Results 11 to 20 of about 5,736 (170)

A safety study of ultra‐high dose rate FLASH radiotherapy in the treatment of superficial skin tumors: study protocol of a phase I trial (ChiCTR2400080935)

Precision Radiation Oncology
Objective Ultra‐high dose rate FLASH radiotherapy (FLASH‐RT) is emerging as a novel technique to improve the normal tissue tolerance by delivering ultra‐high dose rate radiation several orders of magnitude higher than convention radiotherapy. It has been
Chengliang Yang, Hui Luo, Ma Leijie, Ronghu Mao, Hongchang Lei, Yanping Zhang, Meng Xu, Yiwu Wang, Mingxia Wu, Han Liu, Peng Chen, Hong Ge   +11 more
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Preliminary mechanistic study of mitochondrial function in intestinal protection mediated by high-energy X-ray FLASH radiotherapy [PDF]

Radiation Oncology
Purpose Ultra-high dose rate (UHDR) radiation retains tumor-killing efficacy while mitigating toxicity to normal tissues, holding a promising transformative radiotherapy paradigm.
Xiaofei Hao, Huan Du, Binwei Lin, Decai Wang, Wei Wu, Mingming Tang, Huayan Zhang, Yihan Zhu, Yu Zhang, Yiwei Yang, Xiaobo Du   +10 more
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Research progresses on FLASH radiotherapy and its application for the treatment of digestive system tumors [PDF]

Discover Oncology
Over the past decades, advances in technique have turned radiotherapy into a precise and effective modality for cancer treatment. Nevertheless, the biological effect on organs surrounding the tumor target area is a main dose-limiting element in ...
Siqian Zhang, Yongsheng Zhang, Zhifei Cao   +2 more
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FLASH radiotherapy and immunotherapy synergy: mechanisms, strategies, and clinical translation prospects [PDF]

Frontiers in Immunology
FLASH radiotherapy (FLASH-RT), characterized by ultra-high dose rate irradiation (≥40 Gy/s), has generated substantial interest in radiation oncology due to its reported capacity to preserve normal tissues while maintaining tumor control—a phenomenon ...
Qianyi Liu, Xianhu Zeng, Yongze He, Linsen Zhou, Ying Tang, Shuotong Liu, Xiaobin Wang, Shiyan Shen, Jialin Ji, Zhen Liu, Jiangping Li   +10 more
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The Biophysics of Flash Radiotherapy: Tools for Measuring Tumor and Normal Tissues Microenvironment

Antioxidants
Ultra-high dose rate radiotherapy known as Flash radiotherapy (FLASH-RT) offers tremendous opportunities to improve the therapeutic ratio of radiotherapy by sparing the normal tissue while maintaining similar tumoricidal efficacy. However, the underlying
Islam G. Ali, Issam El Naqa
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Mechanisms of Action in FLASH Radiotherapy: A Comprehensive Review of Physicochemical and Biological Processes on Cancerous and Normal Cells

Cells
The advent of FLASH radiotherapy (FLASH-RT) has brought forth a paradigm shift in cancer treatment, showcasing remarkable normal cell sparing effects with ultra-high dose rates (>40 Gy/s).
James C. L. Chow, Harry E. Ruda
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Exploring the mechanisms of protective effect of high-energy X-ray FLASH radiotherapy on intestine through multi omics analysis

Radiation Oncology
Background The aim of this study is to investigate the potential mechanisms underlying the protective effects of high-energy X-ray FLASH radiotherapy (FLASH-RT) on intestine through multi-omics analysis.
Huan Du, Binwei Lin, Yihan Zhu, Xiaofei Hao, Mingming Tang, Wei Wu, Decai Wang, Yiwei Yang, Yuwen Liang, Wenqiang Tang, Haonan Xu, Jie Li, Feng Gao, Xiaobo Du   +13 more
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FLASH radiotherapy preserves systemic and tissue homeostasis while maintaining antitumor efficacy [PDF]

BMC Medicine
Background Conventional radiotherapy (CONV-RT) is widely used for cancer treatment, but its efficacy is limited by toxicity to surrounding healthy tissues.
Giulia Furini, Eduarda Mota da Silva, Alice Usai, Gaia Scabia, Claudia Kusmic, Francesco Faita, Andrea Cavalieri, Mariagrazia Celentano, Mario Costa, Filippo Rossi, Giulia Asero, Roberta Di Pietro, Emanuela Guerra, Stefano Lattanzio, Tonia Luca, Sergio Castorina, Roberto Cusano, Riccardo Berutti, Jessica Milia, Simone Capaccioli, Alessandra Gonnelli, Noemi Giannini, Fabiola Paiar, Saverio Cinti, Fabio Di Martino, Margherita Maffei   +25 more
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The evolution of FLASH radiotherapy: a bibliometric analysis

Frontiers in Oncology
IntroductionFLASH radiotherapy (FLASH-RT) represents a groundbreaking technique, characterized by its ultra-high dose rate and its remarkable ability to spare normal tissues from damage. Numerous studies on FLASH-RT have been conducted worldwide. However,
Shuokai Jia, Shuokai Jia, Weige Wei, Weige Wei, Yiwen He, Haichuan Yan, Shiru Zou, Yanmei Hao, Yanmei Hao, Qing Xiao, Qing Xiao, Guangjun Li, Guangjun Li   +12 more
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Mechanisms of FLASH effect

Frontiers in Oncology, 2022
FLASH radiotherapy (FLASH-RT) is a novel radiotherapy technology defined as ultra-high dose rate (≥ 40 Gy/s) radiotherapy. The biological effects of FLASH-RT include two aspects: first, compared with conventional dose rate radiotherapy, FLASH-RT can ...
Binwei Lin, Binwei Lin, Dan Huang, Feng Gao, Yiwei Yang, Dai Wu, Yu Zhang, Gang Feng, Tangzhi Dai, Xiaobo Du   +9 more
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