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Virus-Like Particle Systems for Vaccine Development against Viruses in the Flaviviridae Family

open access: yesVaccines, 2019
Viruses in the Flaviviridae family are important human and animal pathogens that impose serious threats to global public health. This family of viruses includes emerging and re-emerging viruses, most of which are transmitted by infected mosquito or tick ...
Shu Hui Wong   +5 more
doaj   +4 more sources

Innate Immune Evasion Mediated by Flaviviridae Non-Structural Proteins

open access: yesViruses, 2017
Flaviviridae-caused diseases are a critical, emerging public health problem worldwide. Flaviviridae infections usually cause severe, acute or chronic diseases, such as liver damage and liver cancer resulting from a hepatitis C virus (HCV) infection and ...
Shun Chen   +3 more
doaj   +2 more sources

Transient receptor potential channels in Flaviviridae infection: A comprehensive review [PDF]

open access: yesChannels
Diseases caused by Flaviviridae viruses exert profound global health and economic burdens due to their high incidence and associated mortality. Infection by the Flaviviridae family often leads to severe acute or chronic illnesses, including hemorrhagic ...
Fuchun Jiang   +2 more
doaj   +2 more sources

Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation

open access: yesViruses, 2022
Members of the Flaviviridae family are posing a significant threat to human health worldwide. Many flaviviruses are capable of inducing severe inflammation in humans.
Anastasia Latanova   +2 more
doaj   +2 more sources

Virus-host coevolution: common patterns of nucleotide motif usage in Flaviviridae and their hosts. [PDF]

open access: yesPLoS ONE, 2009
Virus-host biological interaction is a continuous coevolutionary process involving both host immune system and viral escape mechanisms. Flaviviridae family is composed of fast evolving RNA viruses that infects vertebrate (mammals and birds) and/or ...
Francisco P Lobo   +7 more
doaj   +2 more sources

FLAVi: An Enhanced Annotator for Viral Genomes of Flaviviridae

open access: yesViruses, 2020
Responding to the ongoing and severe public health threat of viruses of the family Flaviviridae, including dengue, hepatitis C, West Nile, yellow fever, and Zika, demands a greater understanding of how these viruses emerge and spread. Updated phylogenies
Adriano de Bernadi Schneider   +3 more
doaj   +2 more sources

Dual-Role Ubiquitination Regulation Shuttling the Entire Life Cycle of the Flaviviridae

open access: yesFrontiers in Microbiology, 2022
Ubiquitination is a reversible protein post-translational modification that regulates various pivotal physiological and pathological processes in all eukaryotes.
Dongjie Cai   +12 more
doaj   +3 more sources

Delayed by Design: Role of Suboptimal Signal Peptidase Processing of Viral Structural Protein Precursors in Flaviviridae Virus Assembly

open access: yesViruses, 2020
The Flaviviridae virus family is classified into four different genera, including flavivirus, hepacivirus, pegivirus, and pestivirus, which cause significant morbidity and mortality in humans and other mammals, including ruminants and pigs.
Nabeel Alzahrani   +3 more
doaj   +3 more sources

Flaviviridae RdRp exploits NSUN2-driven m5C methylation to establish persistent infection. [PDF]

open access: yesPLoS Pathogens
Flaviviridae viruses constitute formidable zoonotic agents with substantial global health and economic ramifications, attributable to their adeptness at circumventing host immune surveillance and establishing persistent infections across human and animal
Jing Chen   +13 more
doaj   +2 more sources

Replicative/transcription enzymes of Flaviviridae.

open access: yesVirologie (Montrouge, France), 2013
The family Flaviviridae comprises several major human pathogens including Hepatitis C virus (genus hepacivirus), yellow fever virus or dengue virus (genus flavivirus). The Flaviviridae genomes are made of a single stranded RNA segment that encodes seven non-structural proteins : NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5 in the flaviviruses like dengue ...
Bressanelli, Stéphane, Lescar, Julien
openaire   +5 more sources

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