Results 1 to 10 of about 19,854 (89)

Identification of novel neutralizing determinants for protection against HCV

Hepatology, EarlyView., 2022
Identification of novel neutralizing determinants for protection against hepatitis C virus. Abstract Background and Aims HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine.
Garazi P. Alzua, Anne F. Pihl, Anna Offersgaard, Rodrigo Velázquez‐Moctezuma, Carlos R. Duarte Hernandez, Elias H. Augestad, Ulrik Fahnøe, Christian K. Mathiesen, Henrik Krarup, Mansun Law, Jannick Prentoe, Jens Bukh, Judith M. Gottwein   +12 more
wiley   +1 more source

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source

Come together: Data sharing to support one health responses to vector‐borne disease threats

Medical and Veterinary Entomology, EarlyView.
A One Health framework integrating diverse data across human, animal and environmental sectors is essential for effective surveillance and response is vital for responding to vector‐borne disease risks. Communities adopting global data standards, depositing data in shared repositories, and responsible data use can significantly improve VBD data ...
Francis Windram, Sarah Kelly, Stanislav Modrak, Isabelle Dietrich, Corrado Minetti, Karen L. Mansfield, Frederik Seelig, Adam M. Fisher, Maisie Vollans, Nina Billows, Fahad Ahmed, Marta Shocket, Susana Campino, Scott Tytheridge, Sara L. Gandy, Estela Gonzalez, Jolyon M. Medlock, Matthew Baylis, Grant L. Hughes, David A. Ewing, Bethan V. Purse, Georgia Kirby, Clare Strode, Arran J. Folly, David Starns, Heather Ferguson, Simon Smith‐Mullally, Helen Roberts, Christopher M. Jones, Hannah Rose Vineer, Marion England, Christopher Sanders, Samraat Pawar, William D. Pearse, Steven M. White, Robert T. Jones, Lauren J. Cator   +36 more
wiley   +1 more source

Impact of bauxite mining on mosquito communities (Diptera: Culicidae) and pathogen transmission risks in the eastern Amazon

Medical and Veterinary Entomology, EarlyView.
Bauxite mining in the Amazon alters mosquito communities, favouring anthropophilic and generalist vectors while reducing species diversity and the variety of blood meal sources. Molecular analyses identified humans, tapirs and deer as the primary blood meal sources.
Mayron Mielly Morais Pacheco, Poliana da Silva Lemos, Mônica Silva Coelho, Tatiane Marques Porangaba de Oliveira, Luciano Chaves Franco Filho, Øystein Wiig, Ana Cristina Mendes‐Oliveira, Leonardo Sena, Maria Anice Mureb Sallum   +8 more
wiley   +1 more source

Virus‐specific alterations in placental structure and transporter expression following maternal arbovirus infection

The Journal of Physiology, EarlyView.
Abstract figure legend Arboviruses induce virus‐specific alterations in placental structure and functional markers. Chikungunya virus (CHIKV) exposure was associated with reduced syncytiotrophoblast and syncytial knot areas, increased cytotrophoblast proliferation (Ki‐67) and thyroid transporter (MCT8) expression, reduced protective (P‐gp and BCRP ...
Cherley B. V. Andrade, Enrrico Bloise, Natália L. Silva, Jair R. S. Braga, Sharton V. A. Coelho, Veronica M. O. Nascimento, Guinever E. Imperio, Camila O. S. Nunes, Antônio J. L. A. Cunha, Marcelo A. Pascoal‐Xavier, Luciana B. Arruda, Arnaldo Prata‐Barbosa, Kristin L. Connor, Tania M. Ortiga‐Carvalho   +13 more
wiley   +1 more source

Evidence of West Nile Virus Infections in Wild Boars (Sus scrofa) in the Netherlands, 2018–2021

Zoonoses and Public Health, Volume 73, Issue 7, Page 670-679, November 2026.
ABSTRACT Introduction Orthoflaviviruses are emerging in Europe and have potential significant impact on animal and public health. Usutu virus (USUV) and West Nile virus (WNV) have been first detected in the Netherlands in 2016 and 2020, respectively. Wild boars (Sus scrofa) have been suggested as an interesting population to detect the circulation of ...
Kiki Streng, Eduardo de Freitas Costa, Sophie van Oort, Renate Hakze‐van der Honing, Gebbiena Bron, Carl Andreas Grøntvedt, Wim H. M. van der Poel, Nathanaël Hozé, Michel Counotte   +8 more
wiley   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, Volume 13, Issue 10, Page 2138-2142, October 2026.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Thiazolidine‐2,4‐dione and Thiazole Derivatives as Privileged Structures for Dengue Virus: A Review of Medicinal Chemistry Aspects

ChemistrySelect, Volume 11, Issue 37, 6 October 2026.
This graphical abstract summarizes thiazole, thiazolidine‐2,4‐dione, and hybrid compounds investigated as antiviral candidates against dengue virus. Representative structures and reported potencies are presented in the context of DENV serotypes. Proposed molecular targets include NS2B–NS3 protease and NS5.
Pedro César de Souza, Thaynara Paula Warren Bezerra, Matheus Vinicius Guimarães de Melo, Thayná da Silva Barros, Matheus Italo da Conceição, Michelle Melgarejo da Rosa, Moacyr Jesus Barreto de Melo Rêgo   +6 more
wiley   +1 more source

Maltase 1 regulates DENV2 infection and life history in Aedes aegypti

Insect Science, Volume 33, Issue 5, Page 1834-1844, October 2026.
Our study employed CRISPR/Cas9 to generate a MAL1 knockout strain of Aedes aegypti, demonstrating that the absence of MAL1 significantly suppresses DENV2 replication in the midgut and impairs viral transmission. The mutation also altered life‐history (hatching/pupation/emerging rates and sex‐specific survival), identifying MAL1 as a novel target for ...
Man‐Jin Li, Jin Cheng, Ya‐Ming Zou, Quan‐Chao Liu, Ding Zhu, Ce‐Jie Lan   +5 more
wiley   +1 more source

Membrane‐Permeable Nucleoside T‐1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides

Chemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier, Duan Li, Leentje Persoons, Graciela Andrei, Robert Snoeck, Dominique Schols, Lieve Naesens, Xiao Jia   +7 more
wiley   +1 more source