Results 41 to 50 of about 827,603 (194)

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

ICTV Virus Taxonomy Profile: Flaviviridae [PDF]

, 2017
The Flaviviridae is a family of small enveloped viruses with RNA genomes of 9000-13 000 bases. Most infect mammals and birds. Many flaviviruses are host-specific and pathogenic, such as hepatitis C virus in the genus Hepacivirus.
Gould, EA, Bukh, J., Alexander Pletnev, Gregor Meyers, ICTV Report Consortium, Bukh, J, Stapleton, JT, Stapleton, J. T., Simmonds, Peter, Jack T. Stapleton, Peter Simmonds, Paul Becher, Muerhoff, S., Simmonds, P, Pletnev, A., Consortium,, Ictv Report, Scott Muerhoff, Gould, E. A., Monath, T, Smith, DB, Donald B. Smith, Meyers, Gregor, Pletnev, A, Ictv Report Consortium,, Rico-Hesse, R, Ernest A. Gould, null null, Tom Monath, Monath, T., Becher, P, Becher, P., Jens Bukh, Meyers, G, Muerhoff, S, Simmonds, P., Rebecca Rico-Hesse, Smith, D. B., Rico-Hesse, R.   +37 more
core   +1 more source

Seroprevalence of alphavirus antibodies in a cross-sectional study in southwestern Tanzania suggests endemic circulation of chikungunya. [PDF]

PLoS Neglected Tropical Diseases, 2014
BACKGROUND: To date, Alphavirus infections and their most prominent member, chikungunya fever, a viral disease which first became apparent in Tanzania in 1953, have been very little investigated in regions without epidemic occurrence.
Nina Weller, Petra Clowes, Gerhard Dobler, Elmar Saathoff, Inge Kroidl, Nyanda Elias Ntinginya, Leonard Maboko, Thomas Löscher, Michael Hoelscher, Norbert Heinrich   +9 more
doaj   +1 more source

Immune Modulatory Therapy for Severe Dengue Hemorrhagic Fever in a Patient With Mitochondrial Complex I Deficiency: A Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Dengue virus (DENV) poses a serious global health challenge, particularly in cases of dengue hemorrhagic fever (DHF). Patients with preexisting mitochondrial disorders may be at increased risk for complications due to the specific impact of DENV on mitochondrial‐dependent cellular processes and immune function.
Audra N. Iness, Ameya S. Walimbe, Emily R. Strouphauer, Michio Hirano, Alejandro D. Iglesias, Valentina Emmanuele, Caitlin C. Griffin, Sheldon L. Kaplan, William A. Gomes, Karen K. Moeller, Stephen F. Kralik, Fernando Scaglia   +11 more
wiley   +1 more source

Current viral infections and epidemics of flaviviridae; lots of grief but also some hope [PDF]

, 2012
Flaviviridae is a family of RNA viruses that includes numerous important human and animal pathogens. Recent studies on subgenomic flaviviridae replicons have revealed that the non-structural (NS) proteins, which are encoded by the C-terminal part of the ...
Champeris Tsaniras, Spyridon, Kossida, Sophia; Biomedical Research Foundation, Academy of Athens, Athens, Greece, Vlachakis, Dimitrios   +2 more
core   +1 more source

Zika virus and microcephaly in Southeast Asia: A cause for concern?

Journal of Infection and Public Health, 2020
Zika virus (ZIKV), a mosquito transmitted virus in the family Flaviviridae, genus Flavivirus, recently emerged to cause infections in more than 70 countries and territories around the world.
Atichat Kuadkitkan, Nitwara Wikan, Wannapa Sornjai, Duncan R. Smith   +3 more
doaj   +1 more source

Membrane‐Permeable Nucleoside T‐1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides

Chemistry – A European Journal, EarlyView.
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier, Duan Li, Leentje Persoons, Graciela Andrei, Robert Snoeck, Dominique Schols, Lieve Naesens, Xiao Jia   +7 more
wiley   +1 more source

Pregnancy and Zika virus

Акушерство, гинекология и репродукция, 2020
Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) in the genus Flavivirus and the Flaviviridae family. In 1947 and 1948 ZIKV was first isolated from a nonhuman primate as well as from mosquitoes in Africa, respectively.
T. V. Startseva, N. N. Kanshina, M. V. Tretyakova, V. O. Bitsadze, J. Kh. Khizroeva, L. S. Radetskaya, N. S. Stuleva, V. I. Tsibizova, A. S. Shkoda, D. V. Blinov, A. D. Makatsariya   +10 more
doaj   +1 more source

Maltase 1 regulates DENV2 infection and life history in Aedes aegypti

Insect Science, EarlyView.
Our study employed CRISPR/Cas9 to generate a MAL1 knockout strain of Aedes aegypti, demonstrating that the absence of MAL1 significantly suppresses DENV2 replication in the midgut and impairs viral transmission. The mutation also altered life‐history (hatching/pupation/emerging rates and sex‐specific survival), identifying MAL1 as a novel target for ...
Man‐Jin Li, Jin Cheng, Ya‐Ming Zou, Quan‐Chao Liu, Ding Zhu, Ce‐Jie Lan   +5 more
wiley   +1 more source

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source