSTRACT Immune checkpoint blockade (ICB) has demonstrated efficacy in clinical cancer therapy; however, a significant proportion of cancer ...
Yanlei Dong, Jing Yi, Ruoxuan Yang, Yingyue Wang, Zelong Ma, Hong Yuan, Meichen Song, Ying Xiao, Chun Guo, Jianing Wang, Xiaoyan Wang, Faliang Zhu, Lining Zhang, Yuchen Fan, Yongyu Shi   +14 more
wiley   +1 more source

Tissue-specific iron levels modulate lipid peroxidation and the FLASH radiotherapy effect

Cell Death and Disease
Iron is vital to living cells, playing a key role in cellular respiration, DNA synthesis, and various metabolic functions. Importantly, cancer cells have a higher dependency on iron compared to normal cells to support their rapid growth and survival. Due
Nuria Vilaplana-Lopera, Jiyoung Kim, Gilyeong Nam, Iain D C Tullis, S. Paillas, Jia-Ling Ruan, Pei-Ju Lee, Yanyan Jiang, Sohee Park, Tianxu Hou, Ayesha Nasir, Eve Charlesworth, E. Walker, Ammar Abu-Halawa, M. A. Hill, Changhoon Choi, Ik Jae Lee, Youngtae Jeong, S. Lakhal-Littleton, C. Then, Shing-Chuan Shen, A. Giaccia, Kristoffer Petersson, Eui Jung Moon   +23 more
semanticscholar   +1 more source

The influence of beam parameters on FLASH effect

Frontiers in Oncology
Ultra-high dose rate radiotherapy (FLASH-RT) is typically defined as an external beam radiotherapy that utilizes a dose rate of 40 Gy/s or higher, compared with conventional dose rate radiotherapy (≤0.1 Gy/s).
Binwei Lin, Binwei Lin, Huan Du, Huan Du, Xiaofei Hao, Xiaofei Hao, Yuwen Liang, Haonan Xu, Wenqiang Tang, Jie Li, Jie Li, Yu Zhang, Yu Zhang, Xiao Bo Du, Xiao Bo Du, Xiao Bo Du   +15 more
doaj   +1 more source

Spatially Resolved Metabolomics of Optimal Cutting Temperature (OCT) Compound‐Embedded Tumors

International Journal of Cancer, Volume 159, Issue 12, Page 3038-3048, 15 December 2026.
ABSTRACT Mass spectrometry imaging (MSI) is emerging as a powerful tool for uncovering the distribution of metabolites in the tumor microenvironment and studying tumor metabolism in vivo. To date, MSI of biobanked tissues contextualized by patient data has been limited to peptides, proteins, and glycans—with few examples for metabolites.
Joseph Monaghan, Nicholas Woytowich, Tian Zhao, Kiera Nguyen, Emily Mahony, Julian J. Lum, Kyle D. Duncan   +6 more
wiley   +1 more source

FLASH radiotherapy: Research process from basic experimentation to clinical application

Precision Radiation Oncology, 2021
FLASH radiotherapy (FLASH‐RT) has gained attention as an ultra‐high dose rate RT in recent years. This treatment significantly shortens the time of RT and reduces the influence of tumor movement caused by breathing or other factors.
Xiaohui Wang, Hui Luo, Xiaoli Zheng, Hong Ge   +3 more
doaj   +1 more source

Radiobiological Aspects of FLASH Radiotherapy

Biomolecules, 2022
Radiotherapy (RT) is one of the primary treatment modalities for cancer patients. The clinical use of RT requires a balance to be struck between tumor effect and the risk of toxicity.
Eline Hageman, Pei-Pei Che, Max Dahele, Ben J. Slotman, Peter Sminia   +4 more
doaj   +1 more source

Radiation‐Induced Skin Injury in Cancer Radiotherapy: From Mechanisms to Management

Advanced Oncology, Volume 1, Issue 1, December 2026.
Radiation‐induced skin injuries (RISI) remain a significant challenge faced by cancer patients receiving radiotherapy (RT). This perspective article examines the pathophysiology of RISI and evaluates the currently existing and emerging therapeutic strategies, including stem cell‐derived exosomes and advanced hydrogels.
Zeynep Meral Toutoungi, Nukhet Aykin‐Burns, Jingyi Chen, Younghye Song   +3 more
wiley   +1 more source

Comparable survival in rats with intracranial glioblastoma irradiated with single-fraction conventional radiotherapy or FLASH radiotherapy

Frontiers in Oncology
BackgroundRadiotherapy increases survival in patients with glioblastoma. However, the prescribed dose is limited by unwanted side effects on normal tissue.
Emma Liljedahl, Elise Konradsson, Karin Linderfalk, Emma Gustafsson, Kristoffer Petersson, Kristoffer Petersson, Crister Ceberg, Henrietta Nittby Redebrandt, Henrietta Nittby Redebrandt   +8 more
doaj   +1 more source