Results 61 to 70 of about 18,525 (157)

Flaviviridae virus nonstructural proteins 5 and 5A mediate viral immune evasion and are promising targets in drug development

, 2018
Infections with viruses in the Flaviviridae family have a vast global and economic impact because of the high morbidity and mortality. The pathogenesis of Flaviviridae infections is very complex and not fully understood because these viruses can inhibit ...
Wei Zhang, Anchun Cheng, Cheng, Anchun, Suresh Mahalingam, Zhang, Wei, Chao Yang, Mahalingam, Suresh, Wang, Mingshu, Chen, Shun, Yang, Chao, Shun Chen, Mingshu Wang   +11 more
core   +1 more source

The Innate Immune Response in DENV- and CHIKV-Infected Placentas and the Consequences for the Fetuses: A Minireview

Viruses, 2023
Dengue virus (DENV) and chikungunya (CHIKV) are arthropod-borne viruses belonging to the Flaviviridae and Togaviridae families, respectively. Infection by both viruses can lead to a mild indistinct fever or even lead to more severe forms of the diseases,
Felipe de Andrade Vieira Alves, Priscila Conrado Guerra Nunes, Laíza Vianna Arruda, Natália Gedeão Salomão, Kíssila Rabelo   +4 more
doaj   +1 more source

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source

Broad-Spectrum Inhibitor of Viruses in the Flaviviridae Family

, 2005
The viruses in the Flaviviridae family have been associated with human and animal diseases. In this report, we demonstrate that compound 2-amino-8-(β-d-ribofuranosyl) imidazo [1,2-a]-s-triazine-4-one (ZX-2401) was capable of inhibiting the production in ...
Ali, S., Craig D. Shimasaki, Joshua O. Ojwang, Shoukath Ali, Robert W. Sidwell, Donald F. Smee, John D. Morrey, Sidwell, R. W., Smee, Donald F., Ojwang, J. O., Morrey, John D., Shimasaki, C. D.   +11 more
core   +1 more source

Inhibition of RNA Helicases of ssRNA⁺ Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae Families [PDF]

, 2011
Many viral pathogens encode the motor proteins named RNA helicases which display various functions in genome replication. General strategies to design specific and selective drugs targeting helicase for the treatment of viral infections could act via one
CORONA, Paola, Irene Briguglio, CARTA, Antonio, BRIGUGLIO, Irene, PIRAS, Sandra, Paola Corona, Sandra Piras, Antonio Carta   +7 more
core   +1 more source

The effects of orally administered lactoferrin in the prevention and management of viral infections: A systematic review [PDF]

, 2022
It has been demonstrated that lactoferrin (LF) plays a role in host defence, but evidence on its potential antiviral property from clinical studies is fragmented.
Santoro, Maria Mercedes, Maria Mercedes Santoro, Baccolini, Valentina, Sinopoli, A, Sinopoli, Alessandra, Isonne, Claudia, Alessandra Sinopoli, Santoro, M, Santoro, MM, Baccolini, V, Claudia Isonne, Valentina Baccolini, Isonne, C   +12 more
core   +1 more source

Scaffold hybridization strategy towards potent hydroxamate-based inhibitors of Flaviviridae viruses and Trypanosoma species. [PDF]

, 2019
Infections with Flaviviridae viruses, such as hepatitis C virus (HCV) and dengue virus (DENV) pose global health threats. Infected individuals are at risk of developing chronic liver failure or haemorrhagic fever respectively, often with a fatal outcome ...
Myrianthopoulos, Vassilios, Pardali, Vasiliki, Vassilaki, Niki, Siozos, Vasileios, Zoidis, Grigoris, Giannakopoulou, Erofili, Mikros, Emmanuel, Kelly, John M, Frakolaki, Efseveia, Taylor, Martin C   +9 more
core   +2 more sources

Molecular detection and genetic characterization of bovine hepacivirus identified in ticks collected from cattle in Harbin, northeastern China

Frontiers in Veterinary Science, 2023
Bovine hepacivirus (BovHepV) is a member of the genus Hepacivirus of the family Flaviviridae, which can cause acute or persistent infections in cattle.
Sheng Yuan, Xin-Yan Yao, Chun-Yang Lian, Sa Kong, Jian-Wei Shao, Xue-Lian Zhang   +5 more
doaj   +1 more source

Mosquito feeding patterns in the context of West Nile and eastern equine encephalitis viruses in eastern Ontario, Canada

Medical and Veterinary Entomology, EarlyView.
Mosquitoes in Eastern Ontario, Canada, readily fed on bloodmeal hosts consistent with patterns observed in other regions of North America. Enzootic and bridge vector mosquitoes fed on amplification hosts like American Robins (Turdus migratorius) together with humans, highlighting a potential route for WNV and EEEV transmission to human populations. Our
Colton R. A. Stephens, Mark R. Forbes, Scott Wilson, Antoinette Ludwig, David R. Lapen, Greg W. Mitchell   +5 more
wiley   +1 more source

Sindbis virus interferes with dengue 4 virus replication and its potential transmission by Aedes albopictus

Parasites & Vectors, 2015
Background Mosquitoes transmit a number of arboviruses associated with disease outbreaks in humans and other animals. The majority of medically important arboviruses belong to three families: Togaviridae, Flaviviridae and Bunyaviridae. Several members of
Ephantus J Muturi, Jeffrey Bara
doaj   +1 more source