Efficacy of Radiotherapy FLASH-RT: From Treating Lung Cancer to Preventing Pulmonary Fibrosis
Dose-ResponseFLASH radiotherapy (FLASH-RT) is a radiotherapy technique that achieves ultra-high dose rates in a fraction of a second. Based on data from experimental animal models, FLASH-RT appears to protect a number of normal tissues from radiation-induced damage ...
Tianyu Yang +4 more
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Expert consensus on clinical trial design guidelines for FLASH radiotherapy. [PDF]
Precis Radiat Oncol• FLASH radiotherapy has emerged as a transformative technology due to the underlying FLASH effect. • As FLASH radiotherapy moves toward clinical application, establishing standardized trial design principles is critical. • This expert consensus provides a roadmap for rigorous clinical evaluation of FLASH radiotherapy, accelerating safe translation of ...
Luo H +9 more
europepmc +2 more sources
FLASH radiotherapy as an emerging paradigm in radioimmunotherapy: biological rationale, preclinical evidence, and translational roadmap [PDF]
Frontiers in ImmunologyUltra-high dose rate radiotherapy (FLASH-RT) has emerged as a promising technology in recent years. Unlike conventional radiotherapy (CONV-RT), FLASH-RT delivers radiation at an ultra-high dose rate over a very short duration.
Dongliang Li +8 more
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Evaluation of a Faraday cup-style detector as a beam diagnostic system for ultra-high dose rate (FLASH) electron beams. [PDF]
J Appl Clin Med PhysAbstract Background Beam diagnostic systems are essential for the development and quality assurance of ultra‐high dose rate (UHDR) radiation sources to enable reliable delivery of FLASH radiotherapy (RT). Critically, suitable beam diagnostic systems for electron FLASH sources are lacking.
Lopez A +5 more
europepmc +2 more sources
FLASH radiotherapy preserves hepatic function and maintains metabolic homeostasis in a murine breast cancer model: an experimental preclinical study [PDF]
Radiation OncologyBackground Radiotherapy (RT) for treating breast cancer can result in incidental dose deposition to the liver, leading to functional impairment. FLASH radiotherapy (FLASH-RT), delivered at ultra-high dose rates (UHDR), has demonstrated remarkable normal ...
Xingyu Lu +4 more
doaj +2 more sources
Dosimetry for FLASH Radiotherapy: A review of dosimetric systems
Brazilian Journal of Radiation SciencesFLASH radiotherapy (FLASH-RT) is a promising approach to cancer treatment, characterized by the delivery of high doses of radiation in a short period of time, within fractions of seconds.
Karoline Feitoza Suzart +1 more
doaj +2 more sources
Precision Radiation OncologyUltra‐high dose rate FLASH Radiotherapy (FLASH‐RT) has attracted wide attention because the well‐known FLASH effect and the extremely short irradiation time.
Hui Luo +3 more
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Reduced corneal toxicity following whole brain irradiation in mice [PDF]
Clinical and Translational Radiation OncologyPurpose: The emergence of focal techniques such as stereotactic radiosurgery has led to a more selective use of whole brain radiotherapy (WBRT), yet it remains an important modality for treating diffuse or multiple intracranial malignancies. During WBRT,
Vinoshene Pillai +8 more
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X‑ray FLASH RT inhibits lung cancer bone metastasis via activating CD4⁺ T-cell‑mediated antitumor immunity with modulation of Th17 cell response [PDF]
OncoImmunologyLung cancer is characterized by rapid progression and poor prognosis, with 50%–70% of patients presenting local or distant metastasis at diagnosis, among which bone metastasis is the most common type.
Yao Huang +12 more
doaj +2 more sources
FLASH Radiotherapy: Mechanisms of Biological Effects and the Therapeutic Potential in Cancer
BiomoleculesRadiotherapy is an important treatment for many unresectable advanced malignant tumors, and radiotherapy-associated inflammatory reactions to radiation and other toxic side effects are significant reasons which reduce the quality of life and survival of ...
Ouying Yan +3 more
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