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Recent Advances in the Development of Virus-Like Particle-Based Flavivirus Vaccines

open access: yesVaccines, 2020
Flaviviruses include several medically important viruses, such as Zika virus (ZIKV), Dengue virus (DENV), West Nile virus (WNV) and Japanese encephalitis virus (JEV).
Naru Zhang   +3 more
doaj   +1 more source

ZIKV Infection and miRNA Network in Pathogenesis and Immune Response

open access: yesViruses, 2021
Over the years, viral infections have caused severe illness in humans. Zika Virus (ZIKV) is a flavivirus transmitted by mosquito vectors that leads to notable neurological impairment, whose most dramatic impact is the Congenital ZIKV Syndrome (CZS). ZIKV
Carolina Manganeli Polonio   +1 more
doaj   +1 more source

Anti-flavivirus Properties of Lipid-Lowering Drugs

open access: yesFrontiers in Physiology, 2021
Although Flaviviruses such as dengue (DENV) and zika (ZIKV) virus are important human pathogens, an effective vaccine or antiviral treatment against them is not available. Hence, the search for new strategies to control flavivirus infections is essential.
Carlos Noe Farfan-Morales   +8 more
doaj   +1 more source

Bioinformatics in new generation flavivirus vaccines [PDF]

open access: yes, 2010
Flavivirus infections are the most prevalent arthropod-borne infections world wide, often causing severe disease especially among children, the elderly, and the immunocompromised.
Albert D. M. E. Osterhaus   +8 more
core   +1 more source

Zika Virus: A New Chapter in the History of Medicine

open access: yesActa Médica Portuguesa, 2016
Keywords: Aedes; Arboviruses; Flavivirus; Flaviviridae Infections.
Carlos Brito
doaj   +1 more source

Protective to a T: The Role of T Cells during Zika Virus Infection

open access: yesCells, 2019
CD4 and CD8 T cells are an important part of the host’s capacity to defend itself against viral infections. During flavivirus infections, T cells have been implicated in both protective and pathogenic responses.
Ryan D. Pardy, Martin J. Richer
doaj   +1 more source

A Recombinant Zika Virus Envelope Protein with Mutations in the Conserved Fusion Loop Leads to Reduced Antibody Cross-Reactivity upon Vaccination

open access: yesVaccines, 2020
Zika virus (ZIKV) is a zoonotic, human pathogenic, and mosquito-borne flavivirus. Its distribution is rapidly growing worldwide. Several attempts to develop vaccines for ZIKV are currently ongoing.
Beatrice Sarah Berneck   +4 more
doaj   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier   +3 more
wiley   +1 more source

Imported Arbovirus Infections in Canada 1974-89

open access: yesCanadian Journal of Infectious Diseases, 1991
From 1974 to 1989, sera from symptomatic patients with histories of recent travel outside Canada were tested for antibodies to several arboviruses, principally of the alphavirus and flavivirus families.
Harvey Artsob, Leslie Spence
doaj   +1 more source

Bagaza Virus in Partridges and Pheasants, Spain, 2010

open access: yesEmerging Infectious Diseases, 2011
In September 2010, an unusually high number of wild birds (partridges and pheasants) died in Cádiz in southwestern Spain. Reverse transcription PCR and virus isolation detected flavivirus infections.
Montserrat Agüero   +8 more
doaj   +1 more source

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