Results 41 to 50 of about 28,583 (169)
Imported Arbovirus Infections in Canada 1974-89
Canadian Journal of Infectious Diseases, 1991 From 1974 to 1989, sera from symptomatic patients with histories of recent travel outside Canada were tested for antibodies to several arboviruses, principally of the alphavirus and flavivirus families.
Harvey Artsob, Leslie Spence
doaj +1 more source
Bagaza Virus in Partridges and Pheasants, Spain, 2010
Emerging Infectious Diseases, 2011 In September 2010, an unusually high number of wild birds (partridges and pheasants) died in Cádiz in southwestern Spain. Reverse transcription PCR and virus isolation detected flavivirus infections.
Montserrat Agüero +8 more
doaj +1 more source
Impact of flavivirus vaccine-induced immunity on primary Zika virus antibody response in humans.
PLoS Neglected Tropical Diseases, 2020 BackgroundZika virus has recently spread to South- and Central America, causing congenital birth defects and neurological complications. Many people at risk are flavivirus pre-immune due to prior infections with other flaviviruses (e.g.
Stefan Malafa +14 more
doaj +1 more source
Advanced Science, EarlyView.We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang +10 more
wiley +1 more source
PLoS ONE, 2019 Two-hundred-nine free ranging non-human primates from 31 locations throughout Costa Rica were captured and released between 1993 and 2012, and blood samples, sera or plasma were collected, to detect antigens and antibodies, and so assess the distribution
Gaby Dolz +5 more
doaj +1 more source
Pathogens, 2023 West Nile virus (WNV) transmission rate is shaped by the interaction between virus reservoirs and vectors, which may be maximized in farm environments.
Laia Casades-Martí +6 more
doaj +1 more source
“More” Artificial mRNAs: Beyond the Art of Nature
Advanced Science, EarlyView.Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Yuanzhe Cui +3 more
wiley +1 more source
Advanced Science, EarlyView.In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu +9 more
wiley +1 more source
PLoS ONE, 2018 BackgroundFlavivirus diseases such as dengue fever (DENV), West Nile virus (WNV), Zika and yellow fever represent a substantial global public health concern.
Alaa Badawi +9 more
doaj +1 more source
ProTides for Antiviral Activity Beyond Liver Cells
Chemistry – A European Journal, EarlyView.A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel +5 more
wiley +1 more source