Dual-Role Ubiquitination Regulation Shuttling the Entire Life Cycle of the Flaviviridae [PDF]
Frontiers in Microbiology, 2022 Ubiquitination is a reversible protein post-translational modification that regulates various pivotal physiological and pathological processes in all eukaryotes.
Dongjie Cai +12 more
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Modulation of Lipid Droplet Metabolism—A Potential Target for Therapeutic Intervention in Flaviviridae Infections [PDF]
Frontiers in Microbiology, 2017 Lipid droplets (LDs) are endoplasmic reticulum (ER)-related dynamic organelles that store and regulate fatty acids and neutral lipids. They play a central role in cellular energy storage, lipid metabolism and cellular homeostasis.
Yun Lan, Sumana Sanyal
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Proposed Update to the Taxonomy of Pestiviruses: Eight Additional Species within the Genus Pestivirus, Family Flaviviridae [PDF]
Viruses, 2021 Pestiviruses are plus-stranded RNA viruses belonging to the family Flaviviridae. They comprise several important pathogens like classical swine fever virus and bovine viral diarrhea virus that induce economically important animal diseases.
Alexander Postel +2 more
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Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens [PDF]
Nature, 2016 The Flaviviridae are a family of viruses that cause severe human diseases. For example, dengue virus (DENV) is a rapidly emerging pathogen causing an estimated 100 million symptomatic infections annually worldwide. No approved antivirals are available to
Andreas S Puschnik +2 more
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PLoS Neglected Tropical Diseases, 2022 BackgroundViruses of the family Flaviviridae, including Japanese encephalitis virus (JEV), dengue virus (DENV), yellow fever virus (YFV) and hepatitis C virus (HCV), are widely distributed worldwide.
Ran Wang +6 more
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Mapping glycoprotein structure reveals Flaviviridae evolutionary history [PDF]
NatureViral glycoproteins drive membrane fusion in enveloped viruses and determine host range, tissue tropism and pathogenesis1. Despite their importance, there is a fragmentary understanding of glycoproteins within the Flaviviridae2, a large virus family that
Jonathon C O Mifsud +2 more
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Innate Immune Evasion Mediated by Flaviviridae Non-Structural Proteins
Viruses, 2017 Flaviviridae-caused diseases are a critical, emerging public health problem worldwide. Flaviviridae infections usually cause severe, acute or chronic diseases, such as liver damage and liver cancer resulting from a hepatitis C virus (HCV) infection and ...
Shun Chen, Mingshu Wang, Anchun Cheng
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European College of Equine Internal Medicine consensus statement on equine flaviviridae infections in Europe [PDF]
Journal of Veterinary Internal Medicine, 2022 Horses and other equids can be infected with several viruses of the family Flaviviridae, belonging to the genus Flavivirus and Hepacivirus. This consensus statement focuses on viruses with known occurrence in Europe, with the objective to summarize the ...
Jessika‐M. V. Cavalleri +6 more
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Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation
Viruses, 2022 Members of the Flaviviridae family are posing a significant threat to human health worldwide. Many flaviviruses are capable of inducing severe inflammation in humans.
Anastasia Latanova +2 more
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Flaviviridae Viruses and Oxidative Stress: Implications for Viral Pathogenesis [PDF]
Oxidative Medicine and Cellular Longevity, 2019 Oxidative stress is induced once the balance of generation and neutralization of reactive oxygen species (ROS) is broken in the cell, and it plays crucial roles in a variety of natural and diseased processes.
Zhenzhen Zhang, Rong Liang, Yi‐Ping Li
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