Results 71 to 80 of about 3,670,778 (207)

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Detection of anti-premembrane antibody as a specific marker of four flavivirus serocomplexes and its application to serosurveillance in endemic regions

Emerging Microbes and Infections
In the past few decades, several emerging/re-emerging mosquito-borne flaviviruses have resulted in disease outbreaks of public health concern in the tropics and subtropics.
Guan-Hua Chen, Yu-Ching Dai, Szu-Chia Hsieh, Jih-Jin Tsai, Ava Kristy Sy, Mario Jiz, Celia Pedroso, Carlos Brites, Eduardo Martins Netto, Phyllis J. Kanki, Danielle R. D. Saunders, Dana L. Vanlandingham, Stephen Higgs, Yan-Jang S. Huang, Wei-Kung Wang   +14 more
doaj   +1 more source

The Immunopathogenesis of Neurotropic Flavivirus Infection [PDF]

, 2011
The flavivirus genus in the Flaviviridae family comprises over 70 species, most of which are tickor mosquito-borne. They are single-stranded, plus-sense RNA viruses, responsible for significant human and animal morbidity and mortality on all inhabited continents.
King NJC, van Vreden, Terry RL, Getts DR, Yeung AWS, Teague-Getts M, Davison AM, Deffrasnes C., Munoz-Erazo L.   +8 more
openaire   +1 more source

The Role of Host Cholesterol During Flavivirus Infection [PDF]

Frontiers in Cellular and Infection Microbiology, 2018
Ces dernières années, l'émergence et la résurgence des arbovirus ont généré une alerte sanitaire mondiale. Parmi les arbovirus, la dengue (DENV), le virus Zika (ZIKV), le virus de la fièvre jaune (YFV) et le virus du Nil occidental (VNO) appartiennent au genre Flavivirus, provoquent une virémie élevée et parfois une maladie clinique mortelle chez l ...
Juan Fidel Osuna‐Ramos, José Manuel Reyes‐Ruiz, Rosa M. del Ángel   +2 more
openaire   +3 more sources

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Antiviral Effects of an Iminosugar Derivative on Flavivirus Infections [PDF]

Journal of Virology, 2002
ABSTRACT Endoplasmic reticulum (ER) α-glucosidase inhibitors, which block the trimming step of N-linked glycosylation, have been shown to eliminate the production of several ER-budding viruses. Here we investigated the effects of one such inhibitor, N -nonyl-deoxynojirimycin ( N N ...
Wu, S, Lee, C, Liao, C, Dwek, R, Zitzmann, N, Lin, Y   +5 more
openaire   +2 more sources

Chimeric Vaccines Based on Novel Insect-Specific Flaviviruses

Vaccines, 2021
Vector-borne flaviviruses are responsible for nearly half a billion human infections worldwide each year, resulting in millions of cases of debilitating and severe diseases and approximately 115,000 deaths.
Jessica J. Harrison, Jody Hobson-Peters, Helle Bielefeldt-Ohmann, Roy A. Hall   +3 more
doaj   +1 more source

Meta-analysis for the frequency of clinical features in severe flavivirus infections in the selected studies.

, 2018
Meta-analysis for the frequency of clinical features in severe flavivirus infections in the selected studies.
Arrani Senthinathan (5497523), Mikayla Plishka (5497541), Russanthy Velummailum (5497529), Sahar Yaghoubi (5497532), Denitsa Vasileva (5497535), Paul Arora (141025), Marcel Soosaipillai (5497544), Emma Ostermeier (5497538), Alaa Badawi (521535), Seung Gwan Ryoo (5497526)   +9 more
core   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Toll-Like Receptors and RIG-I-Like Receptors Play Important Roles in Resisting Flavivirus

Journal of Immunology Research, 2018
Flaviviridae family is a class of single-stranded RNA virus, which is fatal to human and animals and mainly prevalent in subtropic and tropic countries.
Hong-Yan Guo, Xing-Cui Zhang, Ren-Yong Jia   +2 more
doaj   +1 more source