Results 61 to 70 of about 30,996 (190)

Prevalence of chronic comorbidities in dengue fever and West Nile virus: A systematic review and meta-analysis.

PLoS ONE, 2018
BackgroundFlavivirus diseases such as dengue fever (DENV), West Nile virus (WNV), Zika and yellow fever represent a substantial global public health concern.
Alaa Badawi, Russanthy Velummailum, Seung Gwan Ryoo, Arrani Senthinathan, Sahar Yaghoubi, Denitsa Vasileva, Emma Ostermeier, Mikayla Plishka, Marcel Soosaipillai, Paul Arora   +9 more
doaj   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Small Molecule Inhibitor of ATPase Activity of HSP70 as a Broad-Spectrum Inhibitor against Flavivirus Infections [PDF]

, 2020
Flaviviruses including Zika virus, Dengue virus, Japanese Encephalitis virus, and Yellow Fever virus cause heavy burdens to public health around the world. No specific antiviral drug is available in the clinic against these flavivirus infections.
Wei Li (7081), Yuexiang Li (1757773), Lei Zhao, Song Li, Wu Zhong, Yongfen Xu (480499), Jingjing Yang (119262), Jin Zhong (9647), Yuexiang Li, Jingjing Yang, Ruiyuan Cao, Yunzheng Yan (8393577), Qingsong Dai, Yunzheng Yan, Wei Li, Jin Zhong, Ruiyuan Cao (4783455), Yongfen Xu, Song Li (65582), Lei Zhao (144153), Qingsong Dai (8393580), Wu Zhong (2535388)   +21 more
core   +1 more source

Detection of anti-premembrane antibody as a specific marker of four flavivirus serocomplexes and its application to serosurveillance in endemic regions

Emerging Microbes and Infections
In the past few decades, several emerging/re-emerging mosquito-borne flaviviruses have resulted in disease outbreaks of public health concern in the tropics and subtropics.
Guan-Hua Chen, Yu-Ching Dai, Szu-Chia Hsieh, Jih-Jin Tsai, Ava Kristy Sy, Mario Jiz, Celia Pedroso, Carlos Brites, Eduardo Martins Netto, Phyllis J. Kanki, Danielle R. D. Saunders, Dana L. Vanlandingham, Stephen Higgs, Yan-Jang S. Huang, Wei-Kung Wang   +14 more
doaj   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Chimeric Vaccines Based on Novel Insect-Specific Flaviviruses

Vaccines, 2021
Vector-borne flaviviruses are responsible for nearly half a billion human infections worldwide each year, resulting in millions of cases of debilitating and severe diseases and approximately 115,000 deaths.
Jessica J. Harrison, Jody Hobson-Peters, Helle Bielefeldt-Ohmann, Roy A. Hall   +3 more
doaj   +1 more source

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

A High-Performance Multiplex Immunoassay for Serodiagnosis of Flavivirus-Associated Neurological Diseases in Horses [PDF]

, 2015
West Nile virus (WNV), Japanese encephalitis virus (JEV), and tick-borne encephalitis virus (TBEV) are flaviviruses responsible for severe neuroinvasive infections in humans and horses.
Yamanaka, Takashi, Lowenski, Steeve, Vanhomwegen, Jessica, Zientara, Stéphan, Durand, Benoit, Desprès, Philippe, Garnier, Annabelle, Blaise-Boisseau, Sandra, Guitton, Edouard, Lecollinet, Sylvie, Nowotny, Norbert, Paulous, Sylvie, Beck, Cécile   +12 more
core   +1 more source

Toll-Like Receptors and RIG-I-Like Receptors Play Important Roles in Resisting Flavivirus

Journal of Immunology Research, 2018
Flaviviridae family is a class of single-stranded RNA virus, which is fatal to human and animals and mainly prevalent in subtropic and tropic countries.
Hong-Yan Guo, Xing-Cui Zhang, Ren-Yong Jia   +2 more
doaj   +1 more source

Zoonotic Flavivirus Exposure in Peri-Urban and Suburban Pig-Keeping in Hanoi, Vietnam, and the Knowledge and Preventive Practices of Pig Farmers

Tropical Medicine and Infectious Disease, 2022
Mosquito-borne diseases (MBDs), including those caused by flaviviruses, remain human health problems for developing and urbanizing economies. This cross-sectional study examined risks of flavivirus exposure through a survey regarding knowledge and ...
Long Pham-Thanh, Thang Nguyen-Tien, Ulf Magnusson, Vuong Nghia Bui, Anh Ngoc Bui, Åke Lundkvist, Duoc Trong Vu, Son Hai Tran, Minh Xuan Can, Hung Nguyen-Viet, Johanna F. Lindahl   +10 more
doaj   +1 more source