Results 51 to 60 of about 5,736 (170)

Simulation study of a novel small animal FLASH irradiator (SAFI) with integrated inverse-geometry CT based on circularly distributed kV X-ray sources

Scientific Reports, 2023
Ultra-high dose rate (UHDR) radiotherapy (RT) or FLASH-RT can potentially reduce normal tissue toxicity. A small animal irradiator that can deliver FLASH-RT treatments similar to clinical RT treatments is needed for pre-clinical studies of FLASH-RT.
Yuewen Tan, Shuang Zhou, Jonathan Haefner, Qinghao Chen, Thomas R. Mazur, Arash Darafsheh, Tiezhi Zhang   +6 more
doaj   +1 more source

Development of Radioiodinated Tetrahydropyrazolopyridine Inhibitors Targeting mIDH

Journal of Labelled Compounds and Radiopharmaceuticals, Volume 69, Issue 13-14, November-December 2026.
Iodinated tetrahydropyrazolopyridine ligands show enhanced potency and selectivity for mutant IDH1 compared with their fluorinated counterparts and can be efficiently radiolabeled with I‐125, supporting the basis for further evaluation as mIDH1‐targeting radiotheranostic candidates.
Sarandeep Kaur, Sladjana Dukic‐Stefanovic, Lucie Arnaud, Jean‐Michel Chezal, Barbara Wenzel, Rareş‐Petru Moldovan, Klaus Kopka, Aurélie Maisonial‐Besset   +7 more
wiley   +1 more source

Dosimetry characteristics of ultra-high dose rate X-ray: a short review

Frontiers in Physics
FLASH radiotherapy (FLASH-RT) has emerged as a significant area of research in the field of radiotherapy in recent years. This innovative technology delivers ultra-high dose rate radiation in a very short time, effectively damaging tumor cells while ...
Luyan Tao, Song Feng, Yiwei Yang, Bo Zheng   +3 more
doaj   +1 more source

Dynamic control of carbon‐ion radiation dose distribution amid respiratory motion challenges: A review of prediction research using geant4 and deep learning physics‐constrained models

Journal of Applied Clinical Medical Physics, Volume 27, Issue 11, November 2026.
Abstract Background Carbon ion radiotherapy (CIRT) offers superior dose conformity and biological effectiveness; however, its precision is highly sensitive to respiratory motion, leading to dose uncertainty and interplay effects that compromise treatment accuracy.
Jianhua Ding, Peng Li, Chai Hong Yeong
wiley   +1 more source

Factors Influencing the Biological Effects of FLASH Irradiation

Antioxidants
Among the methods for increasing the specificity of tumor radiotherapy, FLASH radiotherapy (FLASH-RT) stands out, having recently entered clinical trials.
Sergey Igorevich Glukhov, Elena Ananievna Kuznetsova, Sergey Vsevolodovich Akulinichev   +2 more
doaj   +1 more source

Experimental verification of the applicability of the AQURE IOERT accelerator for FLASH radiotherapy

Polish Journal of Medical Physics And Engineering
Introduction: FLASH radiotherapy is based on delivering an ultra-high dose of ionizing radiation in a very short time, which allows for the enhanced protection of healthy tissues and the effective destruction of tumour tissues.
A. Lenartowicz-Gasik, A. Misiarz, Przemysław Adrich, S. Wronka, T. Piotrowski, B. Pawałowski, Piotr Nowaczyk, Jan Trzuskowski, Jacek Rzadkiewicz   +8 more
semanticscholar   +1 more source

A technology‐specific risk analysis of surface guided radiation therapy

Journal of Applied Clinical Medical Physics, Volume 27, Issue 10, October 2026.
Abstract Background Surface Guided Radiation Therapy (SGRT) has become an increasingly important tool that complements x‐ray imaging to improve patient safety for setup, respiratory tracking, and motion monitoring. As SGRT is integrated into clinical workflows, its complexity can introduce potential risk of process‐related errors.
Victoria Bry, Angelia Tran, Tamara Egan, Eric Ford, Juergen Meyer   +4 more
wiley   +1 more source

Exploring the role of intestinal microbiota in mitigating acute radiation-induced intestinal injury through high-energy X-ray FLASH radiotherapy via metagenomic analysis

Frontiers in Microbiology
ObjectivesThis study preliminarily examines the potential correlation between the gut microbiome and the protective effects of FLASH radiotherapy (FLASH-RT) on intestinal tissue using metagenomic analysis.MethodsCompact single high-energy X-ray source ...
Huan Du, Xiaofei Hao, Binwei Lin, Binwei Lin, Binwei Lin, Yihan Zhu, Yihan Zhu, Yihan Zhu, Yiwei Yang, Mingming Tang, Wei Wu, Decai Wang, Decai Wang, Decai Wang, Bo Lin, Bo Lin, Bo Lin, Yuwen Liang, Wenqiang Tang, Haonan Xu, Jie Li, Jie Li, Jie Li, Feng Gao, Feng Gao, Xiaobo Du, Xiaobo Du, Xiaobo Du   +27 more
doaj   +1 more source

Cell‐Free DNA as a Biomarker of Cell Death and Treatment Response for On‐Chip Three‐Dimensional Tumor Models

Advanced Healthcare Materials, Volume 15, Issue 40, 27 October 2026.
This study presents quantifying cell‐free DNA (cfDNA) as a non‐disruptive and rapidly quantifiable method for assessing cell death for on‐chip 3D sarcoma tumor models. On‐chip cfDNA release reflects tumor burden, extent of cell death, and survival of in vitro and ex vivo 3D models, providing valuable insight into the temporal response of tumor models ...
Maryam Ziaee, Julie Lafontaine, Badr Id Said, Kousha Kamal, Kim Tsoi, Francis Rodier, Thomas Gervais, Philip Wong   +7 more
wiley   +1 more source

FLASH Radiotherapy Enhances the Therapeutic Ratio in an Embryonic In Vivo Model of Pancreatic Carcinoma

ACS Applied Materials and Interfaces
Radiotherapy (RT) is a commonly employed treatment in oncological setting. Unfortunately, the therapeutic dose required for tumor control often induces significant side effects in normal tissues, leading to suboptimal outcomes and reduced patient quality
N. Giannini, A. Gonnelli, G. Gadducci, Paola Puccini, Andrea Cavalieri, L. Masturzo, J. Pensavalle, M. Celentano, F. Di Martino, Federico di Cocco, C. Scatena, A. Naccarato, Michele Menicagli, P. Sarogni, V. Frusca, D. Cioni, G. D. Aquaro, Valerio Voliani, F. Paiar   +18 more
semanticscholar   +1 more source