Dual-Role Ubiquitination Regulation Shuttling the Entire Life Cycle of the Flaviviridae [PDF]
Frontiers in Microbiology, 2022 Ubiquitination is a reversible protein post-translational modification that regulates various pivotal physiological and pathological processes in all eukaryotes.
Dongjie Cai +12 more
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Modulation of Lipid Droplet Metabolism—A Potential Target for Therapeutic Intervention in Flaviviridae Infections [PDF]
Frontiers in Microbiology, 2017 Lipid droplets (LDs) are endoplasmic reticulum (ER)-related dynamic organelles that store and regulate fatty acids and neutral lipids. They play a central role in cellular energy storage, lipid metabolism and cellular homeostasis.
Yun Lan, Sumana Sanyal
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PLoS Neglected Tropical Diseases, 2022 BackgroundViruses of the family Flaviviridae, including Japanese encephalitis virus (JEV), dengue virus (DENV), yellow fever virus (YFV) and hepatitis C virus (HCV), are widely distributed worldwide.
Ran Wang +6 more
doaj +4 more sources
Innate Immune Evasion Mediated by Flaviviridae Non-Structural Proteins
Viruses, 2017 Flaviviridae-caused diseases are a critical, emerging public health problem worldwide. Flaviviridae infections usually cause severe, acute or chronic diseases, such as liver damage and liver cancer resulting from a hepatitis C virus (HCV) infection and ...
Shun Chen, Mingshu Wang, Anchun Cheng
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Proposed Update to the Taxonomy of Pestiviruses: Eight Additional Species within the Genus Pestivirus, Family Flaviviridae [PDF]
Viruses, 2021 Pestiviruses are plus-stranded RNA viruses belonging to the family Flaviviridae. They comprise several important pathogens like classical swine fever virus and bovine viral diarrhea virus that induce economically important animal diseases.
Alexander Postel +2 more
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Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens [PDF]
Nature, 2016 The Flaviviridae are a family of viruses that cause severe human diseases. For example, dengue virus (DENV) is a rapidly emerging pathogen causing an estimated 100 million symptomatic infections annually worldwide. No approved antivirals are available to
Andreas S Puschnik +2 more
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Virus-Host Coevolution: Common Patterns of Nucleotide Motif Usage in Flaviviridae and Their Hosts [PDF]
PLoS ONE, 2009 Virus-host biological interaction is a continuous coevolutionary process involving both host immune system and viral escape mechanisms. Flaviviridae family is composed of fast evolving RNA viruses that infects vertebrate (mammals and birds) and/or ...
Francisco P Lobo
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Serological evidence of antibodies to Flaviviridae in wild birds in Portugal
Animal DiseasesEmerging infectious diseases are a major threat to biodiversity and an important public health issue. Flaviviruses are the cause of several emerging vector-borne zoonotic arboviruses whose distribution is currently increasing in Europe. The evidence that
Filipa Loureiro +11 more
doaj +2 more sources
Live-Cell Imaging of Flaviviridae Family Virus Infections: Progress and Challenges [PDF]
VirusesThe ability of a virus to be propagated within a host cell is dependent on a multitude of dynamic virus–host interactions. Live-cell imaging is an invaluable approach in the study of virus replication cycles and virus–host interactions as it can allow ...
Siena M. Centofanti, Nicholas S. Eyre
doaj +2 more sources
Interplay between Inflammation and Cellular Stress Triggered by Flaviviridae Viruses
Frontiers in Microbiology, 2016 Flaviviruses, from Flaviviridae virus family, comprises several human pathogens, including Dengue, Zika, Yellow Fever, West Nile and Japanese Encephalitis viruses.
Renato S Aguiar
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