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FLASH Radiotherapy: History and Future
Frontiers in Oncology, 2021 The biological effects of radiation dose to organs at risk surrounding tumor target volumes are a major dose-limiting constraint in radiotherapy. This can mean that the tumor cannot be completely destroyed, and the efficacy of radiotherapy will be ...
Binwei Lin +7 more
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Effects on hematopoietic and immune system of ultra-high dose rate radiotherapy (FLASH-RT).
JCO Global Oncology, 2023 166 Background: Ultra-high dose rate radiotherapy, so-called FLASH radiotherapy (FLASH-RT) has shown to reduce radiation-induced damage including lung fibrosis, brain damage, skin fibrosis, etc.
Tosol Yu, Min-Young Choi
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Key changes in the future clinical application of ultra-high dose rate radiotherapy
Frontiers in Oncology, 2023 Ultra-high dose rate radiotherapy (FLASH-RT) is an external beam radiotherapy strategy that uses an extremely high dose rate (≥40 Gy/s). Compared with conventional dose rate radiotherapy (≤0.1 Gy/s), the main advantage of FLASH-RT is that it can reduce ...
Binwei Lin +6 more
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The importance of hypoxia in radiotherapy for the immune response, metastatic potential and FLASH-RT
International Journal of Radiation Biology, 2021 Purpose Hypoxia (low oxygen) is a common feature of solid tumors that has been intensely studied for more than six decades. Here we review the importance of hypoxia to radiotherapy with a particular focus on the contribution of hypoxia to immune ...
Eui Jung Moon, K. Petersson, M. Olcina
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Flash Radiotherapy: Innovative Cancer Treatment
Encyclopedia, 2023 Flash radiotherapy (Flash-RT) is an innovative technique used in radiotherapy for cancer treatment because it delivers an extremely high dose of radiation (>40 Gy/s) to the tumour in a very short period of time, typically within a fraction of a second ...
James C. L. Chow, Harry E. Ruda
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Scientific Reports, 2022 Radiotherapy can induce an immunological response. One limiting factor is side effects on normal tissue. Using FLASH radiotherapy, side effects could possibly be reduced.
Emma Liljedahl +6 more
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Clinical and Translational Radiation Oncology, 2023 Background/Purpose: Investigating the antitumor effect and intratumor as well as local immune response in breast cancer-bearing mice after MV X-ray ultra-high dose rate radiotherapy (FLASH-RT) and conventional dose rate radiotherapy (CONV-RT).
Hongyu Zhu +12 more
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Radiation Medicine and Protection, 2020 Different from conventional radiotherapy (CONV-RT), FLASH radiotherapy (FLASH-RT) delivers a single high dose at a mean dose rate ≥40 Gy/s in milliseconds to achieve similar tumor control to CONV-RT while sparing normal tissues from detrimental injury ...
Guangming Zhou
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A review of the impact of FLASH radiotherapy on the central nervous system and glioma
Radiation Medicine and Protection, 2022 Glioma has received considerable attention because of its potential of inducing high rates of morbidity, disability, and mortality. FLASH radiotherapy (FLASH-RT) has emerged as a popular topic in current research because of its ability to protect normal ...
Lin Li, Yayi Yuan, Yahui Zuo
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Design, Construction, and Test of Compact, Distributed-Charge, X-Band Accelerator Systems that Enable Image-Guided, VHEE FLASH Radiotherapy [PDF]
Frontiers of PhysicsThe design and optimization of laser-Compton x-ray systems based on compact distributed charge accelerator structures can enable micron-scale imaging of disease and the concomitant production of beams of Very High Energy Electrons (VHEEs) capable of ...
C. Barty +42 more
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