Results 41 to 50 of about 30,996 (190)

Recent Advances in the Development of Virus-Like Particle-Based Flavivirus Vaccines

Vaccines, 2020
Flaviviruses include several medically important viruses, such as Zika virus (ZIKV), Dengue virus (DENV), West Nile virus (WNV) and Japanese encephalitis virus (JEV).
Naru Zhang, Chaoqun Li, Shibo Jiang, Lanying Du   +3 more
doaj   +1 more source

Flaviviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines

Frontiers in Immunology, 2022
The innate immune system is the host’s first line of defense against the invasion of pathogens including flavivirus. The programmed cell death controlled by genes plays an irreplaceable role in resisting pathogen invasion and preventing pathogen ...
Yuhong Pan, Yuhong Pan, Yuhong Pan, Wenjun Cai, Wenjun Cai, Wenjun Cai, Anchun Cheng, Anchun Cheng, Anchun Cheng, Mingshu Wang, Mingshu Wang, Mingshu Wang, Zhongqiong Yin, Renyong Jia, Renyong Jia, Renyong Jia   +15 more
doaj   +1 more source

A Recombinant Zika Virus Envelope Protein with Mutations in the Conserved Fusion Loop Leads to Reduced Antibody Cross-Reactivity upon Vaccination

Vaccines, 2020
Zika virus (ZIKV) is a zoonotic, human pathogenic, and mosquito-borne flavivirus. Its distribution is rapidly growing worldwide. Several attempts to develop vaccines for ZIKV are currently ongoing.
Beatrice Sarah Berneck, Alexandra Rockstroh, Jasmin Fertey, Thomas Grunwald, Sebastian Ulbert   +4 more
doaj   +1 more source

Anti-flavivirus Properties of Lipid-Lowering Drugs

Frontiers in Physiology, 2021
Although Flaviviruses such as dengue (DENV) and zika (ZIKV) virus are important human pathogens, an effective vaccine or antiviral treatment against them is not available. Hence, the search for new strategies to control flavivirus infections is essential.
Carlos Noe Farfan-Morales, Carlos Daniel Cordero-Rivera, José Manuel Reyes-Ruiz, Arianna M. Hurtado-Monzón, Juan Fidel Osuna-Ramos, Arely M. González-González, Luis Adrián De Jesús-González, Selvin Noé Palacios-Rápalo, Rosa María del Ángel   +8 more
doaj   +1 more source

Bioinformatics in new generation flavivirus vaccines [PDF]

, 2010
Flavivirus infections are the most prevalent arthropod-borne infections world wide, often causing severe disease especially among children, the elderly, and the immunocompromised.
Albert D. M. E. Osterhaus, Martina, B.E.E. (Byron), Osterhaus, A.D.M.E. (Albert), Penelope Koraka, Koraka, P. (Penelope), Byron E. E. Martina, Koraka, Penelopie, Martina, Byron, Osterhaus, Ab   +8 more
core   +1 more source

Protective to a T: The Role of T Cells during Zika Virus Infection

Cells, 2019
CD4 and CD8 T cells are an important part of the host’s capacity to defend itself against viral infections. During flavivirus infections, T cells have been implicated in both protective and pathogenic responses.
Ryan D. Pardy, Martin J. Richer
doaj   +1 more source

Enzyme-linked Immunosorbent assays using novel Japanese encephalitis virus antigen improve the accuracy of clinical diagnosis of flavivirus infections [PDF]

, 2014
The cross-reactive antibodies induced by flavivirus infections confound serodiagnosis and pathogenesis, especially in secondary infections caused by antigenically closely related yet distinct flaviviruses.
Chen, L.K., Crill, W.D., Chiou, S.S., Chang, G.J.J.   +3 more
core   +1 more source

Zika Virus: A New Chapter in the History of Medicine

Acta Médica Portuguesa, 2016
Keywords: Aedes; Arboviruses; Flavivirus; Flaviviridae Infections.
Carlos Brito
doaj   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions [PDF]

, 2018
Autophagy is an evolutionarily conserved cellular process in which intracellular components are eliminated via lysosomal degradation to supply nutrients for organelle biogenesis and metabolic homeostasis.
Po-Yuan Ke
core   +1 more source