Results 161 to 170 of about 21,992 (250)

Modulatory Effects of Cirsimarin on Lung Cancer A549 Cells Migration in 2D and 3D Cultures Involves Transcriptional Regulation of Metalloproteinases

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 3, March 2026.
In 2D culture, the cirsimarin (i) decreased cell viability in both assays, (ii) induced apoptosis, (iii) reduced clonogenicity, (iv) prevented cell migration, (v) induced DNA damage, and (vi) negatively modulated gene expression. In the 3D model, reductions in spheroid viability, area, and cell migration were also observed.
Anna Gabriele Prado dos Santos   +10 more
wiley   +1 more source

Kaempferitrin's Dual Assault: Inducing Apoptosis and Ferroptosis in Diffuse Large B‐Cell Lymphoma via NF‐κB Inactivation

open access: yesThe Kaohsiung Journal of Medical Sciences, Volume 42, Issue 3, March 2026.
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is the most common non‐Hodgkin lymphoma and is an aggressive and highly heterogeneous tumor. Kaempferitrin (KPF) is a natural flavonoid glycoside that exerts a protective role in multiple human tumors. However, the impact of KPF on DLBCL remains unclear.
Han‐Shuo Zhang   +3 more
wiley   +1 more source

Cultivar‐Specific and Field Site–Specific Protein and Metabolite Patterns of Faba Bean (Vicia faba L.) Seeds

open access: yesLegume Science, Volume 8, Issue 1, March 2026.
ABSTRACT Sustainable agriculture is an important component of current and future food production, particularly in the face of the rising human world population. In this context, faba bean (Vicia faba L.) is highly valuable due to its capability to enrich soils with nitrogen and because its seeds have a high nutritional value. In this study, we compared
Julia Brandt   +4 more
wiley   +1 more source

Tomato‐Soy Juice Reduces Inflammation and Modulates the Urinary Metabolome in Adults With Obesity

open access: yesMolecular Nutrition &Food Research, Volume 70, Issue 5, 12 March 2026.
Compared to pre‐intervention, consuming a tomato‐soy juice (54 mg lycopene, 189 mg soy isoflavones/d) reduced levels of inflammatory cytokines (IL‐5, IL‐12p70, and GM‐CSF, with TNF‐alpha trending downward), increased plasma lycopene and urinary soy isoflavone metabolites, and altered the urinary metabolome. ABSTRACT Chronic, low‐grade inflammation is a
Maria J. Sholola   +6 more
wiley   +1 more source

Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications

open access: yesMedComm – Oncology, Volume 5, Issue 1, March 2026.
Cellular senescence shapes tumor progression through both antitumor and protumor mechanisms. Senescence triggered by telomere shortening restricts malignant transformation and limits tumor cell proliferation, while the senescence‐associated secretory phenotype (SASP) secretion enhances antitumor immunity by activating cytotoxic T cells.
Huajie Mao   +5 more
wiley   +1 more source

Mycochemical Diversity and Therapeutic Potential of Hymenochaetoid Fungi from Central Asia: Regional and Global Perspectives

open access: yesNew Zealand Journal of Botany, Volume 64, Issue 1, March 2026.
Central Asia harbors a rich yet understudied assemblage of wood‐inhabiting Hymenochaetoid fungi. This review delivers the first comprehensive synthesis of 43 poroid species representing 18 genera documented across montane forests, steppes, and xeric habitats.
Yusufjon Gafforov   +16 more
wiley   +1 more source

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