Results 21 to 30 of about 30,996 (190)

Cyclophilins and Their Roles in Hepatitis C Virus and Flavivirus Infections: Perspectives for Novel Antiviral Approaches. [PDF]

Pathogens, 2021
Cyclophilins are cellular peptidyl-prolyl isomerases that play an important role in viral infections, with demonstrated roles in the replication of hepatitis C virus (HCV) and other viruses in the Flaviviridae family, such as dengue virus (DENV) and ...
Gallardo-Flores CE, Colpitts CC.
europepmc   +2 more sources

The Role of NS1 Protein in the Diagnosis of Flavivirus Infections. [PDF]

Viruses, 2023
Nonstructural protein 1 (NS1) is a glycoprotein among the flavivirus genus. It is found in both membrane-associated and soluble secreted forms, has an essential role in viral replication, and modulates the host immune response. NS1 is secreted from infected cells within hours after viral infection, and thus immunodetection of NS1 can be used for early ...
Fisher R, Lustig Y, Sklan EH, Schwartz E.   +3 more
europepmc   +4 more sources

Resveratrol as an epigenetic therapy for flavivirus infection: A narrative review

Asian Pacific Journal of Tropical Medicine, 2023
Flaviviruses are a group of positive-stranded RNA viruses that cause a broad spectrum of severe illnesses in humans worldwide. Clinical manifestations of flavivirus infections range from mild febrile illness to hemorrhage, shock, and neurological ...
Kim-Ling Chin, Kim-Kee Tan, Sazaly Abu Bakar, Nurhafiza Zainal   +3 more
doaj   +1 more source

Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses.

PLoS Pathogens, 2023
Sequential dengue virus (DENV) infections often generate neutralizing antibodies against all four DENV serotypes and sometimes, Zika virus. Characterizing cross-flavivirus broadly neutralizing antibody (bnAb) responses can inform countermeasures that ...
Jay Lubow, Lisa M Levoir, Duncan K Ralph, Laura Belmont, Maya Contreras, Catiana H Cartwright-Acar, Caroline Kikawa, Shruthi Kannan, Edgar Davidson, Veronica Duran, David E Rebellon-Sanchez, Ana M Sanz, Fernando Rosso, Benjamin J Doranz, Shirit Einav, Frederick A Matsen Iv, Leslie Goo   +16 more
doaj   +1 more source

Structure and function of capsid protein in flavivirus infection and its applications in the development of vaccines and therapeutics

Veterinary Research, 2021
Flaviviruses are enveloped single positive-stranded RNA viruses. The capsid (C), a structural protein of flavivirus, is dimeric and alpha-helical, with several special structural and functional features.
Xingcui Zhang, Yanting Zhang, Renyong Jia, Mingshu Wang, Zhongqiong Yin, Anchun Cheng   +5 more
doaj   +1 more source

TRIMming Flavivirus Infection [PDF]

Cell Host & Microbe, 2011
Tripartite motif (TRIM) proteins are novel players in antiviral innate immunity. In this issue of Cell Host & Microbe,Taylor et al. (2011) discover the mechanism of action of TRIM79α and show that this interferon-induced protein restricts tick-borne flaviviruses by targeting the viral polymerase for degradation.
openaire   +2 more sources

Neurological disease caused by flavivirus infections [PDF]

, 2018
The Flavivirus genus contains dozens of species with varying geographical distributions. Most flavivirus infections in humans are asymptomatic or manifest as a non-specific febrile illness, sometimes accompanied by rash or arthralgia. Certain species are
Tristan Gibbs, David J Speers
core   +1 more source

Secreted NS1 proteins of tick-borne encephalitis virus and West Nile virus block dendritic cell activation and effector functions

Microbiology Spectrum, 2023
The flavivirus non-structural protein 1 (NS1) is secreted from infected cells into the circulation and the serum levels correlate with disease severity. The effect of secreted NS1 (sNS1) on non-infected mammalian immune cells is largely unknown. Here, we
António A. R. Camarão, Olivia Luise Gern, Felix Stegmann, Felix Mulenge, Bibiana Costa, Babak Saremi, Klaus Jung, Bernd Lepenies, Ulrich Kalinke, Imke Steffen   +9 more
doaj   +1 more source

Mechanism through which retrocyclin targets flavivirus multiplication [PDF]

, 2021
Currently, there are no approved drugs for the treatment of flavivirus infection. Accordingly, we tested the inhibitory effects of the novel θ-defensin retrocyclin-101 (RC-101) against flavivirus infection, and investigated the mechanism underlying the ...
Guo, Jiao, Sun, Lingling, Wang, Wei, Yuan, Weirong, Garzino-Demo, Alfredo, Liu, Yang, Lu, Wuyuan, Jia, Xiaoying, Xiao, Gengfu, Zhou, Minmin   +9 more
core   +1 more source

Proinflammatory Chemokine Levels in Cerebrospinal Fluid of Patients with Neuroinvasive Flavivirus Infections. [PDF]

Microorganisms
Tick-borne encephalitis virus (TBEV) and West Nile virus (WNV) are the most important neuroinvasive arboviruses detected in Europe. In this study, we analyzed cerebrospinal fluid (CSF) concentrations of 12 proinflammatory chemokines (CCL2, CCL3, CCL4 ...
Zidovec-Lepej S, Bodulić K, Bogdanic M, Gorenec L, Savic V, Grgic I, Sabadi D, Santini M, Radmanic Matotek L, Kucinar J, Barbic L, Zmak L, Ferenc T, Stevanovic V, Antolasic L, Milasincic L, Hruskar Z, Vujica Ferenc M, Vilibic-Cavlek T.   +18 more
europepmc   +2 more sources