Results 41 to 50 of about 198,497 (264)

Reversal of Multidrug Resistance in Cancer by Multi-Functional Flavonoids

Frontiers in Oncology, 2019
Multidrug resistance (MDR) resulting from different defensive mechanisms in cancer is one of the major obstacles of clinical treatment. To circumvent MDR many reversal agents have been developed, but most of them fail in clinical trials due to severely ...
Qingmei Ye, Kai Liu, Qun Shen, Qingyue Li, Jinghui Hao, Fangxuan Han, Ren-Wang Jiang   +6 more
doaj   +1 more source

Sustainable Smart Packaging from Protein Nanofibrils

Advanced Materials, EarlyView.
Smart packaging can extend shelf life and improve food quality monitoring. This study introduces a novel smart packaging solution using amyloid fibrils and red radish anthocyanins to monitor seafood spoilage. These findings show that these films effectively indicate shrimp freshness and possess high antibacterial and antioxidant properties, offering a ...
Mohammad Peydayesh, Alan Kovacevic, Leah Hoffmann, Felix Donat, Ciatta Wobill, Laura Baraldi, Jiangtao Zhou, Christoph R. Müller, Raffaele Mezzenga   +8 more
wiley   +1 more source

Paclitaxel/Luteolin Coloaded Dual‐Functional Liposomes for Esophageal Cancer Therapy

Advanced Science, EarlyView.
The authors develop a pH‐sensitive aptamer‐modified liposome (EA2‐PSL‐PTX/LUT) to illustrate a strategy for the precise delivery of combinational chemotherapeutic drugs for esophageal squamous cell carcinoma (ESCC) targeted therapy. EA2‐PSL‐PTX/LUT provides efficient co‐loading, tumor targeting, and controlled release of luteolin and paclitaxel ...
Congyong Sun, Fei Xie, Huiyun Zhang, Lulu Feng, Yuting Wang, Chaofan Huang, Zhizhen Cui, Chao Luo, Li Zhang, Qilong Wang   +9 more
wiley   +1 more source

Metabolic Engineering of Microorganisms for the Production of Flavonoids

Frontiers in Bioengineering and Biotechnology, 2020
Flavonoids are a class of secondary metabolites found in plant and fungus. They have been widely used in food, pharmaceutical, and nutraceutical industries owing to their significant biological activities, such as antiaging, antioxidant, anti ...
Huakang Sheng, Xinxiao Sun, Yajun Yan, Qipeng Yuan, Jia Wang, Xiaolin Shen   +5 more
doaj   +1 more source

Quantum Biochemical Analysis of the TtgR Regulator and Effectors [PDF]

arXiv, 2022
The recent expansion of multidrug-resistant (MDR) pathogens poses significant challenges in treating healthcare-associated infections. Although antibacterial resistance occurs by numerous mechanisms, active efflux of the drugs is a critical concern. A single species of efflux pump can produce a simultaneous resistance to several drugs.
arxiv  

Genome‐Wide Association Studies Reveal the Genetic Architecture of Ionomic Variation in Grains of Tartary Buckwheat

Advanced Science, EarlyView.
In this study, variation and genetic basis of ionome among Tartary buckwheat population are investigated, illuminating their significance in the domestication and diversification of Tartary buckwheat. And three genes (FtACA13 for Na content, FtYPQ1 for Zn content, FtNHX2 for As content) are identified with the dominant haplotypes and functional ...
Zhirong Wang, Yuqi He, Mengyu Zhao, Xiang‐Qian Liu, Hao Lin, Yaliang Shi, Kaixuan Zhang, Guijie Lei, Dili Lai, Tong Liu, Xiaoyang Peng, Jiayue He, Wei Li, Xiangru Wang, Sun‐Hee Woo, Muriel Quinet, Alisdair R. Fernie, Xin‐Yuan Huang, Meiliang Zhou   +18 more
wiley   +1 more source

Tetrandrine alleviates inflammation and neuron apoptosis in experimental traumatic brain injury by regulating the IRE1α/JNK/CHOP signal pathway

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Abstract Aim The aim of this study was to investigate the therapeutic roles of Tetrandrine (TET) on traumatic brain injury (TBI) and the underlying mechanism. Method Traumatic injury model of hippocampal neurons and TBI mouse model were established to evaluate the therapeutic effects.
Huan Liu, Shiqing He, Chong Li, Jianpeng Wang, Qin Zou, Yongshi Liao, Rui Chen   +6 more
wiley   +1 more source

Microbial Glycosylation of Flavonoids [PDF]

Polish Journal of Microbiology, 2016
Flavonoids constitute a large group of polyphenolic compounds naturally found in plants, which have a wide range of biological activity. Although flavonoids are beneficial to human health, their application is limited by their low bioavailability and ...
Sandra Sordon, Jarosław Popłoński, Ewa Huszcza   +2 more
doaj   +1 more source

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
wiley   +1 more source

Antifungal Compounds from the Leaves of Rhynchosia minima

Chemistry &Biodiversity, Volume 19, Issue 12, December 2022., 2022
Abstract Rhynchosia minima, commonly known as jumby bean, is used as a remedy for respiratory ailments in various parts of the world. It is also used by South African traditional healers to treat heart or chest pain. This study aimed to investigate the bioactive constituents of the leaf extracts of R.
Adetola H. Adewole, Ibukun M. Famuyide, Lyndy J. McGaw, Mamoalosi A. Selepe, Natasha October   +4 more
wiley   +1 more source