Results 51 to 60 of about 18,525 (157)

Surgical Strikes on Host Defenses: Role of the Viral Protease Activity in Innate Immune Antagonism

Pathogens, 2022
As a frontline defense mechanism against viral infections, the innate immune system is the primary target of viral antagonism. A number of virulence factors encoded by viruses play roles in circumventing host defenses and augmenting viral replication ...
Chue Vin Chin, Mohsan Saeed
doaj   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Protein backbone flexibility pattern is evolutionarily conserved in the Flaviviridae family: A case of NS3 protease in Flavivirus and Hepacivirus

, 2018
Viruses belonging to the Flaviviridae family have been an important health concern for humans, animals and birds alike. No specific treatment is available yet for many of the viral infections caused by the members of this family.
Lennerstrand, Johan,, Palanisamy, Navaneethan,, Akaberi, Dario,, Navaneethan Palanisamy, Johan Lennerstrand, Dario Akaberi   +5 more
core   +2 more sources

Seroprevalence of alphavirus antibodies in a cross-sectional study in southwestern Tanzania suggests endemic circulation of chikungunya. [PDF]

PLoS Neglected Tropical Diseases, 2014
BACKGROUND: To date, Alphavirus infections and their most prominent member, chikungunya fever, a viral disease which first became apparent in Tanzania in 1953, have been very little investigated in regions without epidemic occurrence.
Nina Weller, Petra Clowes, Gerhard Dobler, Elmar Saathoff, Inge Kroidl, Nyanda Elias Ntinginya, Leonard Maboko, Thomas Löscher, Michael Hoelscher, Norbert Heinrich   +9 more
doaj   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Zika virus and microcephaly in Southeast Asia: A cause for concern?

Journal of Infection and Public Health, 2020
Zika virus (ZIKV), a mosquito transmitted virus in the family Flaviviridae, genus Flavivirus, recently emerged to cause infections in more than 70 countries and territories around the world.
Atichat Kuadkitkan, Nitwara Wikan, Wannapa Sornjai, Duncan R. Smith   +3 more
doaj   +1 more source

Membrane‐Permeable Nucleoside T‐1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides

Chemistry – A European Journal, EarlyView.
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier, Duan Li, Leentje Persoons, Graciela Andrei, Robert Snoeck, Dominique Schols, Lieve Naesens, Xiao Jia   +7 more
wiley   +1 more source

Pregnancy and Zika virus

Акушерство, гинекология и репродукция, 2020
Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) in the genus Flavivirus and the Flaviviridae family. In 1947 and 1948 ZIKV was first isolated from a nonhuman primate as well as from mosquitoes in Africa, respectively.
T. V. Startseva, N. N. Kanshina, M. V. Tretyakova, V. O. Bitsadze, J. Kh. Khizroeva, L. S. Radetskaya, N. S. Stuleva, V. I. Tsibizova, A. S. Shkoda, D. V. Blinov, A. D. Makatsariya   +10 more
doaj   +1 more source

Does a decision support tool designed to depict West Nile virus risk explain variation in ruffed grouse Bonasa umbellus use of managed forests?

Wildlife Biology, EarlyView.
Infectious diseases are commonly cited as significant contributors to wildlife population declines. It is, therefore, important to investigate the extent to which tools designed to mitigate the effects of infectious diseases explain wildlife responses to habitat management.
Jacob Goldman, Darin J. McNeil, Lauren M. Chronister, Randall Koleck, Samuel Lapp, Jeffery T. Larkin, Reina Tyl, Justin Kitzes, Jeffery L. Larkin   +8 more
wiley   +1 more source

Maltase 1 regulates DENV2 infection and life history in Aedes aegypti

Insect Science, EarlyView.
Our study employed CRISPR/Cas9 to generate a MAL1 knockout strain of Aedes aegypti, demonstrating that the absence of MAL1 significantly suppresses DENV2 replication in the midgut and impairs viral transmission. The mutation also altered life‐history (hatching/pupation/emerging rates and sex‐specific survival), identifying MAL1 as a novel target for ...
Man‐Jin Li, Jin Cheng, Ya‐Ming Zou, Quan‐Chao Liu, Ding Zhu, Ce‐Jie Lan   +5 more
wiley   +1 more source